公开(公告)号：US06788394B1

公开(公告)日：2004-09-07

申请号：US10249637

申请日：2003-04-28

申请人： Luis Humberto Garcia-Rubio ,  Yvette D. Mattley ,  German Leparc ,  Manuel Bayona ,  Andres Cardenas

发明人： Luis Humberto Garcia-Rubio ,  Yvette D. Mattley ,  German Leparc ,  Manuel Bayona ,  Andres Cardenas

IPC分类号： G01N3348

CPC分类号： G01N33/80 ,  G01N15/0205 ,  G01N21/31 ,  G01N21/49 ,  G01N33/72 ,  G01N33/721 ,  Y02A50/53 ,  Y02A50/58

摘要： An infectious disease or disorder in a fluid, such as a mammalian blood sample, is detected by taking a transmission spectrum of a test sample in at least a portion of the ultraviolet visible near-infrared and comparing the spectrum with a standard sample spectrum. From the comparison it is then determined whether the fluid from the test sample contains an infectious disease or disorder, and an identity of the infectious disease or disorder is determined. Spectroscopic and multiwavelength turbidimetry techniques provide a rapid, inexpensive, and convenient means for diagnosis. The comparison and determination steps may be performed visually or by spectral deconvolution.

摘要翻译： 通过在紫外可见近红外的至少一部分中取测定样品的透射光谱，并将该光谱与标准样品光谱进行比较，来检测流体（例如哺乳动物血液样品）中的感染性疾病或病症。 从比较中，确定来自测试样品的流体是否含有感染性疾病或病症，并确定感染性疾病或病症的身份。 光谱和多波长比浊法技术为诊断提供了快速，便宜和方便的手段。 比较和确定步骤可以通过视觉或通过光谱去卷积来执行。

公开(公告)号：US5589932A

公开(公告)日：1996-12-31

申请号：US385717

申请日：1995-02-08

申请人： Luis H. Garcia-Rubio ,  Manuel Bayona ,  Robert Potter ,  German Leparc

发明人： Luis H. Garcia-Rubio ,  Manuel Bayona ,  Robert Potter ,  German Leparc

IPC分类号： G01N21/31 ,  G01N21/49 ,  G01N33/80 ,  G01N33/48 ,  A61B5/00 ,  G06F15/00

CPC分类号： G01N33/80 ,  G01N21/31 ,  G01N21/49

摘要： A method and apparatus for determining the type of a blood sample are provided wherein a turbidity spectrum of the blood sample is collected over a predetermined wavelength range, from which is calculated an extinction spectrum. This extinction spectrum is then compared with a set of control spectra collected from control blood samples having known blood types, from which the type of the blood sample can be determined. A further method is provided for for detecting the presence of a substance in a bodily fluid sample, the substance having a size in the range of generally 0.5 to 20 .mu.m. Exemplary substances that could be of interest to detect include, but are not limited to, hemoglobin, bilirubin, red blood cell antigens, microorganisms, and viruses. This embodiment includes the additional step of deconvoluting the extinction spectrum to obtain a particle size distribution for comparison with a database of control samples.

摘要翻译： 提供了一种用于确定血液样本类型的方法和装置，其中在预定波长范围内收集血液样本的浊度谱，由此计算消光谱。 然后将该消光谱与从具有已知血型的对照血液样品收集的一组对照光谱进行比较，从该血液样品中可以确定血液样品的类型。 提供了一种用于检测物质在体液样品中的存在的另一种方法，该物质的大小通常在0.5至20μm的范围内。 可能感兴趣的检测的示例性物质包括但不限于血红蛋白，胆红素，红细胞抗原，微生物和病毒。 该实施方案包括解卷积消光谱以获得粒度分布的附加步骤，用于与对照样品的数据库进行比较。

公开(公告)号：US08163473B2

公开(公告)日：2012-04-24

申请号：US12453250

申请日：2009-05-05

申请人： Jaime Matta ,  Manuel Bayona

发明人： Jaime Matta ,  Manuel Bayona

IPC分类号： C12Q1/00

CPC分类号： C12Q1/6897 ,  C12Q1/6886

摘要： The present invention presents a method for using DNA repair capacity (DRC) as a blood biomarker to calculate the risk of a female subject developing breast cancer obtained from a blood sample by using a luciferase reporter gene method that permits calculating a percent DRC for the subject. A subject with a percent DRC below 3.1% is considered as being at risk for breast cancer and a subject with a percent DRC above 3.1% as being at low risk for breast cancer. This method comprises a further estimation of an adjusted risk of the subject to develop breast cancer using a logistic regression equation in which the DRC value is included as one of the variables.

摘要翻译： 本发明提供了使用DNA修复能力（DRC）作为血液生物标志物的方法，通过使用荧光素酶报告基因方法计算从血液样品获得的发展中的乳腺癌的风险，所述方法允许计算受试者的DRC百分数 。 DRC低于3.1％的受试者被认为存在乳腺癌风险，DRC高于3.1％的受试者患乳腺癌的风险较低。 该方法包括使用其中包含DRC值作为变量之一的逻辑回归方程进一步估计受试者发展乳腺癌的风险。