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公开(公告)号：US20070105940A1
公开(公告)日：2007-05-10
申请号：US11549289
申请日：2006-10-13
IPC分类号： A61K31/405
CPC分类号： A61K31/4045
摘要： The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the compound according to formula I wherein n is an integer of from 1 to 10, m is an integer of from 1 to 4 and the total carbon atoms in the alkenyl amide chain is from about 11 to about 20 as an active ingredient together with one or more pharmaceutically-acceptable additives, excipients or diluents.
摘要翻译： 本发明提供了可用于治疗神经性疼痛的方法的药物组合物，所述方法包括施用改善疼痛的有效量的式I化合物，其中n为1至10的整数，m为 1至4，并且链烯基酰胺链中的总碳原子为约11至约20作为活性成分以及一种或多种药学上可接受的添加剂，赋形剂或稀释剂。
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公开(公告)号：US20070259945A1
公开(公告)日：2007-11-08
申请号：US11549334
申请日：2006-10-13
IPC分类号： A61K31/40 , A61P25/02 , C07D209/00
CPC分类号： A61K31/4045
摘要： The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the compound according to formula I wherein X may be Y may be wherein R is H or (CH2)mH, alternatively the bond between X and Y may be a double or triple bond, e.g. X═Y or X≡Y; wherein n is an integer of from 1 to 10, m is an integer of from 1 to 4 and the total carbon atoms in the alkenyl amide chain is from about 11 to about 20 as an active ingredient together with one or more pharmaceutically-acceptable additives, excipients or diluents.
摘要翻译： 本发明提供了用于治疗神经性疼痛的方法的药物组合物，所述方法包括施用改善疼痛的有效量的式I化合物，其中X可以是Y，其中R是H或（CH 2） 或者X和Y之间的键可以是双键或三键，例如 X-Y或X≡Y; 其中n为1至10的整数，m为1至4的整数，链烯基酰胺链中的总碳原子数为约11至约20作为活性成分以及一种或多种药学上可接受的添加剂 ，赋形剂或稀释剂。
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公开(公告)号：US20070129423A1
公开(公告)日：2007-06-07
申请号：US11671785
申请日：2007-02-06
申请人： Vincenzo Di Marzo , Luciano De Petrocellis , Sabatino Malone , Vito De Novellis , David Woodward
发明人： Vincenzo Di Marzo , Luciano De Petrocellis , Sabatino Malone , Vito De Novellis , David Woodward
IPC分类号： A61K31/405
CPC分类号： C07D209/14 , A61K31/405
摘要： The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the compound according to formula I wherein R is an alk(en)yl group, R1 is an alkylen(yl) group, n is 0 or 1 and Ar is a carbocyclic aryl group; wherein X is Y is O, S, or NR wherein R is H or (CH2)mH and m is an integer of from 1 to 5 or the bond between X and Y may be a double or triple bond, e.g. as in X═Y or X≡Y.
摘要翻译： 本发明提供了可用于治疗神经性疼痛的方法的药物组合物，所述方法包括施用改善疼痛的有效量的式I化合物，其中R是烷基（烯）基，R 1是亚烷基 ）基团，n为0或1，Ar为碳环基团; 其中X是Y是O，S或NR，其中R是H或（CH 2 CH 2）m H，m是1至5的整数或者 X和Y可以是双键或三键，例如 如X-Y或X≡Y。
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公开(公告)号：US07902251B2
公开(公告)日：2011-03-08
申请号：US11549262
申请日：2006-10-13
IPC分类号： A01N43/38 , A61K31/40 , C07D209/18
CPC分类号： A61K31/405
摘要： The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the compound according to formula I wherein R is an alk(en)yl group, R1 is an alkylen(yl) group, n is 0 or 1 and Ar is a carbocyclic aryl group.
摘要翻译： 本发明提供了可用于治疗神经性疼痛的方法的药物组合物，所述方法包括施用改善疼痛的有效量的式I化合物，其中R是烷基（烯）基，R 1是亚烷基 ）基团，n为0或1，Ar为碳环芳基。
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公开(公告)号：US20070088073A1
公开(公告)日：2007-04-19
申请号：US11549276
申请日：2006-10-13
IPC分类号： A61K31/405 , C07D209/18
CPC分类号： C07D209/14 , A61K31/405
摘要： The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the compound according to formula I wherein R is an alk(en)yl group, R1 is an alkylen(yl) group, n is 0 or 1 and Ar is a carbocyclic aryl group; wherein X is —CH2—, —CH—, or O, S, or NR wherein R is H or (CH2)mH and m is an integer of from 1 to 5 or the bond between X and Y may be a double or triple bond, e.g. as in X═Y or X≡Y.
