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公开(公告)号：US08148107B2
公开(公告)日：2012-04-03
申请号：US13166905
申请日：2011-06-23
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/545 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.
摘要翻译： 抗体的人抗体或抗原结合片段，其通过表面等离振子共振测定的KD为5pM以下的特异性结合人神经生长因子（NGF），其中所述抗体或其片段以大约的亲和力结合人NGF 抗体或片段的2-10倍高于大鼠和小鼠NGF。 抗体可用于治疗疼痛，包括炎性疼痛，手术后切口疼痛，神经性疼痛，骨折疼痛，骨质疏松性骨折疼痛，疱疹后神经痛，骨关节炎，类风湿性关节炎，癌症疼痛，由灼伤引起的疼痛，痛风痛， 以及肝细胞癌，乳腺癌和肝硬化等疾病。
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公开(公告)号：US20090041717A1
公开(公告)日：2009-02-12
申请号：US12188330
申请日：2008-08-08
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/545 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.
摘要翻译： 抗体的人抗体或抗原结合片段，其通过表面等离振子共振测定的KD为5pM以下的特异性结合人神经生长因子（NGF），其中所述抗体或其片段以大约的亲和力结合人NGF 抗体或片段的2-10倍高于大鼠和小鼠NGF。 抗体可用于治疗疼痛，包括炎性疼痛，手术后切口疼痛，神经性疼痛，骨折疼痛，骨质疏松性骨折疼痛，疱疹后神经痛，骨关节炎，类风湿性关节炎，癌症疼痛，由灼伤引起的疼痛，痛风痛， 以及肝细胞癌，乳腺癌和肝硬化等疾病。
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公开(公告)号：US08613927B2
公开(公告)日：2013-12-24
申请号：US13406734
申请日：2012-02-28
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/545 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.
摘要翻译： 抗体的人抗体或抗原结合片段，其通过表面等离振子共振测定的KD为5pM以下的特异性结合人神经生长因子（NGF），其中所述抗体或其片段以大约的亲和力结合人NGF 抗体或片段的2-10倍高于大鼠和小鼠NGF。 抗体可用于治疗疼痛，包括炎性疼痛，手术后切口疼痛，神经性疼痛，骨折疼痛，骨质疏松性骨折疼痛，疱疹后神经痛，骨关节炎，类风湿性关节炎，癌症疼痛，由灼伤引起的疼痛，痛风痛， 以及肝细胞癌，乳腺癌和肝硬化等疾病。
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公开(公告)号：US20110256587A1
公开(公告)日：2011-10-20
申请号：US13166905
申请日：2011-06-23
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/545 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.
摘要翻译： 抗体的人抗体或抗原结合片段，其通过表面等离振子共振测定的KD为5pM以下的特异性结合人神经生长因子（NGF），其中所述抗体或其片段以大约的亲和力结合人NGF 抗体或片段的2-10倍高于大鼠和小鼠NGF。 抗体可用于治疗疼痛，包括炎性疼痛，手术后切口疼痛，神经性疼痛，骨折疼痛，骨质疏松性骨折疼痛，疱疹后神经痛，骨关节炎，类风湿性关节炎，癌症疼痛，由灼伤引起的疼痛，痛风痛， 以及肝细胞癌，乳腺癌和肝硬化等疾病。
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公开(公告)号：US08309088B2
公开(公告)日：2012-11-13
申请号：US12888751
申请日：2010-09-23
申请人： Lynn MacDonald , Richard Torres , Marc R. Morra , Joel H. Martin , Joel C. Reinhardt , Paul Tiseo
发明人： Lynn MacDonald , Richard Torres , Marc R. Morra , Joel H. Martin , Joel C. Reinhardt , Paul Tiseo
CPC分类号： C07K16/22 , A61K9/0019 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/545 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： Methods are disclosed for treating osteoarthritis in a human subject in need thereof, comprising administering to the subject a therapeutically effective amount of an anti-human NGF antibody, or antigen-binding fragment thereof, wherein at least one symptom associated with osteoarthritis is prevented, ameliorated or improved.
摘要翻译： 公开了用于治疗有需要的人类受试者骨关节炎的方法，其包括向受试者施用治疗有效量的抗人NGF抗体或其抗原结合片段，其中至少一种与骨关节炎有关的症状被预防，改善 或改进。
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公开(公告)号：US20120164688A1
公开(公告)日：2012-06-28
申请号：US13406734
申请日：2012-02-28
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/545 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.
摘要翻译： 抗体的人抗体或抗原结合片段，其通过表面等离振子共振测定的KD为5pM以下的特异性结合人神经生长因子（NGF），其中所述抗体或其片段以大约的亲和力结合人NGF 抗体或片段的2-10倍高于大鼠和小鼠NGF。 抗体可用于治疗疼痛，包括炎性疼痛，手术后切口疼痛，神经性疼痛，骨折疼痛，骨质疏松性骨折疼痛，疱疹后神经痛，骨关节炎，类风湿性关节炎，癌症疼痛，由灼伤引起的疼痛，痛风痛， 以及肝细胞癌，乳腺癌和肝硬化等疾病。
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