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公开(公告)号：US08906349B2
公开(公告)日：2014-12-09
申请号：US13387780
申请日：2009-08-12
申请人： Lyndsay Schaeffer-Korbylo , Andre Michelle Morgan , Davide Miksa , Laurence Du-Thumm , Michael Prencipe , Evangelia S. Arvanitidou , Gregory Szewczyk
发明人： Lyndsay Schaeffer-Korbylo , Andre Michelle Morgan , Davide Miksa , Laurence Du-Thumm , Michael Prencipe , Evangelia S. Arvanitidou , Gregory Szewczyk
CPC分类号： A61K8/34 , A01N49/00 , A61K8/19 , A61K8/21 , A61K8/33 , A61K8/342 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/4926 , A61K8/97 , A61K2800/92 , A61Q11/00 , A01N31/08 , A01N31/16 , A01N43/40 , A01N59/16 , A01N65/00 , A01N2300/00 , A01N65/08
摘要： Disclosed are oral care compositions and the use of such oral care compositions for treating conditions caused by biofilm formation. Also disclosed are methods for inhibiting biofilm formation and/or degrading biofilm. The oral care composition includes a sesquiterpenoid and an antimicrobial agent, in which the sesquiterpenoid and the antimicrobial agent are present in an amount effective to inhibit and/or degrade a biofilm in the oral cavity.
摘要翻译： 公开了口腔护理组合物和这种口腔护理组合物用于治疗由生物膜形成引起的病症的用途。 还公开了抑制生物膜形成和/或降解生物膜的方法。 口腔护理组合物包括倍半萜和抗微生物剂，其中倍半萜烯和抗微生物剂以有效抑制和/或降解口腔中生物膜的量存在。
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公开(公告)号：US20120128599A1
公开(公告)日：2012-05-24
申请号：US13387780
申请日：2009-08-12
申请人： Lyndsay Schaeffer-Korbylo , Andre Michelle Morgan , Davide Miksa , Laurence Du-Thumm , Michael Prencipe , Evangelia S. Arvanitidou , Gregory Szewczyk
发明人： Lyndsay Schaeffer-Korbylo , Andre Michelle Morgan , Davide Miksa , Laurence Du-Thumm , Michael Prencipe , Evangelia S. Arvanitidou , Gregory Szewczyk
CPC分类号： A61K8/34 , A01N49/00 , A61K8/19 , A61K8/21 , A61K8/33 , A61K8/342 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/4926 , A61K8/97 , A61K2800/92 , A61Q11/00 , A01N31/08 , A01N31/16 , A01N43/40 , A01N59/16 , A01N65/00 , A01N2300/00 , A01N65/08
摘要： Disclosed are oral care compositions and the use of such oral care compositions for treating conditions caused by biofilm formation. Also disclosed are methods for inhibiting biofilm formation and/or degrading biofilm. The oral care composition includes a sesquiterpenoid and an antimicrobial agent, in which the sesquiterpenoid and the antimicrobial agent are present in an amount effective to inhibit and/or degrade a biofilm in the oral cavity.
摘要翻译： 公开了口腔护理组合物和这种口腔护理组合物用于治疗由生物膜形成引起的病症的用途。 还公开了抑制生物膜形成和/或降解生物膜的方法。 口腔护理组合物包括倍半萜和抗微生物剂，其中倍半萜烯和抗微生物剂以有效抑制和/或降解口腔中生物膜的量存在。
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公开(公告)号：US20110165099A1
公开(公告)日：2011-07-07
申请号：US12983460
申请日：2011-01-03
CPC分类号： A61K8/97 , A61K8/19 , A61K8/20 , A61K8/21 , A61K8/23 , A61K8/25 , A61K8/33 , A61K8/347 , A61K2800/28 , A61K2800/43 , A61K2800/48 , A61K2800/522 , A61Q11/00
摘要： Low water tooth pastes contain a variety of plant extracts. The oral or dentifrice compositions containing humectants, abrasive compounds, and a variety of plant extracts, such as rosemary and green tea extracts, along with an additional antioxidant component. Examples of antioxidants include stannous compounds, sodium meta-bisulfite, BHT, ammonium sulfate, and potassium stannate. The compositions are resistant to browning. The invention also provides methods for promoting oral health of a subject animal comprising applying a composition as discussed above to the oral surfaces of the animal.
