公开(公告)号：US07354714B2

公开(公告)日：2008-04-08

申请号：US10778936

申请日：2004-02-13

申请人： Lutz Gissmann ,  Kai Pohlmeyer ,  Martin Müller

发明人： Lutz Gissmann ,  Kai Pohlmeyer ,  Martin Müller

IPC分类号： C12Q1/68

CPC分类号： C07K16/084 ,  A61K39/12 ,  C12N2710/20034

摘要： A vaccine against disease caused by papilloma viruses is described in certain embodiments, as well as certain vectors, obtainable by the following methods: (a) one or more expression vectors that contain the DNA code for a structural protein of papilloma viruses or a fragment thereof are injected into mammals, whereby in at least some of the expression vectors randomly generated heterologous sequences are inserted into the DNA code (b) serums are obtained from the mammals and these are tested for the presence of antibodies against particles of various papilloma virus types, and (c) using the serums tested, the structural protein gene clones are identified that code for a polyvalent vaccine, and (d) the vaccine is produced from them. Procedures for producing a vaccine is also described, together with its use for vaccination against diseases caused by papilloma viruses.

摘要翻译： 在某些实施方案中描述了针对由乳头瘤病毒引起的疾病的疫苗，以及可通过以下方法获得的某些载体：（a）含有乳头状瘤病毒或其片段的结构蛋白的DNA编码的一种或多种表达载体 注射到哺乳动物中，由此在至少一些表达载体中随机产生的异源序列插入到DNA代码（b）中，从哺乳动物获得血清，并测试这些血清是否存在针对各种乳头状瘤病毒类型的颗粒的抗体， 和（c）使用测试的血清，鉴定编码多价疫苗的结构蛋白质基因克隆，和（d）从它们产生疫苗。 还描述了生产疫苗的程序，以及其用于针对由乳头瘤病毒引起的疾病的疫苗接种的用途。

公开(公告)号：US06322794B1

公开(公告)日：2001-11-27

申请号：US08164768

申请日：1993-12-10

申请人： Conrad Bleul ,  Lutz Gissmann ,  Martin Müller

发明人： Conrad Bleul ,  Lutz Gissmann ,  Martin Müller

IPC分类号： A61K3912

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2710/20022

摘要： The invention relates to seroreactive epitopes on proteins of human papillomavirus HPV18. In addition, the invention relates to peptides which have amino-acid sequences which coincide in whole or in part with the sequences of the seroreactive epitopes, and to vaccines which contain such peptides.

摘要翻译： 本发明涉及人乳头状瘤病毒HPV18蛋白质上的血清反应性表位。此外，本发明涉及具有全部或部分与血清反应性表位的序列重合的氨基酸序列的肽以及含有这些肽的疫苗。

公开(公告)号：US07320861B2

公开(公告)日：2008-01-22

申请号：US10485454

申请日：2002-07-26

申请人： Lutz Gissmann ,  Kai Pohlmeyer ,  Martin Müller

发明人： Lutz Gissmann ,  Kai Pohlmeyer ,  Martin Müller

IPC分类号： C12Q1/68

CPC分类号： C07K16/084 ,  A61K39/12 ,  C12N2710/20034

摘要： A vaccine against disease caused by papilloma viruses is described in certain embodiments, as well as certain vectors, obtainable by the following methods: (a) one or more expression vectors that contain the DNA code for a structural protein of papilloma viruses or a fragment thereof are injected into mammals, whereby in at least some of the expression vectors randomly generated heterologous sequences are inserted into the DNA code (b) serums are obtained from the mammals and these are tested for the presence of antibodies against particles of various papilloma virus types, and (c) using the serums tested, the structural protein gene clones are identified that code for a polyvalent vaccine, and (d) the vaccine is produced from them. Procedures for producing a vaccine is also described, together with its use for vaccination against diseases caused by papilloma viruses.