摘要翻译： 本发明提供了可用于治疗神经性疼痛的方法的药物组合物，所述方法包括施用改善疼痛的有效量的式I化合物，其中R是烷基（烯）基，R 1是亚烷基 ）基团，n为0或1，Ar为碳环基团; 其中X是-CH 2 - ， - CH-或O，S或NR，其中R是H或（CH 2 CH 2）m - H和m是1至5的整数，或者X和Y之间的键可以是双键或三键，例如 如X-Y或X≡Y。
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公开(公告)号：US20070088072A1
公开(公告)日：2007-04-19
申请号：US11549262
申请日：2006-10-13
IPC分类号： A61K31/405
CPC分类号： A61K31/405
摘要： The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the compound according to formula I wherein R is an alk(en)yl group, R1 is an alkylen(yl) group, n is 0 or 1 and Ar is a carbocyclic aryl group.
摘要翻译： 本发明提供了可用于治疗神经性疼痛的方法的药物组合物，所述方法包括施用改善疼痛的有效量的式I化合物，其中R是烷基（烯）基，R 1是亚烷基 ）基团，n为0或1，Ar为碳环芳基。
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公开(公告)号：US20070129424A1
公开(公告)日：2007-06-07
申请号：US11671806
申请日：2007-02-06
申请人： Vicenzo Di Marzo , Luciano De Petrocellis , Sabatino Malone , Vito De Novellis , David Woodward
发明人： Vicenzo Di Marzo , Luciano De Petrocellis , Sabatino Malone , Vito De Novellis , David Woodward
IPC分类号： A61K31/405
CPC分类号： A61K31/405
摘要： The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the compound according to formula I wherein R is an alk(en)yl group, R1 is an alkylen(yl) group, n is 0 or 1 and Ar is a carbocyclic aryl group.
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8.发明申请PHARMACOLOGICAL PREPARATION FOR TOPICAL USE CONTAINING N-PALMITOYL-VANILLAMIDE 有权含有N-棕榈酰 - 丹宁的局部使用药理学准备公开(公告)号：US20120115808A1
公开(公告)日：2012-05-10
申请号：US13291294
申请日：2011-11-08
申请人： Francesco DELLA VALLE , Luciano De Petrocellis , Sabatino Maione , Vincenzo Di Marzo , Maria Federica Della Valle
发明人： Francesco DELLA VALLE , Luciano De Petrocellis , Sabatino Maione , Vincenzo Di Marzo , Maria Federica Della Valle
IPC分类号： A61K31/165 , A61K31/728 , A61P29/00 , A61K31/201
CPC分类号： A61K31/165 , A61K9/0014 , A61K9/0031 , A61K9/0034 , A61K9/0048 , A61K9/006 , A61K9/0095 , A61K9/06 , A61K9/7038 , A61K31/07 , A61K31/194 , A61K31/728 , A61K45/06 , A61K2300/00
摘要： The present invention relates to topical preparations containing N-palmitoyl-vanillamide having hyperalgesic activity. In particular, the invention relates to N-palmitoyl-vanillamide for use in the treatment of pathologies selected from: post-herpetic neuralgia, neuralgia of trigeminus, occipital neuralgia, dental neuralgia, glottopharyngeal neuralgia, uremic neuralgia, diabetic neuralgia, headache of different origin, neuropathic itch, neurogenic itch, uremic itch, vulvodinia, vulvar vestibulitis, ano-rectal pain and itch, balano-preputial pain and itch, painful urogenital disorders of dogs and cats, psoriasis-associated pruritus and pain, itching skin diseases (e.g. atopic dermatitis) in the human and veterinary field, muscular pain, pain of the tendon, osteoarthritis associated pain in humans, dogs and cats; painful eye diseases in the human and veterinary field, inflammatory pathologies of the oral cavity in the human and veterinary field.
