公开(公告)号：US09839729B2

公开(公告)日：2017-12-12

申请号：US14679636

申请日：2015-04-06

申请人： TERUMO KABUSHIKI KAISHA

发明人： Roland Biset ,  Makoto Hirabuki

IPC分类号： A61B19/00 ,  A61M1/02 ,  A61M1/36 ,  B04B5/04 ,  A61J1/10 ,  B01D21/26 ,  B04B7/16

CPC分类号： A61M1/0218 ,  A61J1/10 ,  A61M1/0227 ,  A61M1/029 ,  A61M1/3693 ,  A61M2205/12 ,  B01D21/262 ,  B04B5/0428 ,  B04B7/16 ,  B04B2005/0435 ,  B04B2005/0478

摘要： A blood bag system includes a BC pooling bag for centrifugation of a buffy coat, a filter for removing white blood cells from a supernatant liquid transferred from the BC pooling bag, a platelet preserving bag for reserving the supernatant liquid that has passed through the filter, a first tube connecting the BC pooling bag and an inlet of the filter, a second tube connecting the platelet preserving bag and an outlet of the filter, and a cassette to be fixed in the centrifugation and separation apparatus. The first tube and the second tube are disposed within the cassette. The cassette includes a first clamp section for closing and opening the first tube, and a second clamp section for closing and opening the second tube.

公开(公告)号：US09566540B2

公开(公告)日：2017-02-14

申请号：US14003833

申请日：2012-03-28

申请人： Luc Felden ,  Sebastien Jouette

发明人： Luc Felden ,  Sebastien Jouette

IPC分类号： B01D21/26 ,  B01D17/02 ,  B01D17/00 ,  B01D61/18 ,  B01D63/16 ,  B04B5/04 ,  B01D71/34

CPC分类号： B01D21/262 ,  B01D17/0217 ,  B01D17/085 ,  B01D61/18 ,  B01D63/16 ,  B01D71/34 ,  B01D2315/02 ,  B04B5/04 ,  B04B5/0407 ,  B04B2005/0435 ,  B04B2005/0478 ,  B04B2005/0485

摘要： The invention provides a filtering and centrifugation device, comprising a barrel, a volume in the barrel for receiving a fluid sample to be processed, a filter medium, at least one piston movable in the barrel to force fluid in the volume through the filter medium to produce a filtrate, and a space for pelleting particulate material. The device is centrifugeable, and said space is located in or communicates with the volume and is located preferably away from the filter medium such that the particulate material does not or at least not completely clog the filter medium during such centrifugation of the device. The invention also provides a method for the sterile filtration of a sample, comprising the steps of introducing the sample into the volume of such a device, subjecting the device to centrifugation to pellet particulate material contained in the sample at the space away from the filter medium, and applying force to the piston(s) to force fluid of the sample in the volume through the filter medium to produce a filtrate. By providing the space for pelleting the particulate material under the influence of the centrifugation force, the clogging of the filter medium can be avoided or considerably delayed. Further, the entire process can be performed in the same device without having to remove the sample for any intermediate clarification steps.

摘要翻译： 本发明提供了一种过滤和离心装置，其包括筒体，桶中用于容纳要处理的流体样品的容积，过滤介质，至少一个可在筒体中移动的活塞，以迫使体积中的流体通过过滤介质至 产生滤液和颗粒物质造粒的空间。 该装置是可离心的，并且所述空间位于该容积中或与该体积连通，并且优选远离过滤介质，使得该颗粒材料在该装置的离心过程中不会或至少不完全堵塞过滤介质。 本发明还提供了一种用于样品的无菌过滤的方法，包括以下步骤：将样品引入这种装置的体积中，使装置进行离心以将包含在样品中的颗粒材料在远离过滤介质的空间 并且向活塞施加力以迫使体积中的样品的流体通过过滤介质以产生滤液。 通过在离心力的影响下提供用于造粒颗粒材料的空间，可以避免或显着延迟过滤介质的堵塞。 此外，整个过程可以在相同的装置中进行，而不必去除样品用于任何中间澄清步骤。

公开(公告)号：US20160016173A1

公开(公告)日：2016-01-21

申请号：US14773276

申请日：2014-03-27

申请人： ANDREAS HETTICH GMBH & CO. KG

发明人： Klaus-Günter EBERLE ,  Timo LIEBERMANN ,  Christoph PABST

IPC分类号： B01L9/00

CPC分类号： B01L9/00 ,  B01L2200/021 ,  B01L2300/0809 ,  B01L2300/123 ,  B04B5/0428 ,  B04B2005/0435

摘要： The invention relates to a support device (14) for supporting a bag (20) containing material to be centrifuged in a centrifuge receptacle (12), said support device (14) comprising a resiliently elastic panel (16) which—when bent—will generate a restoring force, said panel (16) being of a material and a size which will allow it to be bent elastically at least to such an extent that its two ends will contact one another.

