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    Spectrophotometric method and apparatus for the characterization of blood and blood types
    1.
    发明授权
    Spectrophotometric method and apparatus for the characterization of blood and blood types 失效
    用于表征血液和血液类型的分光光度法和仪器

    公开(公告)号：US5589932A

    公开(公告)日：1996-12-31

    申请号：US385717

    申请日：1995-02-08

    申请人： Luis H. Garcia-Rubio ,  Manuel Bayona ,  Robert Potter ,  German Leparc

    发明人： Luis H. Garcia-Rubio ,  Manuel Bayona ,  Robert Potter ,  German Leparc

    IPC分类号： G01N21/31 ,  G01N21/49 ,  G01N33/80 ,  G01N33/48 ,  A61B5/00 ,  G06F15/00

    CPC分类号： G01N33/80 ,  G01N21/31 ,  G01N21/49

    摘要： A method and apparatus for determining the type of a blood sample are provided wherein a turbidity spectrum of the blood sample is collected over a predetermined wavelength range, from which is calculated an extinction spectrum. This extinction spectrum is then compared with a set of control spectra collected from control blood samples having known blood types, from which the type of the blood sample can be determined. A further method is provided for for detecting the presence of a substance in a bodily fluid sample, the substance having a size in the range of generally 0.5 to 20 .mu.m. Exemplary substances that could be of interest to detect include, but are not limited to, hemoglobin, bilirubin, red blood cell antigens, microorganisms, and viruses. This embodiment includes the additional step of deconvoluting the extinction spectrum to obtain a particle size distribution for comparison with a database of control samples.

    摘要翻译： 提供了一种用于确定血液样本类型的方法和装置，其中在预定波长范围内收集血液样本的浊度谱，由此计算消光谱。 然后将该消光谱与从具有已知血型的对照血液样品收集的一组对照光谱进行比较，从该血液样品中可以确定血液样品的类型。 提供了一种用于检测物质在体液样品中的存在的另一种方法，该物质的大小通常在0.5至20μm的范围内。 可能感兴趣的检测的示例性物质包括但不限于血红蛋白，胆红素，红细胞抗原，微生物和病毒。 该实施方案包括解卷积消光谱以获得粒度分布的附加步骤，用于与对照样品的数据库进行比较。

    Spectrophotometric method and apparatus for blood typing
    3.
    发明授权
    Spectrophotometric method and apparatus for blood typing 有权
    分光光度法和血液分型装置

    公开(公告)号：US06330058B1

    公开(公告)日：2001-12-11

    申请号：US09548569

    申请日：2000-04-13

    申请人： Luis Humberto Garcia-Rubio ,  Smita Narayanan ,  German Leparc ,  Robert Potter ,  Sharyn Orton

    发明人： Luis Humberto Garcia-Rubio ,  Smita Narayanan ,  German Leparc ,  Robert Potter ,  Sharyn Orton

    IPC分类号： G01N3348

    CPC分类号： G01N33/80 ,  G01N21/31

    摘要： A method and apparatus for characterizing the type of a blood sample are provided wherein an optical density spectrum of the sample is collected over a predetermined wavelength range. A reference optical density spectrum is collected over a predetermined wavelength range for a portion of the blood sample diluted in saline. Another portion of the blood sample is then mixed with an antibody corresponding to a known blood type (e.g., anti-A, anti-B, anti-D antibody). The optical density spectrum is then collected over a predetermined wavelength range for blood diluted with saline and each antibody in saline. The slopes are then calculated over a predetermined wavelength range for each spectrum. A numerical indicator of agglutination is then calculated by dividing the slope of each antibody-treated sample by the slope of the sample in saline. The resulting number is multiplied by 100. The agglutination index (AI) is arrived at by subtracting this number from 100 so that the magnitude of the AI is a reflection of the degree of agglutination of the sample. A high index value indicates large agglutination (i.e., strong interaction with antibody). Blood type is determined by comparing the AI to a predetermined empirical cutoff value. Typically cutoff values greater than 17 indicate type-specific interaction (type AB samples yield AI values over 17 with both anti-A and anti-B antibodies, while type O samples yield AI values less than 17 with both anti-A and anti-B antibodies).

    摘要翻译： 提供了用于表征血液样本的类型的方法和装置，其中在预定波长范围内收集样品的光密度谱。 对于在盐水中稀释的部分血液样品，在预定波长范围内收集参考光密度光谱。 然后将另一部分血液样品与对应于已知血型（例如抗A，抗B，抗-D抗体）的抗体混合。 然后在预定波长范围内收集用盐水稀释的血液和盐水中的每种抗体的光密度谱。 然后在每个频谱的预定波长范围内计算斜率。 然后通过将每个抗体处理的样品的斜率除以盐水中样品的斜率来计算凝集数值指标。 结果数乘以100.通过从100减去该数值得到凝集指数（AI），使得AI的大小反映样品的凝集程度。 高指数值表示大的凝集（即与抗体的强相互作用）。 通过将AI与预定经验截断值进行比较来确定血型。 通常，大于17的截止值表示类型特异性相互作用（AB型样品产生具有抗A和抗B抗体的17个以上的AI值，而O型样品在抗A和抗B两者中产生小于17的AI值 抗体）。