摘要翻译： 本发明涉及具有过敏反应活性的N-棕榈酰 - 香草酰胺的局部制剂。 特别地，本发明涉及用于治疗选自以下的病理学的N-棕榈酰基 - 香草酰胺：疱疹后神经痛，三叉神经痛神经痛，枕骨神经痛，牙齿神经痛，咽喉神经痛，尿毒症神经痛，糖尿病性神经痛，不同来源的头痛 ，神经性瘙痒，神经源性瘙痒，尿毒症瘙痒，外阴阴道炎，外阴前庭炎，直肠疼痛和瘙痒，巴拉阴性疼痛和瘙痒，狗和猫的疼痛性泌尿生殖器疾病，牛皮癣相关性瘙痒和疼痛，瘙痒性皮肤病 人类和兽医领域的肌肉炎，肌肉疼痛，肌腱疼痛，人类，狗和猫中的骨关节炎相关疼痛; 人类和兽医领域的痛苦的眼睛疾病，人类和兽医领域的口腔炎症病理。
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公开(公告)号：US20100249223A1
公开(公告)日：2010-09-30
申请号：US12596500
申请日：2008-04-17
IPC分类号： A61K31/352 , A61K31/05 , A61P25/00 , A61P29/00
CPC分类号： A61K36/185 , A61P35/00
摘要： The present invention relates to the use of cannabinoid-containing plant extracts in the prevention or treatment of diseases or conditions that are alleviated by blockade of one or more types of TRP channel. Preferably the subset of TRP channel that is blockaded is the TRPA channel. More preferably the TRPA channel is the TRPA1 channel. Preferably the diseases or conditions to be prevented or treated include: neuropathic pain, inflammation or vasoconstriction. Alternatively the TRP channel that is blockaded is the TRPM channel. More preferably the TRPM channel is the TRPM8 channel. Preferably the diseases or conditions to be prevented or treated are cancer. More preferably the cancers to be treated include: cancer of the prostate, cancer of the breast, cancer of the colon, cancer of the lung or cancer of the skin. Alternatively the TRP channel that is blockaded is the TRPV channel. More preferably the TRPV channel is the TRPV1 channel. Preferably the diseases or conditions to be prevented or treated include neuropathic pain, inflammation or vasoconstriction.
摘要翻译： 本发明涉及含有大麻素的植物提取物在预防或治疗通过封锁一种或多种TRP通道而减轻的疾病或病症中的用途。 优选地，阻塞的TRP信道的子集是TRPA信道。 更优选地，TRPA信道是TRPA1信道。 优选地，要预防或治疗的疾病或病症包括：神经性疼痛，炎症或血管收缩。 或者，阻塞的TRP信道是TRPM信道。 更优选地，TRPM信道是TRPM8信道。 优选地，预防或治疗的疾病或病症是癌症。 更优选地，待治疗的癌症包括：前列腺癌，乳腺癌，结肠癌，肺癌或皮肤癌。 或者，阻塞的TRP信道是TRPV信道。 更优选地，TRPV信道是TRPV1信道。 优选地，要预防或治疗的疾病或病症包括神经性疼痛，炎症或血管收缩。
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10.发明授权N-acylvanillinamide derivatives capable of activating peripheral cannabinoid receptors 有权能够激活外周大麻素受体的N-酰基万古林酰胺衍生物公开(公告)号：US07244767B2
公开(公告)日：2007-07-17
申请号：US10949322
申请日：2004-09-27
申请人： Tiziana Bisogno , Francesco Della Valle , Luciano De Petrocellis , Vincenzo Di Marzo , Gabriele Marcolongo , Dominique Melck
发明人： Tiziana Bisogno , Francesco Della Valle , Luciano De Petrocellis , Vincenzo Di Marzo , Gabriele Marcolongo , Dominique Melck
IPC分类号： A61K31/165 , A61K31/16
CPC分类号： A61K31/00
摘要： The present invention relates to the use of N-acylvanillinamide derivatives capable of activating the peripheral receptor CB1 of cannabinoids. In particular, the present invention relates to the use of compounds of general formula (I) in which the meanings of R, R1, R3 and Y are as defined in the description, for the preparation of a medicinal product which is capable of activating the peripheral receptor CB1 of cannabinoids.
摘要翻译： 本发明涉及能够激活大麻素的外周受体CB1的N-酰基万古霉素酰胺衍生物的用途。 特别地，本发明涉及通式（I）化合物的用途，其中R 1，R 1，R 3和Y的含义如 描述了用于制备能够激活大麻素的外周受体CB1的药用产品。
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