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    Small interference RNA gene therapy
    1.
    发明授权
    Small interference RNA gene therapy 失效
    小干扰RNA基因治疗

    公开(公告)号：US07763722B2

    公开(公告)日：2010-07-27

    申请号：US10542461

    申请日：2004-01-15

    Applicant: Lung-Ji Chang ,  Jin He

    Inventor： Lung-Ji Chang ,  Jin He

    IPC: C07H21/04 ,  C07H21/02 ,  A61K48/00 ,  C12N15/63

    CPC classification number: C12N15/1135 ,  A61K48/00 ,  C12N15/111 ,  C12N15/1132 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2330/30 ,  C12N2799/027

    Abstract: Gene expression is inhibited in a cell by introducing into the cell a lentiviral vector encoding a siRNA specific for the gene. Lentiviral vectors encoding siRNA specific for a cancer-associated gene inhibited expression of the gene and caused cell death after being introduced into cancer cells. Viral replication in HIV-infected cells was inhibited after introducing a lentiviral vector encoding siRNA specific for HIV genes in into the cells.

    Abstract translation: 通过向细胞中导入编码针对该基因特异的siRNA的慢病毒载体，在细胞中抑制基因表达。 编码针对癌症相关基因的siRNA的慢病毒载体抑制基因的表达，并在导入癌细胞后导致细胞死亡。 在将HIV基因特异性siRNA的慢病毒载体导入细胞后，HIV感染细胞中的病毒复制被抑制。

    Small interference rna gene therapy
    2.
    发明申请
    Small interference rna gene therapy 失效
    小干扰rna基因治疗

    公开(公告)号：US20060269518A1

    公开(公告)日：2006-11-30

    申请号：US10542461

    申请日：2004-01-15

    Applicant: Lung-Ji Chang ,  Jin He

    Inventor： Lung-Ji Chang ,  Jin He

    IPC: A61K48/00 ,  C12N15/867

    CPC classification number: C12N15/1135 ,  A61K48/00 ,  C12N15/111 ,  C12N15/1132 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53 ,  C12N2330/30 ,  C12N2799/027

    Abstract: Gene expression is inhibited in a cell by introducing into the cell a lentiviral vector encoding a siRNA specific for the gene. Lentiviral vectors encoding siRNA specific for a cancer-associated gene inhibited expression of the gene and caused cell death after being introduced into cancer cells. Viral replication in HIV-infected cells was inhibited after introducing a lentiviral vector encoding siRNA specific for HIV genes in into the cells.

    Abstract translation: 通过向细胞中导入编码针对该基因特异的siRNA的慢病毒载体，在细胞中抑制基因表达。 编码针对癌症相关基因的siRNA的慢病毒载体抑制基因的表达，并在导入癌细胞后导致细胞死亡。 在将HIV基因特异性siRNA的慢病毒载体导入细胞后，HIV感染细胞中的病毒复制被抑制。

    MOLECULAR TRANSISTOR
    3.
    发明申请
    MOLECULAR TRANSISTOR 审中-公开
    分子晶体管

    公开(公告)号：US20140162247A1

    公开(公告)日：2014-06-12

    申请号：US14003851

    申请日：2012-03-09

    Applicant: Stuart Lindsay ,  Pei Pang ,  Jin He

    Inventor： Stuart Lindsay ,  Pei Pang ,  Jin He

    IPC: G01N27/414

    CPC classification number: G01N27/4146 ,  G01N33/48721

    Abstract: Fluidic nanotube devices and methods for their use are provided wherein the flow of charged molecules through a channel is controlled by the voltage potential of a gate electrode. In at least some embodiments, a molecular transistor is provided that includes a channel having a diameter such that only one target molecule at a time may traverse the channel. The channel may be a carbon nanotube that is electrically isolated from, and in communication with, a gate electrode. Methods are provided for controlling the flow of an individual molecule through the channel and for detecting a single chemical reaction.

    Abstract translation: 提供了流动的纳米管装置及其使用方法，其中通过通道的带电分子的流动由栅电极的电压电位来控制。 在至少一些实施例中，提供了一种分子晶体管，其包括具有使得一次只能有一个靶分子可以穿过该通道的直径的通道。 通道可以是与栅电极电隔离并与栅电极连通的碳纳米管。 提供了用于通过通道控制单个分子的流动并用于检测单个化学反应的方法。

    CONTROLLED TUNNEL GAP DEVICE FOR SEQUENCING POLYMERS
    5.
    发明申请
    CONTROLLED TUNNEL GAP DEVICE FOR SEQUENCING POLYMERS 有权
    用于测序聚合物的控制隧道缝隙装置

    公开(公告)号：US20120288948A1

    公开(公告)日：2012-11-15

    申请号：US13395956

    申请日：2011-01-31

    Applicant: Stuart Lindsay ,  Shuai Chang ,  Jin He ,  Peiming Zhang ,  Shuo Huang

