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34 条记录 (耗时 0.017 秒)

    Method of Enhancing Hair Growth
    1.
    发明申请
    Method of Enhancing Hair Growth 有权
    增加头发生长的方法

    公开(公告)号：US20080070988A1

    公开(公告)日：2008-03-20

    申请号：US11943714

    申请日：2007-11-21

    申请人： David Woodward ,  Amanda VanDenburgh

    发明人： David Woodward ,  Amanda VanDenburgh

    IPC分类号： A61K31/165 ,  A61Q7/00

    CPC分类号： A61K8/42 ,  A61K8/042 ,  A61K8/06 ,  A61K31/165 ,  A61K31/557 ,  A61K31/558 ,  A61K2800/10 ,  A61Q7/00 ,  A61Q7/02

    摘要： Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I wherein the dashed bonds represent a single or double bond which can be in the cis or trans configuration, A, B, Z, X, R1 and R2 are as defined in the specification. Such compositions are used in treating the skin or scalp of a human or non-human animal. Bimatoprost is preferred for this treatment.

    摘要翻译： 公开了用于刺激毛发生长的方法和组合物，其中所述组合物包括环戊烷庚酸，由式I表示的2-环烷基或芳基烷基化合物，其中虚线键代表单键或双键，其可以是顺式或反式构型 A，B，Z，X，R 1和R 2均如说明书中所定义。 这样的组合物用于治疗人或非人动物的皮肤或头皮。 比马前列素优选用于治疗。

    METHOD FOR TREATING PAIN
    3.
    发明申请
    METHOD FOR TREATING PAIN 审中-公开
    治疗疼痛的方法

    公开(公告)号：US20070129423A1

    公开(公告)日：2007-06-07

    申请号：US11671785

    申请日：2007-02-06

    申请人： Vincenzo Di Marzo ,  Luciano De Petrocellis ,  Sabatino Malone ,  Vito De Novellis ,  David Woodward

    发明人： Vincenzo Di Marzo ,  Luciano De Petrocellis ,  Sabatino Malone ,  Vito De Novellis ,  David Woodward

    IPC分类号： A61K31/405

    CPC分类号： C07D209/14 ,  A61K31/405

    摘要： The present invention provides pharmaceutical compositions useful in a method for treating neuropathic pain, said method comprising administration of a pain-ameliorating effective amount of the compound according to formula I wherein R is an alk(en)yl group, R1 is an alkylen(yl) group, n is 0 or 1 and Ar is a carbocyclic aryl group; wherein X is Y is O, S, or NR wherein R is H or (CH2)mH and m is an integer of from 1 to 5 or the bond between X and Y may be a double or triple bond, e.g. as in X═Y or X≡Y.

    摘要翻译： 本发明提供了可用于治疗神经性疼痛的方法的药物组合物，所述方法包括施用改善疼痛的有效量的式I化合物，其中R是烷基（烯）基，R 1是亚烷基 ）基团，n为0或1，Ar为碳环基团; 其中X是Y是O，S或NR，其中R是H或（CH 2 CH 2）m H，m是1至5的整数或者 X和Y可以是双键或三键，例如 如X-Y或X≡Y。

    Abnormal cannabidiols as agents for lowering intraocular pressure
    4.
    发明申请
    Abnormal cannabidiols as agents for lowering intraocular pressure 审中-公开
    异常大麻素作为降低眼内压的药物

    公开(公告)号：US20050282913A1

    公开(公告)日：2005-12-22

    申请号：US10874441

    申请日：2004-06-22

    申请人： June Chen ,  David Woodward

    发明人： June Chen ,  David Woodward

    IPC分类号： A61K31/045

    CPC分类号： A61K31/045

    摘要： The invention relates to the use of Abnormal Cannabidiols as potent ocular hypotensives, and are particularly suitable for the management of glaucoma. In particular said compounds are represented by formula I or formula or formula III

    摘要翻译： 本发明涉及使用异大麻脂作为有效的眼睛低血压剂，特别适用于治疗青光眼。 特别地，所述化合物由式I或式或式III表示

    Abnormal cannabidiols as neuroprotective agents for the eye
    5.
    发明申请
    Abnormal cannabidiols as neuroprotective agents for the eye 审中-公开
    异常大麻素作为眼睛的神经保护剂

    公开(公告)号：US20050282912A1

    公开(公告)日：2005-12-22

    申请号：US10874440

    申请日：2004-06-22

    申请人： June Chen ,  David Woodward

    发明人： June Chen ,  David Woodward

    IPC分类号： A61K31/05

    CPC分类号： A61K31/05

    摘要： The invention relates to the use of Abnormal Cannabidiols as neuroprotective agents. In particular said compounds are represented by the formula I wherein R is selected from the group consisting of (CH2)x wherein x is 0 or an integer of from 1 to 7.