摘要翻译： 本发明涉及一种支撑装置（14），用于支撑包含要在离心机容器（12）中离心的材料的袋（20），所述支撑装置（14）包括弹性弹性面板（16），当弯曲时 产生恢复力，所述面板（16）是材料和尺寸，其允许其至少弹性地弯曲到使其两个端部彼此接触的程度。

公开(公告)号：US20150352565A1

公开(公告)日：2015-12-10

申请号：US14731661

申请日：2015-06-05

申请人： Thermo Electron LED GmbH

发明人： Norman Ballhause ,  Mike Armbrecht

IPC分类号： B04B5/04

CPC分类号： B04B5/0414 ,  B04B2005/0435

摘要： Adapter for inserting a sample container in a centrifuge bucket, comprising a bucket-like base body, which delimits a cavity for accommodating said sample container and has a bottom region and an adjoining side wall region, the top edge of which defines an opening edge of said cavity, and an insertion opening, through which said sample container can be inserted in said cavity and which is delimited by said opening edge, at least one separation joint being present in said side wall region of said base body, which separation joint extends from said opening edge in the direction towards said bottom region and which allows for expanding said side wall region from a starting position (P1) to an expanded position (P2) by applying a force in such a way that said opening edge has a larger circumference as compared to the starting position (P1). Said side wall area has two edge regions separated from each other by said separation joint, which at least in the starting position (P1) lie one above the other radially and overlap in the circumferential direction (U), thus forming an overlap region.

摘要翻译： 用于将样品容器插入离心机斗中的适配器，包括桶形基体，其限定用于容纳所述样品容器的空腔，并具有底部区域和相邻的侧壁区域，其顶部边缘限定了 所述腔体和插入开口，所述样品容器可以通过所述插入开口插入所述空腔中并且由所述开口边界限定，所述基体的所述侧壁区域中存在至少一个分离接头，所述分离接头从 所述开口边缘朝向所述底部区域的方向，并且允许通过施加力使所述侧壁区域从起始位置（P1）扩展到扩张位置（P2），使得所述开口边缘具有较大的周长， 与起始位置（P1）相比。 所述侧壁区域具有通过所述分离接头彼此分离的两个边缘区域，所述分隔接头至少在起始位置（P1）沿着另一个在径向上一个在圆周方向（U）上重叠，从而形成重叠区域。

公开(公告)号：US08460267B2

公开(公告)日：2013-06-11

申请号：US13131208

申请日：2009-11-18

申请人： Makoto Hirabuki

发明人： Makoto Hirabuki

IPC分类号： A61B19/00

CPC分类号： B04B5/0428 ,  A61M1/0227 ,  A61M1/0236 ,  A61M1/3693 ,  A61M1/3698 ,  A61M2205/3306 ,  B04B2005/0435 ,  B04B2005/0478

摘要： In a blood bag system mounted in a centrifugation and separation apparatus, a filter is settable in different appropriate orientations at storage time and usage time, and first and second tubes and a filter are arranged respectively in appropriate orientations during use. The blood bag system includes a BC pooling bag for centrifugation of buffy coat, the filter for removing white blood cells from a supernatant liquid transferred from the BC pooling bag, a platelet preserving bag for reserving the supernatant liquid that has passed through the filter, the first tube connecting the BC pooling bag and an inlet of the filter, the second tube connecting the platelet preserving bag and an outlet of the filter, a cassette fixable in the centrifugation and separation apparatus, an attachment for holding the filter, and a hinge section tiltable relative to the cassette with reference to an axis in the circumferential direction.