摘要翻译： 低水牙膏含有各种植物提取物。 含有湿润剂，磨料化合物和各种植物提取物如迷迭香和绿茶提取物的口服或牙粉组合物以及另外的抗氧化成分。 抗氧化剂的实例包括亚锡化合物，偏亚硫酸氢钠，BHT，硫酸铵和锡酸锡。 组合物耐褐变。 本发明还提供用于促进受试动物的口腔健康的方法，包括将如上所述的组合物施用于动物的口腔表面。
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公开(公告)号：US08974772B2
公开(公告)日：2015-03-10
申请号：US11023968
申请日：2004-12-28
申请人： Linh Fruge , James R. Brown , Susan Herles , Kimberlee Panaligan , Evangelia S. Arvanitidou , Nebojsa Milanovich , Michael Prencipe
发明人： Linh Fruge , James R. Brown , Susan Herles , Kimberlee Panaligan , Evangelia S. Arvanitidou , Nebojsa Milanovich , Michael Prencipe
CPC分类号： A61K8/21 , A61K8/19 , A61K8/347 , A61K2800/88 , A61Q11/00
摘要： An oral care composition having a first phase of clinically efficacious 2,4,4′-trichloro 2′-hydroxydiphenyl ether admixed in a first orally acceptable aqueous vehicle, and a second phase having a stannous salt (such as stannous fluoride) admixed in a second orally acceptable aqueous vehicle. The second phase has no less than 10 molar percent of soluble stannous ion respective to a mathematical sum of moles of the soluble stannous ion and moles of the stannous salt in the second phase. In one embodiment, the two phases are provided in a dual-tube toothpaste oral care kit.
摘要翻译： 一种口腔护理组合物，其具有混合在第一口服可接受的水性载体中的临床上有效的2,4,4'-三氯2'-羟基二苯醚的第一相，和在其中混合的具有亚锡盐（例如氟化亚锡）的第二相 第二种口服可接受的水性载体。 第二相具有不少于10摩尔％的可溶性亚锡离子，相对于第二相中可溶性亚锡离子的摩尔数和亚锡盐的摩尔数的数学和。 在一个实施方案中，将两相设置在双管牙膏口腔护理套件中。
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公开(公告)号：US09486396B2
公开(公告)日：2016-11-08
申请号：US13996036
申请日：2010-12-21
申请人： Venda Porter Maloney , Vyoma Patel , Steven Wade Fisher , Andre Michelle Morgan , Michael Prencipe , Stanislav Jaracz
发明人： Venda Porter Maloney , Vyoma Patel , Steven Wade Fisher , Andre Michelle Morgan , Michael Prencipe , Stanislav Jaracz
CPC分类号： A61K8/58 , A61K8/24 , A61K8/27 , A61K8/36 , A61K8/361 , A61K8/362 , A61K8/365 , A61K8/44 , A61Q11/00
摘要： Described herein are compositions comprising combinations of metal salts, and methods of preparing and using the same.
摘要翻译： 本文描述的是包含金属盐的组合的组合物，以及制备和使用它们的方法。
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公开(公告)号：US20130287709A1
公开(公告)日：2013-10-31
申请号：US13996036
申请日：2010-12-21
申请人： Venda Porter Maloney , Vyoma Patel , Steven Wade Fisher , Andre Michelle Morgan , Michael Prencipe , Stanislav Jaracz
发明人： Venda Porter Maloney , Vyoma Patel , Steven Wade Fisher , Andre Michelle Morgan , Michael Prencipe , Stanislav Jaracz
CPC分类号： A61K8/58 , A61K8/24 , A61K8/27 , A61K8/36 , A61K8/361 , A61K8/362 , A61K8/365 , A61K8/44 , A61Q11/00
摘要： Described herein are compositions comprising combinations of metal salts, and methods of preparing and using the same.
