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    DRUG RELEASING COATINGS FOR BALLOON CATHETERS
    3.
    发明申请
    DRUG RELEASING COATINGS FOR BALLOON CATHETERS 审中-公开

    公开(公告)号：US20200155811A1

    公开(公告)日：2020-05-21

    申请号：US16656289

    申请日：2019-10-17

    申请人： Lutonix, Inc.

    发明人： Lixiao Wang

    IPC分类号： A61M25/10 ,  A61L31/10 ,  A61F2/958 ,  A61F2/844 ,  A61L31/08 ,  A61L29/08 ,  A61L31/16 ,  A61L29/16 ,  A61K31/436 ,  A61K31/337

    摘要： Balloon catheters, methods for preparing balloon catheters, and uses of balloon catheters are disclosed. The balloon catheter includes an elongate member, an expandable balloon, and a coating layer overlying an exterior surface of the expandable balloon. The coating layer includes a total drug load of a hydrophobic therapeutic agent and a combination of additives including a first additive and a second additive. The hydrophobic therapeutic agent is paclitaxel, rapamycin, or paclitaxel and rapamycin. The first additive is a surfactant. The second additive is a chemical compound having one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide, or ester groups.

    MEDICAL DEVICE RAPID DRUG RELEASING COATINGS COMPRISING OILS, FATTY ACIDS, AND/OR LIPIDS
    7.
    发明申请
    MEDICAL DEVICE RAPID DRUG RELEASING COATINGS COMPRISING OILS, FATTY ACIDS, AND/OR LIPIDS 审中-公开
    包含油，脂肪酸和/或脂肪的医疗装置快速释放涂层

    公开(公告)号：US20130197435A1

    公开(公告)日：2013-08-01

    申请号：US13846104

    申请日：2013-03-18

    申请人： Lutonix, Inc.

    发明人： Lixiao Wang

    IPC分类号： A61L29/16

    CPC分类号： A61K31/337 ,  A61F2/82 ,  A61F2250/0067 ,  A61K31/436 ,  A61L29/08 ,  A61L29/16 ,  A61L31/08 ,  A61L31/16 ,  A61L2300/22 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/802 ,  A61M25/10 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/1031 ,  A61M2025/105 ,  A61K2300/00

    摘要： The invention relates to a coated medical device for rapid delivery of a therapeutic agent to a tissue in seconds to minutes. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, at least one of an oil, a fatty acid, and a lipid, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, a part that has an affinity to the therapeutic agent by charge, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is at least one of a surfactant and a chemical compound. In further embodiments, the chemical compound is water-soluble.

    摘要翻译： 本发明涉及用于将治疗剂快速递送至组织的涂覆的医疗装置，其数秒至数分钟。 医疗装置具有覆盖医疗装置的外表面的层。 该层含有治疗剂，油，脂肪酸和脂质中的至少一种和添加剂。 在某些实施方案中，添加剂具有亲水部分和药物亲和部分，其中药物亲和部分是疏水部分，通过氢键与治疗剂具有亲和性的部分中的至少一种，具有亲和力的部分 以及通过范德华力相互作用对治疗剂具有亲和力的部分。 在实施方案中，添加剂是表面活性剂和化合物中的至少一种。 在另外的实施方案中，化合物是水溶性的。

    DRUG RELEASING COATINGS FOR MEDICAL DEVICES
    8.
    发明申请
    DRUG RELEASING COATINGS FOR MEDICAL DEVICES 审中-公开

    公开(公告)号：US20130189329A1

    公开(公告)日：2013-07-25

    申请号：US13846089

    申请日：2013-03-18

    申请人： Lutonix, Inc.

    发明人： Lixiao Wang

    IPC分类号： A61L29/16 ,  A61L31/16

    CPC分类号： A61L31/16 ,  A61K31/337 ,  A61K31/436 ,  A61L29/16 ,  A61L31/08 ,  A61L2300/416 ,  A61L2300/80 ,  A61L2300/802 ,  A61K2300/00

    摘要： Medical device are provided for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from 80 to 750 or has more than four hydroxyl groups.