摘要翻译： 在安装在离心分离装置中的血液袋系统中，过滤器在储存时间和使用时间内可以以不同的适当取向设定，并且第一和第二管和过滤器在使用期间分别以适当的方向排列。 血袋系统包括用于离心沉积蛋白的BC汇集袋，用于从BC汇集袋转移的上清液中除去白细胞的过滤器，用于保留已经通过过滤器的上清液的血小板保存袋， 连接BC池袋和过滤器的入口的第一管，连接血小板保存袋和过滤器出口的第二管，可固定在离心分离装置中的盒，用于保持过滤器的附件，以及铰链部 相对于圆周方向的轴线相对于盒子倾斜。

公开(公告)号：US08336718B2

公开(公告)日：2012-12-25

申请号：US12073878

申请日：2008-03-11

申请人： Noriyuki Shintani ,  Shuji Nosaka ,  Michihiro Yokokawa

发明人： Noriyuki Shintani ,  Shuji Nosaka ,  Michihiro Yokokawa

IPC分类号： B01D21/26

CPC分类号： B04B5/0414 ,  A61M1/3693 ,  A61M2202/10 ,  B01L3/5021 ,  B01L9/06 ,  B01L2200/025 ,  B01L2200/14 ,  B04B2005/0435 ,  Y10T436/25375

摘要： The present invention provides a centrifugal separation-use device capable of maintaining a centrifugal separation-use container in a clean state easily at low cost even when centrifugal separation treatment is carried out using a centrifugal separator in an unclean field. A centrifugal separation-use device 1 for collecting a target component by subjecting a solution containing multiple components to centrifugal separation treatment comprises an inner container 10 having a cylindrical section 12 for accommodating the solution and a plug 14 for hermetically sealing the cylindrical section and configured so as to accommodate the solution in a hermetically sealed state, and an outer container 20 having a support section 22 for removably accommodating the cylindrical section and a delivery section 24 for exposing part of the inner container so that the inner container can be removed, and configured so as to accommodate the inner container in a hermetically sealed state.

摘要翻译： 本发明提供一种离心分离用装置，即使在不干净的场中使用离心分离机进行离心分离处理，也能够以低成本容易地将离心分离用容器维持在清洁状态。 用于通过对含有多个成分的溶液进行离心分离处理来收集目标成分的离心分离用装置1包括：内部容器10，其具有用于容纳溶液的圆筒部12和用于气密密封圆筒部的插塞14， 为了将该溶液容纳在气密密封状态，以及具有用于可拆卸地容纳圆筒部的支撑部22的外部容器20和用于使内部容器的一部分露出从而使内部容器能够被除去的配送部24， 以便容纳内容器处于密封状态。

公开(公告)号：US08066127B2

公开(公告)日：2011-11-29

申请号：US11664212

申请日：2005-08-16

申请人： Philip H. Coelho ,  Eric Sommer ,  Richard Klosinski ,  Jim Hobbs ,  Bruce Baker ,  Brian Malone

发明人： Philip H. Coelho ,  Eric Sommer ,  Richard Klosinski ,  Jim Hobbs ,  Bruce Baker ,  Brian Malone

IPC分类号： B01D24/32 ,  B04B5/02 ,  A61M37/00 ,  B04B5/00

CPC分类号： A61M1/3693 ,  A61M1/0231 ,  A61M1/0272 ,  A61M1/0281 ,  B04B5/0428 ,  B04B2005/0435

摘要： An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. The sensor may be reading one or more of the following characteristics: infrared, optics, density, weight, radioactive, fluorescence, color, magnetism, ultrasonic, capacitance wherein the characteristic is inherent in the blood and blood component or is an additive. Each component may then be separated into its own storage container. The preferred sensors include optics and weight. Besides blood density separation, the device may contain a solution including cells, proteins, subcellular particles or viruses which may be mixed with affinity media or antibodies prior to separation.

摘要翻译： 一种用于收集全血，然后将其分离成组件以供随后使用或储存的装置和方法。 使用独立的袋组来收集样品，然后可以将样品放置在适于装配到离心机中用于分离组分的装置中。 然后根据密度依次提取每个组分，传感器存在于装置中以控制导向各组分收集的阀的操作。 传感器可以读取以下特征中的一个或多个：红外线，光学，密度，重量，放射性，荧光，颜色，磁性，超声波，电容，其特征是血液和血液成分中固有的或者是添加剂。 然后可以将每个组件分离成其自己的存储容器。 优选的传感器包括光学和重量。 除了血液密度分离之外，该装置可以含有可以在分离前可与亲和介质或抗体混合的细胞，蛋白质，亚细胞颗粒或病毒的溶液。

公开(公告)号：US20110077140A1

公开(公告)日：2011-03-31

申请号：US12063190

申请日：2006-08-14

申请人： Brian M. Holmes ,  Johan-Petter Hagström

发明人： Brian M. Holmes ,  Johan-Petter Hagström

IPC分类号： B04B5/02 ,  B01D21/26 ,  B04B13/00

CPC分类号： B04B5/0428 ,  A61M1/3692 ,  A61M1/3693 ,  A61M1/3696 ,  A61M1/3698 ,  B04B2005/0435

摘要： An apparatus for separating a volume of composite liquid into at least a first component and a second component comprising a centrifuge having a rotor with a turntable for supporting a separation bag; a central compartment for containing satellite bags, and fitted with a support member for supporting at least one satellite bag so that a liquid contained in the supported satellite bag drains from the supported satellite bag into the separation bag under centrifugation forces when the rotor is set in rotation.