摘要翻译： 本文描述的是包含金属盐的组合的组合物，以及制备和使用它们的方法。
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公开(公告)号：US09744112B2
公开(公告)日：2017-08-29
申请号：US14365116
申请日：2011-12-16
CPC分类号： A61K8/58 , A61K8/02 , A61K8/0216 , A61K8/494 , A61K8/731 , A61K2800/43 , A61K2800/58 , A61Q11/00
摘要： Described herein are compositions comprising a film, wherein the film comprises a pigment, and is adapted to release the pigment at a specific point in time during use; and methods of making and using the same.
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公开(公告)号：US09750825B2
公开(公告)日：2017-09-05
申请号：US14365113
申请日：2011-12-16
CPC分类号： A61K49/00 , A61K8/0204 , A61K8/0233 , A61K8/345 , A61K8/4993 , A61K8/731 , A61K8/732 , A61K2800/43 , A61Q11/00 , B65D35/00
摘要： Described herein are dentifrices comprising a first formulation and a second formulation, wherein the formulations are coaxially extruded, so that the first formulation enrobes the second formulation, wherein the first formulation is opaque and wherein the second formulation comprises dissolvable film fragments, together with methods of making and using the same and containers for providing the same.
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公开(公告)号：US09522111B2
公开(公告)日：2016-12-20
申请号：US14365082
申请日：2011-12-16
IPC分类号： A61K8/73 , A61Q11/00 , A61K8/72 , A61K8/21 , A61K8/34 , A61Q17/00 , A61K8/81 , A61K8/02 , A61K8/46 , A61K8/49
CPC分类号： A61K8/731 , A61K8/0216 , A61K8/345 , A61K8/347 , A61K8/463 , A61K8/4973 , A61K8/8164 , A61K2800/43 , A61K2800/5424 , A61Q11/00 , A61Q17/005
摘要： Described herein are oral care compositions comprising an antibacterial agent and a dissolvable film comprising a pigment which provide a color change signal after a sufficient period of brushing, wherein the dentifrice base has water activity less than 0.78 and comprises anionic polymer in free or salt form 10-25% by weight of the dentifrice base, and anionic surfactant less than 3% by weight; together with methods of making and using the compositions.
摘要翻译： 本文描述了包含抗菌剂和可溶性膜的口腔护理组合物，其包含在充分的刷牙时间后提供变色信号的颜料，其中洁齿剂碱的水分活度小于0.78，并且包含游离或盐形式的阴离子聚合物10 -25重量％的洁牙剂碱，阴离子表面活性剂小于3重量％; 以及制备和使用组合物的方法。
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公开(公告)号：US20150086486A1
公开(公告)日：2015-03-26
申请号：US14365082
申请日：2011-12-16
CPC分类号： A61K8/731 , A61K8/0216 , A61K8/345 , A61K8/347 , A61K8/463 , A61K8/4973 , A61K8/8164 , A61K2800/43 , A61K2800/5424 , A61Q11/00 , A61Q17/005
摘要： Described herein are oral care compositions comprising an antibacterial agent and a dissolvable film comprising a pigment which provide a color change signal after a sufficient period of brushing, wherein the dentifrice base has water activity less than 0.78 and comprises anionic polymer in free or salt form 10-25% by weight of the dentifrice base, and anionic surfactant less than 3% by weight; together with methods of making and using the compositions.
摘要翻译： 本文描述了包含抗菌剂和可溶性膜的口腔护理组合物，其包含在充分的刷牙时间后提供变色信号的颜料，其中洁齿剂碱的水分活度小于0.78，并且包含游离或盐形式的阴离子聚合物10 -25重量％的洁牙剂碱，阴离子表面活性剂小于3重量％; 以及制备和使用组合物的方法。
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