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公开(公告)号：US20180318737A1
公开(公告)日：2018-11-08
申请号：US15771179
申请日：2016-10-14
发明人： Wilfried MACKEL , Verena GRÖNE
CPC分类号： B01D33/21 , B01D33/68 , B01D63/16 , B01D2313/025 , B01D2313/04 , B01D2313/12 , B01D2313/20 , B01D2313/243 , B01D2315/02 , B01D2319/04
摘要： A filtration arrangement for a filtration device having a container is provided. The filtration arrangement includes at least two hollow shafts rotatably mounted in a machine frame and on which a plurality of membrane filter disks are arranged. The at least one or the plurality of hollow shafts being assigned at least one drive device, the discharge of permeate from the container being possible through the hollow shafts, and it being possible to insert each hollow shaft at one of its ends with the plurality of membrane filter disks into the container, such that its opposite end projects out of the container. A rotatable pump disk, which forms part of a centrifugal pump arrangement for pumping permeate, is arranged or formed at the opposite end of each rotatable hollow shaft.
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2.发明申请公开(公告)号：US20180303997A1
公开(公告)日：2018-10-25
申请号：US16025432
申请日：2018-07-02
申请人： Fenwal, Inc.
发明人： Benjamin E. Kusters , Christopher J. Wegener , Daniel R. Boggs , Kyungyoon Min , William H. Cork , Daryl R. Calhoun , Bryan Blickman , Daniel Lynn
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/265 , A61M1/3403 , A61M1/3496 , A61M1/3633 , A61M1/3687 , A61M1/3692 , A61M1/38 , A61M2205/3331 , A61M2205/50 , A61M2205/60 , B01D61/18 , B01D63/06 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2315/02 , G16H10/40
摘要： A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.
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公开(公告)号：US20180194647A1
公开(公告)日：2018-07-12
申请号：US15912086
申请日：2018-03-05
申请人： PRO-Equipment, Inc.
CPC分类号： C02F1/44 , B01D61/14 , B01D61/18 , B01D61/22 , B01D63/084 , B01D63/16 , B01D65/08 , B01D2313/06 , B01D2313/086 , B01D2313/56 , B01D2315/02 , B01D2315/10 , B01D2319/04 , B01D2321/2016 , B01D2321/2033 , B01D2321/40 , C02F1/66 , C02F2209/005 , C02F2209/02 , C02F2209/06 , C02F2209/40 , C02F2209/42
摘要： A method of operating a high velocity cross flow dynamic membrane filtration includes feeding a fluid stream into a pressure vessel, in which the vessel defines a treatment chamber containing a disc membrane assembly having a first support shaft and a second support shaft, each support shaft defining a longitudinal axis about which is positioned a plurality of axially spaced membrane discs. The method further includes distributing the fluid stream over at least a portion of the disc membrane assembly. The method also includes discharging a first portion of the fluid stream from the vessel and discharging a second portion of the fluid stream from the vessel. The method additionally includes rotating the first support shaft and the second support shaft in a first direction. The rotating includes modulating a rotation rate in response to the flow rate of the second portion of the fluid stream.
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公开(公告)号：US09926212B2
公开(公告)日：2018-03-27
申请号：US14974631
申请日：2015-12-18
申请人： PRO-Equipment, Inc.
CPC分类号： C02F1/44 , B01D61/14 , B01D61/18 , B01D61/22 , B01D63/084 , B01D63/16 , B01D65/08 , B01D2313/06 , B01D2313/086 , B01D2313/56 , B01D2315/02 , B01D2315/10 , B01D2319/04 , B01D2321/2016 , B01D2321/2033 , B01D2321/40 , C02F1/66 , C02F2209/005 , C02F2209/02 , C02F2209/06 , C02F2209/40 , C02F2209/42
摘要： A high velocity cross flow dynamic membrane filtration system includes a disc membrane assembly having a frame and at least two support shafts. Each support shaft defines a longitudinal axis about which is positioned a plurality of axially spaced membrane discs, with each shaft further coupled to the frame. A permeate tube is coupled to each support shaft and in fluid communication with the membrane discs associated with that support shaft. A vessel defines a treatment chamber and is configured to removably support the disc membrane assembly within the treatment chamber. The vessel further includes a wall. The filtration system also includes a drive system. The permeate tubes are configured to extend through a portion of the vessel wall when the disc membrane assembly is positioned within the treatment chamber. The permeate tubes are further configured for rotation by the drive system.
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公开(公告)号：US09895665B2
公开(公告)日：2018-02-20
申请号：US14582108
申请日：2014-12-23
发明人： George G. Jokhadze , Sayantan Mitra
CPC分类号： B01D63/16 , B01D71/56 , B01D2315/02 , B01D2317/02 , C07K1/14 , C07K1/22
摘要： Spin columns that include a poly(acid) membrane separation matrix are provided. Also provided are kits that include the subject devices, as well as methods of using the devices, e.g., in sample preparation (such as protein purification) protocols.