摘要翻译： 一种用于将体积的复合液体分离成至少第一部件的装置和包括具有转子的离心机的第二部件，所述转子具有用于支撑分离袋的转台; 用于容纳卫星袋的中央隔间，并且配备有用于支撑至少一个卫星袋的支撑构件，使得当所述转子设置在所述支撑卫星袋中时，包含在所支撑的卫星袋中的液体从所述支撑的卫星袋排出到所述分离袋内的离心力 回转。

公开(公告)号：US20110067488A1

公开(公告)日：2011-03-24

申请号：US12879984

申请日：2010-09-10

申请人： Robert A. Levine ,  Stephen C. Wardlaw

发明人： Robert A. Levine ,  Stephen C. Wardlaw

IPC分类号： G01N15/06 ,  B04B5/02

CPC分类号： B04B5/0414 ,  B01L3/50215 ,  B04B2005/0435

摘要： Systems and methods for determining the presence of a target material in a suspension are provided. In one embodiment, a system (100) for isolating a target material in suspension includes at least one tube and float system (106,108), an offset fluid (135) disposed with at least one chamber (101-104), and a centrifuge (109) for centrifugally processing the suspension disposed within the at least one tube and float system the at least one chamber.

摘要翻译： 提供了用于确定悬浮液中目标材料的存在的系统和方法。 在一个实施例中，用于分离悬架中的目标材料的系统（100）包括至少一个管和浮子系统（106,108），设置有至少一个室（101-104）的偏置流体（135）和离心机 109），用于离心处理设置在所述至少一个管内的所述悬浮液并且将所述至少一个室浮起。

公开(公告)号：US20110053201A1

公开(公告)日：2011-03-03

申请号：US12602965

申请日：2008-06-04

申请人： Klaus-Gunter Eberle ,  Roland Biset

发明人： Klaus-Gunter Eberle ,  Roland Biset

IPC分类号： C12Q1/02 ,  C12N5/078 ,  C12M1/00

CPC分类号： A61M1/3693 ,  A61M1/0227 ,  A61M2205/3306 ,  B04B5/0428 ,  B04B2005/0435

摘要： A method for the cell separation from blood or from blood products, having the following steps: (i) inserting a blood bag (35) containing a blood product into a blood bag section (5) of a cartridge (1) (ii) inserting a tube (36) connected to the blood bag (35) into a product transport path (36) which connects the blood bag (35) to a product bag (33) wherein a first sensor (25) and a second sensor (85) are positioned along the product transport path (36), (iii) inserting the cartridge (1) into a rotor of a centrifuge, (iv) spinning the centrifuge for separating the individual blood components, (v) transporting a predetermined quantity of a blood component along the product transport path (36) at a first flow speed, (vi) detecting the composition of the transported blood component by the first sensor (25). The second sensor (85) also detects the composition of the transported blood component after the first sensor (25) has output a signal corresponding to a predetermined composition of the blood component. The transporting and the spinning are terminated when the second sensor (85) detects the predetermined composition and outputs a respective end signal, or when a predetermined period of time has elapsed.

摘要翻译： 一种细胞与血液或血液制品分离的方法，具有以下步骤：（i）将含有血液制品的血袋（35）插入药筒（1）的血袋部分（5）中（ii）插入 将血液袋（35）连接到将血袋（35）连接到产品袋（33）的产品输送路径（36）中的管（36），其中第一传感器（25）和第二传感器（85） 沿着产品输送路径（36）定位，（iii）将盒（1）插入离心机的转子中，（iv）旋转离心机以分离各个血液成分，（v）运送预定量的血液 分量沿着产品输送路径（36）以第一流速进行，（vi）检测由第一传感器（25）输送的血液成分的组成。 第二传感器（85）还检测在第一传感器（25）已经输出与血液成分的预定组成相对应的信号之后输送的血液成分的组成。 当第二传感器（85）检测到预定的组成并输出相应的结束信号时，或者当经过预定的时间段时，传送和旋转终止。