摘要翻译： 在某些实施方案中描述了针对由乳头瘤病毒引起的疾病的疫苗，以及可通过以下方法获得的某些载体：（a）含有乳头状瘤病毒或其片段的结构蛋白的DNA编码的一种或多种表达载体 注射到哺乳动物中，由此在至少一些表达载体中随机产生的异源序列插入到DNA代码（b）中，从哺乳动物获得血清，并测试这些血清是否存在针对各种乳头状瘤病毒类型的颗粒的抗体， 和（c）使用测试的血清，鉴定编码多价疫苗的结构蛋白质基因克隆，和（d）从它们产生疫苗。 还描述了生产疫苗的程序，以及其用于针对由乳头瘤病毒引起的疾病的疫苗接种的用途。

公开(公告)号：US06723317B2

公开(公告)日：2004-04-20

申请号：US10340783

申请日：2003-01-13

申请人： Martin Müller ,  Lutz Gissmann

发明人： Martin Müller ,  Lutz Gissmann

IPC分类号： A61K39395

CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K2039/5256 ,  C07K14/005 ,  C07K16/084 ,  C12N2710/20022

摘要： The invention relates to seroreactive regions on proteins E1 and E2 of human papillomavirus (HPV) 16. The application also relates to a vaccine which contains such peptides which contain the seroreactive regions. The invention likewise embraces compositions for diagnostic purposes which contain peptides with the seroreactive regions.

摘要翻译： 本发明涉及人乳头状瘤病毒（HPV）16的蛋白质E1和E2上的血清反应性区域。本申请还涉及含有含有血清反应性区域的肽的疫苗。 本发明同样包含用于诊断目的的组合物，其含有具有血清反应性区域的肽。

公开(公告)号：US06221577B1

公开(公告)日：2001-04-24

申请号：US08468337

申请日：1995-06-06

申请人： Martin Müller ,  Lutz Gissmann

发明人： Martin Müller ,  Lutz Gissmann

IPC分类号： C12Q170

CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K2039/5256 ,  C07K14/005 ,  C07K16/084 ,  C12N2710/20022

摘要： The invention relates to seroreactive regions on protein E1 and E2 of human papillomavirus (HPV) 16. The application also relates to a vaccine which contains such peptides which contain the seroreactive regions. The invention likewise embraces compositions for diagnostic purposes which contain peptides with the seroreactive regions.

摘要翻译： 本发明涉及人乳头瘤病毒（HPV）16蛋白E1和E2上的血清反应性区域。本申请还涉及含有含有血清反应性区域的肽的疫苗。 本发明同样包含用于诊断目的的组合物，其含有具有血清反应性区域的肽。

公开(公告)号：US06228368B1

公开(公告)日：2001-05-08

申请号：US08944368

申请日：1997-10-06

申请人： Lutz Gissmann ,  Martin Müller

发明人： Lutz Gissmann ,  Martin Müller

IPC分类号： A61K3912

CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K2039/5258 ,  C07K14/005 ,  C07K2319/00 ,  C12N2710/20022 ,  C12N2710/20023 ,  Y10S977/802 ,  Y10S977/917

摘要： Vaccine formulations comprising viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed.

摘要翻译： 公开了包含病毒壳聚糖的疫苗制剂及其制备方法。 还公开了用于疫苗制剂的治疗和预防方法。

公开(公告)号：US06531127B2

公开(公告)日：2003-03-11

申请号：US09758318

申请日：2001-01-12

申请人： Martin Müller ,  Lutz Gissmann

发明人： Martin Müller ,  Lutz Gissmann

IPC分类号： A61K39395

CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K2039/5256 ,  C07K14/005 ,  C07K16/084 ,  C12N2710/20022

摘要： The invention relates to seroreactive regions on the E1 and E2 proteins of human papillomavirus 16 (HPV 16). The invention also relates to a vaccine that contains peptides comprising at least one seroreactive region of the E1 and/or E2 proteins. The invention likewise embraces compositions for diagnostic purposes, which contain peptides with the seroreactive regions. Further, the invention relates to antibodies that bind to seroreactive regions of the E1 and/or E2 proteins of HPV 16, and compositions comprising such antibodies, which can be used for diagnostic purposes.

摘要翻译： 本发明涉及人乳头状瘤病毒16（HPV16）的E1和E2蛋白上的血清反应性区域。 本发明还涉及含有包含至少一种E1和/或E2蛋白的血清反应性区域的肽的疫苗。 本发明同样包含用于诊断目的的组合物，其含有具有血清反应性区域的肽。 此外，本发明涉及结合HPV16的E1和/或E2蛋白的血清反应性区域的抗体，以及可用于诊断目的的包含此类抗体的组合物。

公开(公告)号：US09247905B2

公开(公告)日：2016-02-02

申请号：US13264788

申请日：2009-04-17

申请人： Andreas Caduff ,  Mark Stuart Talary ,  Martin Müller ,  Oscar De Feo

发明人： Andreas Caduff ,  Mark Stuart Talary ,  Martin Müller ,  Oscar De Feo

IPC分类号： A61B5/02 ,  A61B5/00 ,  A61B5/05 ,  A61B5/053 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/01