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6.发明申请公开(公告)号：US20180015418A1
公开(公告)日：2018-01-18
申请号：US15456907
申请日：2017-03-13
申请人： Fenwal, Inc.
CPC分类号： B01D61/22 , B01D61/18 , B01D63/16 , B01D2315/02 , B01D2317/00 , G16H10/40 , G16H40/63 , G16H40/67
摘要： A network of cell processing systems including a plurality of cell processing instruments and a server computer. Each cell processing instrument includes a control circuit configured to operate the cell processing instrument according to a modifiable process parameter, a component of the cell processing instrument and a sensor configured to measure a characteristic of the component. The server computer is disposed remotely from the cell processing instruments, and is configured to transmit a request message for a value measured by the sensor, receive a response message based on the request message, and generate a notification message based on the response message.
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7.发明申请公开(公告)号：US20180001266A1
公开(公告)日：2018-01-04
申请号：US15703892
申请日：2017-09-13
申请人： Takara Bio USA, Inc.
发明人： George G. Jokhadze , Sayantan Mitra
CPC分类号： B01D63/16 , B01D71/56 , B01D2315/02 , B01D2317/02 , C07K1/14 , C07K1/22
摘要： Spin columns that include a poly(acid) membrane separation matrix are provided. Also provided are kits that include the subject devices, as well as methods of using the devices, e.g., in sample preparation (such as protein purification) protocols.
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公开(公告)号：US09770545B2
公开(公告)日：2017-09-26
申请号：US15177426
申请日：2016-06-09
申请人： Fenwal, Inc.
CPC分类号： A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
摘要： A method and system for collecting a double volume of red blood cells using a spinning membrane separator is provided by which a first quantity of whole blood is withdrawn from a donor; a first quantity of whole blood is flowed to the spinning membrane separator; where it is separated into a first quantity of red blood cells and a first quantity of plasma. The first quantity of red blood cells and the first quantity of plasma are then flowed to respective collection containers, and at least a portion of the first quantity of plasma is returned to the donor. A second quantity of whole blood withdrawn from the donor, and then separated into a second quantity of red blood cells and a second quantity of plasma using the spinning membrane separator. The second quantity of red blood cells and the second quantity of plasma are then flowed to the respective collection containers, and at least a portion of the second quantity of plasma is returned to the donor.
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公开(公告)号：US09757504B2
公开(公告)日：2017-09-12
申请号：US14594306
申请日：2015-01-12
CPC分类号： A61M1/1623 , A61M1/26 , A61M1/265 , A61M1/3472 , A61M1/3479 , B01D63/16 , B01D65/08 , B01D2315/02 , B01D2321/2033
摘要： Systems and methods for performing hemodialysis to remove metabolic waste from the blood of a patient are disclosed. The systems and methods preferably comprise at least one blood processing apparatus that receives whole blood from a patient. Cellular blood components are removed from the whole blood by hemofiltration, to provide filtered plasma comprising metabolic waste that is substantially reduced of blood cells. The cellular blood components may be returned to the patient. The filtered plasma comprising waste may be removed from the blood processing apparatus through a waste path for further processing in a separate apparatus, or in the same apparatus in a second stage processing procedure to remove metabolic waste components and excess water from the plasma by hemodialysis. At least one of the hemofiltration and hemodialysis processing apparatus comprises a Taylor vortex-enhanced separation apparatus.
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公开(公告)号：US09717838B2
公开(公告)日：2017-08-01
申请号：US15014177
申请日：2016-02-03
申请人： Fenwal, Inc.
CPC分类号： A61M1/3496 , A01N1/0242 , A61M1/0272 , A61M1/265 , A61M1/342 , A61M1/3635 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3672 , A61M2202/0429 , A61M2202/0439 , A61M2205/6072 , A61M2205/7554 , B01D61/18 , B01D63/16 , B01D2313/08 , B01D2313/20 , B01D2313/243 , B01D2315/02 , C12N5/0641
摘要： A method and system for collecting leukoreduced red blood cells employing a spinning membrane separator including a housing having an upper end region and a lower end region in an operating position with a red blood cell outlet in the upper end region of the housing and a whole blood inlet in the lower end region of the housing. The method and system provide for flowing additive solution into the whole blood inlet of the housing to prime the separator; flowing whole blood into the whole blood inlet of the housing; separating red blood cells from the whole blood; flowing separated red blood cells out of the red blood cell outlet of the housing; combining the separated red blood cells with additive solution: passing the separated red blood cells and additive solution combination through a leukoreduction filter; and collecting the filtered red blood cells and additive solution.
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