公开(公告)号：US20230183652A1

公开(公告)日：2023-06-15

申请号：US18104015

申请日：2023-01-31

申请人： Lung Biotechnology PBC

发明人： Pingyong Xu ,  Luis Alvarez ,  Derek Morris ,  Iman Yazdi

IPC分类号： C12N5/09 ,  B33Y10/00 ,  B33Y70/00 ,  B29C64/124

CPC分类号： C12N5/0693 ,  B33Y10/00 ,  B33Y70/00 ,  B29C64/124 ,  B29L2031/7532

摘要： A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt % to about 3.0 wt % of one or more collagens; about 5.0 wt % to about 40.0 wt % of one or more monomers; about 0.5 wt % to about 2.0 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm2 (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.

公开(公告)号：US20200040306A1

公开(公告)日：2020-02-06

申请号：US16529415

申请日：2019-08-01

申请人： Lung Biotechnology PBC

发明人： Pingyong Xu ,  Luis Alvarez ,  Derek Morris ,  Iman Yazdi

IPC分类号： C12N5/09 ,  B33Y10/00 ,  B33Y70/00 ,  B29C64/124

摘要： A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt % to about 3.0 wt % of one or more collagens; about 5.0 wt % to about 40.0 wt % of one or more monomers; about 0.5 wt % to about 2.0 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm2 (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.

公开(公告)号：US11597915B2

公开(公告)日：2023-03-07

申请号：US16529415

申请日：2019-08-01

申请人： Lung Biotechnology PBC

发明人： Pingyong Xu ,  Luis Alvarez ,  Derek Morris ,  Iman Yazdi

IPC分类号： B33Y10/00 ,  C12N5/09 ,  B33Y70/00 ,  B29C64/124 ,  B29L31/00 ,  B33Y80/00 ,  B29K105/00

摘要： A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt % to about 3.0 wt % of one or more collagens; about 5.0 wt % to about 40.0 wt % of one or more monomers; about 0.5 wt % to about 2.0 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm2 (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.