    Inventor： Stuart Lindsay ,  Shuai Chang ,  Jin He ,  Peiming Zhang ,  Shuo Huang

    IPC: G01N27/00 ,  C25B7/00 ,  B82Y5/00

    CPC classification number: G01N33/48721 ,  C12Q1/6869 ,  G01N27/3275 ,  Y10T436/143333

    Abstract: The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo- or hetero-polymer such as DNA, RNA, a polysaccharide, or a peptide. The device includes electrodes that form a tunnel gap through which the polymer can pass. The electrodes are functionalized with a reagent attached thereto, and the reagent is capable of forming a transient bond to a polymer unit. When the transient bond forms between the reagent and the unit, a detectable signal is generated and used to analyze the polymer.

    Abstract translation: 本发明包括用于分析聚合物和/或聚合物单元的组合物，装置和方法。 聚合物可以是均聚物或异质聚合物，例如DNA，RNA，多糖或肽。 该装置包括形成隧道间隙的电极，聚合物可通过该间隙通过。 电极用附着于其上的试剂进行功能化，并且试剂能够形成与聚合物单元的暂时结合。 当试剂和单元之间形成瞬态键时，产生可检测的信号并用于分析聚合物。

    Nanopore and Carbon Nanotube Based DNA Sequencer
    6.
    发明申请
    Nanopore and Carbon Nanotube Based DNA Sequencer 有权
    纳米孔和碳纳米管的DNA测序仪

    公开(公告)号：US20110168562A1

    公开(公告)日：2011-07-14

    申请号：US12920817

    申请日：2009-03-18

    Applicant: Colin Nuckolls ,  Jinyao Tang ,  Stuart Lindsay ,  Jin He ,  Peiming Zhang ,  Kevin Reinhart

    Inventor： Colin Nuckolls ,  Jinyao Tang ,  Stuart Lindsay ,  Jin He ,  Peiming Zhang ,  Kevin Reinhart

    IPC: G01N27/00 ,  B32B37/24 ,  C23F1/00 ,  B82Y99/00

    CPC classification number: G01N33/48721 ,  C12Q1/6869 ,  C12Q2565/631

    Abstract: The present invention provides a device for analyzing the composition of a heteropolymer comprising a carbon nanotube through which the heteropolymer is driven by electrophoresis. The carbon nanotube also serves as one electrode in a reading circuit. One end of the carbon nanotube is held in close proximity to a second electrode, and each end of the carbon nanotube is functionalized with flexibly-tethered chemical-recognition moieties, such that one will bind one site on the emerging polymer, and the second will bind another site in close proximity, generating an electrical signal between the two electrodes when the circuit is completed by the process of chemical recognition.

    Abstract translation: 本发明提供一种用于分析包含碳纳米管的杂聚物的组成的装置，通过该电极驱动该杂聚物。 碳纳米管也用作读取电路中的一个电极。 碳纳米管的一端保持靠近第二电极，并且碳纳米管的每一端用柔性系带的化学识别部分功能化，使得将结合新出现的聚合物上的一个位点，而第二个 在另一个位置紧密接合，当通过化学识别过程完成电路时，在两个电极之间产生电信号。

    Phase-shifted post-regulator, method of operation thereof and power converter employing the same
    10.
    发明授权
    Phase-shifted post-regulator, method of operation thereof and power converter employing the same 有权
    相移后稳压器，其操作方法和使用该调整器的功率转换器

    公开(公告)号：US06178098B1

    公开(公告)日：2001-01-23

    申请号：US09401728

    申请日：1999-09-22

    Applicant: Jin He ,  Mark E. Jacobs

    Inventor： Jin He ,  Mark E. Jacobs

    IPC: H02M3335

    CPC classification number: H02M3/33561 ,  H02M2001/0093

    Abstract: For use in a power converter having an inverter coupled to an output rectifier, a post-regulator, a method of operating the same and a power converter incorporating the post-regulator or the method. In one embodiment: (1) a switching circuit, having at least one controllable switch and coupled an output of the power converter, that receives an output voltage from the power converter and produces a phase-shifted waveform therefrom and (2) a transformer, having a primary winding coupled to the switching circuit and a secondary winding coupled to the rectifier, that delivers the phase-shifted waveform to the rectifier to regulate the power converter, thereby allowing the inverter to be unregulated.

    Abstract translation: 用于具有耦合到输出整流器的逆变器的功率转换器，后调节器，其操作方法以及并入后稳压器或方法的功率转换器。 在一个实施例中：（1）开关电路，具有至少一个可控开关并耦合功率转换器的输出，其接收来自功率转换器的输出电压，并产生相移波形，以及（2）变压器， 具有耦合到开关电路的初级绕组和耦合到整流器的次级绕组，其将相移波形传送到整流器以调节功率转换器，从而允许逆变器不受调节。

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