CPC分类号： A61B5/4869 ,  A61B5/01 ,  A61B5/0507 ,  A61B5/0531 ,  A61B5/0537 ,  A61B5/14532 ,  A61B5/1455 ,  A61B2560/0252 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/046

摘要： A method and device for determining the glucose level in living tissue are based on measuring the response of the tissue an electric field as well as temperature measurements. In order to improve accuracy, it has been found that measurements in at least three frequency ranges between 1 kHz and 200 kHz, 0.2 MHz an 100 MHz as well as above 1 GHz should be combined since the response of the tissue in these different frequency ranges is ruled by differing mechanisms.

摘要翻译： 用于测定活组织中葡萄糖水平的方法和装置是基于测量组织的电场响应以及温度测量。 为了提高精度，已经发现，应该组合1kHz至200kHz，0.2MHz，100MHz以及1GHz以上的至少三个频率范围内的测量，因为在这些不同频率范围内组织的响应 由不同的机制统治。

公开(公告)号：US08630976B2

公开(公告)日：2014-01-14

申请号：US12195111

申请日：2008-08-20

申请人： Martin Müller ,  Maic Wintel

发明人： Martin Müller ,  Maic Wintel

IPC分类号： G06F7/00

CPC分类号： G06F17/30371 ,  G06F17/30445

摘要： A method and medium for performing a replication process are provided. The method includes receiving a request to perform an initial load of a first persistence of at least one business object node to replicate the at least one business object node to a second persistence of the business object node; providing a queue to store updates of the at least one business object node; setting a lock for the at least one business object node, the lock indicating a replicating process is performing the initial load of the at least one business object node; determining whether the lock is set for the at least one business object node; and storing, in the queue, the updates of the at least one business object node that occur in parallel with the replicating process in an instance it is determined the lock is set for the at least one business object node.

摘要翻译： 提供了用于执行复制过程的方法和介质。 所述方法包括：接收执行至少一个业务对象节点的第一持久性的初始加载以将所述至少一个业务对象节点复制到所述业务对象节点的第二持久性的请求; 提供队列以存储所述至少一个业务对象节点的更新; 为所述至少一个业务对象节点设置锁定，指示复制过程的所述锁正在执行所述至少一个业务对象节点的初始加载; 确定是否为所述至少一个业务对象节点设置所述锁定; 以及在一个实例中，在队列中存储与所述复制过程并行发生的所述至少一个业务对象节点的更新，确定为所述至少一个业务对象节点设置所述锁定。

公开(公告)号：US08382084B2

公开(公告)日：2013-02-26

申请号：US12598928

申请日：2008-02-19

申请人： Markus Gerber ,  Adrian Stauffer ,  Martin Müller

发明人： Markus Gerber ,  Adrian Stauffer ,  Martin Müller

IPC分类号： B23Q1/25

CPC分类号： B21D43/003 ,  Y10T29/49998

摘要： A centering device (1) for flat workpieces, especially sheet-metal blanks to be processed in a press, comprises a first table, which can be rotated about a first vertical axis, for receiving a workpiece and a second table, which can be rotated about a second vertical axis, for receiving a workpiece. The second table is arranged to the side of the first table, and a support level of the first table coincides substantially with a support level of the second table. The device furthermore comprises a rotation mechanism coupled mechanically to the first table and to the second table allowing the first and the second tables to be rotated jointly about a third vertical axis to form a common supporting surface. In an alternative operating mode, the tables are rotated individually about the spaced vertical axes of rotation and thus move relative to one another.

摘要翻译： 一种用于平坦工件的定心装置（1），特别是在冲压机中加工的金属板坯料，包括可绕第一垂直轴线旋转的第一工作台，用于容纳工件和可旋转的第二工作台 围绕第二垂直轴线，用于接收工件。 第二表布置在第一表的一侧，并且第一表的支撑水平基本上与第二表的支撑水平重合。 该装置还包括机械地联接到第一工作台和第二工作台的旋转机构，允许第一和第二工作台围绕第三垂直轴线共同旋转以形成共同的支撑表面。 在替代的操作模式中，桌子围绕间隔开的垂直旋转轴线单独旋转，并因此相对于彼此移动。