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公开(公告)号：US20230256672A1
公开(公告)日：2023-08-17
申请号：US18108904
申请日：2023-02-13
发明人： Mohammadali Safavieh , Akarsh Sivaprasad , Mora Melican , Masoud Modaresifar , Datta Saravana Kalyan Kumar Vydiam , Barbara Nsiah , Derek Morris , Luis Alvarez
IPC分类号： B29C64/245 , B33Y30/00
CPC分类号： B29C64/245 , B33Y30/00 , B33Y10/00
摘要： A platform form an apparatus for printing a 3D model comprises a base and a print layer. The base has a first side where the first side of the base has a first surface roughness thereon. The print layer is coupled first side of the base and includes a surface. The surface of the print layer is distal from the base and has a second surface roughness which is greater than the first surface roughness so as to promote adhesion of the 3D model being printed on the platform.
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公开(公告)号：US20220055289A1
公开(公告)日：2022-02-24
申请号：US17410159
申请日：2021-08-24
发明人： Mohammadali Safavieh , Daniel E. Backman , Kalyan Vydiam , Masoud Modaresifar , Lara A. Murcin , Luis Alvarez , Derek Morris , Akarsh Sivaprasad
IPC分类号： B29C64/124 , B29C64/245 , B29C64/321 , B33Y10/00 , B33Y30/00 , B33Y40/00 , B33Y70/00 , B33Y80/00
摘要： Apparatus and method for forming a three-dimensional object. The apparatus includes a platform on which the three-dimensional object is formed. The apparatus includes an oxygen soluble liquid having a build surface. The build surface and the platform define a build region therebetween. The apparatus includes a photosensitive liquid disposed on the oxygen soluble liquid. The density of the oxygen soluble liquid is greater than the density of the photosensitive liquid. The apparatus includes an optically transparent member. The optically transparent member supports the oxygen soluble liquid. The apparatus includes a radiation source configured to irradiate the build region through the optically transparent member and the oxygen soluble liquid to form a solid polymer from the photosensitive liquid. The apparatus includes a controller configured to advance the platform away from the build surface.
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公开(公告)号：US20220281178A1
公开(公告)日：2022-09-08
申请号：US17686123
申请日：2022-03-03
发明人： Greg Hurst , Masoud Modaresifar , Mohammadali Safavieh , Derek Morris , Luis Alvarez , Daniel Backman
IPC分类号： B29C64/393 , B33Y50/02 , G06T17/00
摘要： An additive manufacturing device includes an output device and a controller. The output device is configured to receive at least one material to generate a component. The controller includes one or more processors configured to receive a model including a plurality of pixels representing the component, identify at least one pixel of the plurality of pixels corresponding to a first surface of the component, modify the model to adjust an exposure corresponding to the at least one pixel based on a target exposure, and control operation of the output device to cause the output device to generate the component based on the modified model.
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公开(公告)号：US20220355541A1
公开(公告)日：2022-11-10
申请号：US17738686
申请日：2022-05-06
发明人： Mora Carolynne Melican , Lara Murcin , Richmon Lin , Derek Morris , Barbara Nsiah , Lius Alvarez , Mohammadali Safavieh
IPC分类号： B29C64/129 , B29C64/264 , B33Y10/00 , B33Y70/00 , B33Y80/00 , A61F2/04 , A61L27/52 , A61L27/18
摘要： Embodiments of the present disclosure include methods of simultaneously manufacturing two or more hydrogel constructs (e.g., tubular hydrogel constructs). In some embodiments, the method comprises one or more of the following steps: providing a vat comprising a bio-ink composition containing one or more monomers and/or one or more polymers; applying electromagnetic radiation from an electromagnetic radiation source to cure a layer of the hydrogel constructs (e.g., tubular hydrogel constructs); and applying electromagnetic radiation from the electromagnetic radiation source one or more additional times to produce one or more additional layers of the hydrogel constructs (e.g., tubular hydrogel constructs).
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公开(公告)号：US20200040306A1
公开(公告)日：2020-02-06
申请号：US16529415
申请日：2019-08-01
发明人： Pingyong Xu , Luis Alvarez , Derek Morris , Iman Yazdi
IPC分类号： C12N5/09 , B33Y10/00 , B33Y70/00 , B29C64/124
摘要： A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt % to about 3.0 wt % of one or more collagens; about 5.0 wt % to about 40.0 wt % of one or more monomers; about 0.5 wt % to about 2.0 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm2 (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.
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6.发明授权公开(公告)号：US12083736B2
公开(公告)日：2024-09-10
申请号：US17971168
申请日：2022-10-21
IPC分类号： B29C64/124 , B29K105/00 , B33Y10/00 , B33Y70/00
CPC分类号： B29C64/124 , B33Y10/00 , B29K2105/0061 , B29K2105/0085 , B29K2995/0093 , B33Y70/00
摘要： A method of printing a hydrogel scaffold is provided which includes providing a container containing an ink and a liquid that is immiscible with the ink; applying light from a light source to the ink to form a portion of the hydrogel scaffold; and applying light from a light source one or more additional times to produce one or more additional portions of the hydrogel scaffold.
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公开(公告)号：US20230131073A1
公开(公告)日：2023-04-27
申请号：US17971168
申请日：2022-10-21
IPC分类号： B29C64/124 , B33Y10/00
摘要： A method of printing a hydrogel scaffold is provided which includes providing a container containing an ink and a liquid that is immiscible with the ink; applying light from a light source to the ink to form a portion of the hydrogel scaffold; and from a light source one or more additional times to produce one or more additional portions of the hydrogel scaffold.
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公开(公告)号：US11597915B2
公开(公告)日：2023-03-07
申请号：US16529415
申请日：2019-08-01
发明人： Pingyong Xu , Luis Alvarez , Derek Morris , Iman Yazdi
IPC分类号： B33Y10/00 , C12N5/09 , B33Y70/00 , B29C64/124 , B29L31/00 , B33Y80/00 , B29K105/00
摘要： A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt % to about 3.0 wt % of one or more collagens; about 5.0 wt % to about 40.0 wt % of one or more monomers; about 0.5 wt % to about 2.0 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm2 (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.
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公开(公告)号：US20240318143A1
公开(公告)日：2024-09-26
申请号：US18611429
申请日：2024-03-20
CPC分类号： C12N5/0688 , C07K1/042 , C07K7/06 , C07K7/08 , C07K14/00 , C12N2513/00 , C12N2533/50 , C12N2537/10
摘要： A method of modifying a surface of a three-dimensional (3D) article includes immersing at least one part of the 3D article in a buffered solution of functionalized peptides, allowing reaction between the functionalized peptides and reactive groups on the surface of the 3D article; and washing the at least one part of the 3D article to remove unreacted functionalized peptides. The surface-modified 3D article includes a plurality of peptides covalently bonded to the surface of the 3D article via a cysteine bridge. The surface-modified 3D article can be used as a scaffold for the formation of biological tissue or bodily implants.
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公开(公告)号：US20230183652A1
公开(公告)日：2023-06-15
申请号：US18104015
申请日：2023-01-31
发明人： Pingyong Xu , Luis Alvarez , Derek Morris , Iman Yazdi
IPC分类号： C12N5/09 , B33Y10/00 , B33Y70/00 , B29C64/124
CPC分类号： C12N5/0693 , B33Y10/00 , B33Y70/00 , B29C64/124 , B29L2031/7532
摘要： A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt % to about 3.0 wt % of one or more collagens; about 5.0 wt % to about 40.0 wt % of one or more monomers; about 0.5 wt % to about 2.0 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm2 (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.
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