    摘要翻译： 本发明涉及使用异大麻脂作为神经保护剂。 特别地，所述化合物由式I表示，其中R选自（CH 2）x X其中x为0或1至7的整数 。

    Abnormal cannabidiols as agents for lowering intraocular pressure
    6.
    发明申请
    Abnormal cannabidiols as agents for lowering intraocular pressure 审中-公开
    异常大麻素作为降低眼内压的药物

    公开(公告)号：US20050282902A1

    公开(公告)日：2005-12-22

    申请号：US11073209

    申请日：2005-03-05

    申请人： June Chen ,  David Woodward

    发明人： June Chen ,  David Woodward

    IPC分类号： A61K31/05 ,  A61K31/138 ,  A61K31/557 ,  A61K45/06

    CPC分类号： A61K31/05 ,  A61K31/138 ,  A61K31/557 ,  A61K45/06 ,  A61K2300/00

    摘要： The invention relates to the use of Abnormal Cannabidiols in a combination with a drug selected from the group consisting of β-blockers, adrenergic agonists, carbonic anhydrase inhibitors, cholinergic agonists, chlolinesterase inhibitors, glutamate antagonists, prostamides and prostaglandins and the like, or pharmaceutically acceptable salts or prodrugs thereof as potent ocular hypotensives. Said combinations are particularly suitable for the management of glaucoma. In particular said Abnoral Cannibidiols are represented by formula I or formula II or formula III

    摘要翻译： 本发明涉及与选自β-受体阻滞剂，肾上腺素能激动剂，碳酸酐酶抑制剂，胆碱能激动剂，胆碱酯酶抑制剂，谷氨酸拮抗剂，前列腺酰胺和前列腺素等的药物组合使用的异大麻脂类，或药学上 其可接受的盐或前药作为有效的眼睛低血压。 所述组合特别适用于治疗青光眼。 特别地，所述腹部大戟素由式I或式II或式III表示

    Human COX-1 alternatively spliced variants and methods of using same
    7.
    发明申请
    Human COX-1 alternatively spliced variants and methods of using same 有权
    人类COX-1可变剪接变体及其使用方法

    公开(公告)号：US20050233429A1

    公开(公告)日：2005-10-20

    申请号：US10663377

    申请日：2003-09-15

    申请人： Yanbin Liang ,  David Woodward

    发明人： Yanbin Liang ,  David Woodward

    IPC分类号： C07H21/04 ,  C07K16/40 ,  C12N20060101 ,  C12N9/02

    CPC分类号： C12N9/0083

    摘要： The invention provides an isolated polypeptide containing the amino acid sequence of SEQ ID NO: 14, 16, 18, 20, 22 or 24. The invention also provides an isolated polypeptide containing a) an amino acid sequence having at least 50% amino acid identity with SEQ ID NO: 10, and b) an amino acid sequence selected from SEQ ID NOS: 14, 16, 18, 20, 22, or 24; or a conservative variant thereof. The invention further provides an isolated polypeptide containing the amino acid sequence of SEQ ID NO: 2, 4, 6, or 8. The invention also provides a method for identifying a compound that modulates a COX-1 variant by contacting an isolated COX-1 variant or a COX-1 variant over-expressed in a genetically engineered cell with a compound and determining the level of an indicator which correlates with modulation of a COX-1 variant, where an alteration in the level of the indicator as compared to a control level indicates that the compound is a compound that modulates the COX-1 variant.

    摘要翻译： 本发明提供了含有SEQ ID NO：14,16,18,20,22或24的氨基酸序列的分离的多肽。本发明还提供了分离的多肽，其含有a）具有至少50％氨基酸同一性的氨基酸序列 具有SEQ ID NO：10，和b）选自SEQ ID NO：14,16,18,20,22或24的氨基酸序列; 或其保守变体。 本发明还提供了含有SEQ ID NO：2,4,6或8的氨基酸序列的分离的多肽。本发明还提供了通过使分离的COX-1接触来鉴定调节COX-1变体的化合物的方法 变体或在具有化合物的遗传工程细胞中过表达的COX-1变体，并确定与COX-1变体的调节相关的指标水平，其中与对照相比，指标水平的改变 水平表示该化合物是调节COX-1变体的化合物。

    3-DIMENSIONAL DIPOLAR MODULAR ASSESSMENT OF PERCEIVED CHANGE
    9.
    发明申请
    3-DIMENSIONAL DIPOLAR MODULAR ASSESSMENT OF PERCEIVED CHANGE 审中-公开

    公开(公告)号：US20190272079A1

    公开(公告)日：2019-09-05

    申请号：US15910967

    申请日：2018-03-02

    申请人： Justin David Woodward

    发明人： Justin David Woodward

    IPC分类号： G06F3/0481 ,  G06T19/00

    摘要： Methods and systems for assessing perceptual characteristics are provided. In one embodiment, a process is applied which includes receiving at a processing device a first individualized perceptual domain, a second individualized perceptual domain, and a third individualized perceptual domain; receiving a first perceptual characteristic range of a behavior from the first individualized perceptual domain; receiving a second perceptual characteristic range of the behavior from the second individualized perceptual domain; receiving a third perceptual characteristic range of the behavior range from the third individualized perceptual domain; creating a current perceptual range from the first perceptual characteristic range of the behavior, the second perceptual characteristic range of the behavior, and the third perceptual characteristic range of the behavior; converting the current perceptual range into a 3-dimensional representation of the current perceptual range within the first individualized perceptual domain, the second individualized perceptual domain, and the third individualized perceptual domain; and presenting the 3-dimensional representation of the current perceptual range.