利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.034 秒)

    HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR
    1.
    发明申请
    HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR 有权
    人类神经生长因子的高亲和力人体抗体

    公开(公告)号：US20090041717A1

    公开(公告)日：2009-02-12

    申请号：US12188330

    申请日：2008-08-08

    申请人： Lynn MacDonald ,  Richard Torres ,  Marc R. Morra ,  Joel H. Martin ,  Joel C. Reinhardt

    发明人： Lynn MacDonald ,  Richard Torres ,  Marc R. Morra ,  Joel H. Martin ,  Joel C. Reinhardt

    IPC分类号： A61K45/00 ,  C07K16/18 ,  C12N15/11 ,  C12N15/00 ,  A61P43/00 ,  C12P21/04 ,  A61K39/395

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

    摘要： A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.

    摘要翻译： 抗体的人抗体或抗原结合片段，其通过表面等离振子共振测定的KD为5pM以下的特异性结合人神经生长因子（NGF），其中所述抗体或其片段以大约的亲和力结合人NGF 抗体或片段的2-10倍高于大鼠和小鼠NGF。 抗体可用于治疗疼痛，包括炎性疼痛，手术后切口疼痛，神经性疼痛，骨折疼痛，骨质疏松性骨折疼痛，疱疹后神经痛，骨关节炎，类风湿性关节炎，癌症疼痛，由灼伤引起的疼痛，痛风痛， 以及肝细胞癌，乳腺癌和肝硬化等疾病。

    High affinity human antibodies to human nerve growth factor
    2.
    发明授权
    High affinity human antibodies to human nerve growth factor 有权
    人类神经生长因子高亲和力抗体

    公开(公告)号：US08148107B2

    公开(公告)日：2012-04-03

    申请号：US13166905

    申请日：2011-06-23

    申请人： Lynn Macdonald ,  Richard Torres ,  Marc R. Morra ,  Joel H. Martin ,  Joel C. Reinhardt

    发明人： Lynn Macdonald ,  Richard Torres ,  Marc R. Morra ,  Joel H. Martin ,  Joel C. Reinhardt

    IPC分类号： C07H21/04 ,  C12N15/13 ,  C12N5/10 ,  C12N5/07 ,  C12N1/21

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

    摘要： A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.

    摘要翻译： 抗体的人抗体或抗原结合片段，其通过表面等离振子共振测定的KD为5pM以下的特异性结合人神经生长因子（NGF），其中所述抗体或其片段以大约的亲和力结合人NGF 抗体或片段的2-10倍高于大鼠和小鼠NGF。 抗体可用于治疗疼痛，包括炎性疼痛，手术后切口疼痛，神经性疼痛，骨折疼痛，骨质疏松性骨折疼痛，疱疹后神经痛，骨关节炎，类风湿性关节炎，癌症疼痛，由灼伤引起的疼痛，痛风痛， 以及肝细胞癌，乳腺癌和肝硬化等疾病。

    High affinity human antibodies to human nerve growth factor
    3.
    发明授权
    High affinity human antibodies to human nerve growth factor 有权
    人类神经生长因子高亲和力抗体

    公开(公告)号：US08613927B2

    公开(公告)日：2013-12-24

    申请号：US13406734

    申请日：2012-02-28

    申请人： Lynn MacDonald ,  Richard Torres ,  Marc R. Morra ,  Joel H. Martin ,  Joel C. Reinhardt

    发明人： Lynn MacDonald ,  Richard Torres ,  Marc R. Morra ,  Joel H. Martin ,  Joel C. Reinhardt

    IPC分类号： A61K39/395 ,  A61P25/02 ,  A61P25/04 ,  A61P29/00 ,  A61P19/02 ,  A61P19/06

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

    摘要： A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.

    摘要翻译： 抗体的人抗体或抗原结合片段，其通过表面等离振子共振测定的KD为5pM以下的特异性结合人神经生长因子（NGF），其中所述抗体或其片段以大约的亲和力结合人NGF 抗体或片段的2-10倍高于大鼠和小鼠NGF。 抗体可用于治疗疼痛，包括炎性疼痛，手术后切口疼痛，神经性疼痛，骨折疼痛，骨质疏松性骨折疼痛，疱疹后神经痛，骨关节炎，类风湿性关节炎，癌症疼痛，由灼伤引起的疼痛，痛风痛， 以及肝细胞癌，乳腺癌和肝硬化等疾病。

    HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR
    4.
    发明申请
    HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR 有权
    人类神经生长因子的高亲和力人体抗体

    公开(公告)号：US20110256587A1

    公开(公告)日：2011-10-20

    申请号：US13166905

    申请日：2011-06-23

    申请人： Lynn Macdonald ,  Richard Torres ,  Marc R. Morra ,  Joel H. Martin ,  Joel C. Reinhardt

    发明人： Lynn Macdonald ,  Richard Torres ,  Marc R. Morra ,  Joel H. Martin ,  Joel C. Reinhardt

    IPC分类号： C12P21/02 ,  C07H21/04 ,  C12N5/10 ,  C12N15/63 ,  C12N1/00

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

    摘要： A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.

    摘要翻译： 抗体的人抗体或抗原结合片段，其通过表面等离振子共振测定的KD为5pM以下的特异性结合人神经生长因子（NGF），其中所述抗体或其片段以大约的亲和力结合人NGF 抗体或片段的2-10倍高于大鼠和小鼠NGF。 抗体可用于治疗疼痛，包括炎性疼痛，手术后切口疼痛，神经性疼痛，骨折疼痛，骨质疏松性骨折疼痛，疱疹后神经痛，骨关节炎，类风湿性关节炎，癌症疼痛，由灼伤引起的疼痛，痛风痛， 以及肝细胞癌，乳腺癌和肝硬化等疾病。

    HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR
    6.
    发明申请
    HIGH AFFINITY HUMAN ANTIBODIES TO HUMAN NERVE GROWTH FACTOR 有权
    人类神经生长因子的高亲和力人体抗体

    公开(公告)号：US20120164688A1

    公开(公告)日：2012-06-28

    申请号：US13406734

    申请日：2012-02-28

    申请人： Lynn MACDONALD ,  Richard Torres ,  Marc R. Morra ,  Joel H. Martin ,  Joel C. Reinhardt

    发明人： Lynn MACDONALD ,  Richard Torres ,  Marc R. Morra ,  Joel H. Martin ,  Joel C. Reinhardt

    IPC分类号： C12P21/02 ,  C12N5/10 ,  C12N1/21 ,  C12N15/13 ,  C12N15/63

    CPC分类号： C07K16/22 ,  A61K2039/505 ,  A61K2039/545 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

    摘要： A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with KD of 5 pM or less, as measured by surface plasmon resonance, wherein the antibody or fragment thereof binds human NGF with an affinity of about 2-10-fold higher than the antibody or fragment binds rat and mouse NGF. The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from burns, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.

    摘要翻译： 抗体的人抗体或抗原结合片段，其通过表面等离振子共振测定的KD为5pM以下的特异性结合人神经生长因子（NGF），其中所述抗体或其片段以大约的亲和力结合人NGF 抗体或片段的2-10倍高于大鼠和小鼠NGF。 抗体可用于治疗疼痛，包括炎性疼痛，手术后切口疼痛，神经性疼痛，骨折疼痛，骨质疏松性骨折疼痛，疱疹后神经痛，骨关节炎，类风湿性关节炎，癌症疼痛，由灼伤引起的疼痛，痛风痛， 以及肝细胞癌，乳腺癌和肝硬化等疾病。