公开(公告)号：US10730945B2

公开(公告)日：2020-08-04

申请号：US15861966

申请日：2018-01-04

申请人： MacroGenics, Inc.

发明人： Leslie S. Johnson ,  Ling Huang ,  Paul A. Moore ,  Deryk T. Loo ,  Francine Z. Chen

IPC分类号： A61K39/00 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28 ,  G01N33/574 ,  A61K47/68

摘要： The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.

公开(公告)号：US20150259434A1

公开(公告)日：2015-09-17

申请号：US14727135

申请日：2015-06-01

申请人： MACROGENICS, INC.

发明人： Leslie S. Johnson ,  Paul A. Moore ,  Ling Huang ,  Deryk T. Loo ,  Francine Z. Chen

IPC分类号： C07K16/30 ,  A61K45/06 ,  C07K16/28 ,  A61K39/395 ,  C07K16/46 ,  C07K16/44

CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2803 ,  C07K16/2827 ,  C07K16/2896 ,  C07K16/3076 ,  C07K16/3092 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/6893

摘要： The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.

公开(公告)号：US20200377612A1

公开(公告)日：2020-12-03

申请号：US16868927

申请日：2020-05-07

申请人： MacroGenics, Inc.

发明人： Leslie S. Johnson ,  Paul A. Moore ,  Ling Huang ,  Deryk T. Loo ,  Francine Zhifen Chen

IPC分类号： C07K16/30 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C07K16/44 ,  G01N33/68 ,  C07K16/46

摘要： The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.

公开(公告)号：US20170362333A1

公开(公告)日：2017-12-21

申请号：US15626709

申请日：2017-06-19

申请人： MacroGenics, Inc.

发明人： Leslie S. Johnson ,  Paul A. Moore ,  Ling Huang ,  Deryk T. Loo ,  Francine Zhifen Chen

IPC分类号： C07K16/30 ,  C07K16/28 ,  C07K16/44 ,  C07K16/46 ,  G01N33/68 ,  A61K45/06 ,  A61K39/00

摘要： The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.

公开(公告)号：US09714296B2

公开(公告)日：2017-07-25

申请号：US14727135

申请日：2015-06-01

申请人： MACROGENICS, INC.

发明人： Leslie S. Johnson ,  Paul A. Moore ,  Ling Huang ,  Deryk T. Loo ,  Francine Zhifen Chen

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K16/30 ,  A61K39/395 ,  C07K16/28 ,  A61K45/06 ,  C07K16/44 ,  G01N33/68 ,  C07K16/46

CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2803 ,  C07K16/2827 ,  C07K16/2896 ,  C07K16/3076 ,  C07K16/3092 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/6893

摘要： The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.

公开(公告)号：US09714295B2

公开(公告)日：2017-07-25

申请号：US14727032

申请日：2015-06-01

申请人： MACROGENICS, INC.

发明人： Leslie S. Johnson ,  Paul A. Moore ,  Ling Huang ,  Deryk T. Loo ,  Francine Zhifen Chen

IPC分类号： A61K38/00 ,  C07K16/30 ,  A61K39/395 ,  A61K39/00 ,  C07K16/28 ,  A61K45/06 ,  C07K16/44 ,  G01N33/68 ,  C07K16/46

CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2803 ,  C07K16/2827 ,  C07K16/2896 ,  C07K16/3076 ,  C07K16/3092 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/6893

摘要： The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.

公开(公告)号：US20240165256A1

公开(公告)日：2024-05-23

申请号：US18280896

申请日：2022-03-07

申请人： IMMUNOGEN, INC. ,  MACROGENICS, INC.

发明人： Eric Henry Westin ,  Callum Sloss ,  Krystal Marie Watkins ,  Deryk T. Loo ,  Juniper A. Scribner ,  Francine Zhifen Chen

IPC分类号： A61K47/68 ,  A61P35/00 ,  G01N33/574

CPC分类号： A61K47/6851 ,  A61K47/68033 ,  A61K47/6889 ,  A61P35/00 ,  G01N33/57484 ,  G01N2333/96486

摘要： The present disclosure provides methods of treating cancer in a subject who has an increased level of ADAM9 expression. The method comprises administering to the subject a therapeutically effective amount of an anti-ADAM9 immunoconjugate. Also provided is a method of increasing the efficacy of cancer treatment with an anti-ADAM9 immunoconjugate in a subject who has an increased level of ADAM9 expression.

公开(公告)号：US09441049B2

公开(公告)日：2016-09-13

申请号：US14331876

申请日：2014-07-15

申请人： MacroGenics, Inc.

发明人： Leslie S. Johnson ,  Ling Huang ,  Paul A. Moore ,  Deryk T. Loo ,  Francine Z. Chen

IPC分类号： A61K38/00 ,  C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  A61K47/48 ,  C07K16/28 ,  G01N33/574 ,  A61K39/00

CPC分类号： C07K16/2827 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6849 ,  A61K47/6851 ,  A61K47/6855 ,  A61K2039/505 ,  C07K16/2809 ,  C07K16/30 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/94 ,  G01N33/57484 ,  A61K2300/00

摘要： The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.

摘要翻译： 本发明涉及对哺乳动物，特别是人B7-H3受体及其用途，特别是治疗癌症和炎症的免疫反应性的抗体。 因此，本发明特别涉及能够介导，更优选增强针对与多种人类癌症相关的癌细胞的免疫系统的活化的人源化B7-H3-反应性抗体。

公开(公告)号：US20150274838A1

公开(公告)日：2015-10-01

申请号：US14727032

申请日：2015-06-01

申请人： MACROGENICS, INC.

发明人： Leslie S. Johnson ,  Paul A. Moore ,  Ling Huang ,  Deryk T. Loo ,  Francine Z. Chen

IPC分类号： C07K16/30 ,  A61K39/395 ,  A61K45/06 ,  C07K16/28

CPC分类号： C07K16/30 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2803 ,  C07K16/2827 ,  C07K16/2896 ,  C07K16/3076 ,  C07K16/3092 ,  C07K16/44 ,  C07K16/468 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  G01N33/6893

摘要： The present invention relates to antibodies and their fragments that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies and their immunoreactive fragments that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers.

摘要翻译： 本发明涉及对哺乳动物，特别是人B7-H3受体及其用途，特别是治疗癌症和炎症的免疫反应性的抗体及其片段。 因此，本发明特别涉及人源化的B7-H3-反应性抗体及其能够介导，更优选增强针对与多种人类癌症相关的癌细胞的免疫系统的活化的免疫反应性片段。

公开(公告)号：US11591400B2

公开(公告)日：2023-02-28

申请号：US17124972

申请日：2020-12-17

申请人： MacroGenics, Inc.

发明人： Deryk T. Loo ,  Ling Huang ,  Leslie S. Johnson ,  Thomas Son ,  Juniper A. Scribner ,  Ezio Bonvini

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61K39/395 ,  A61P35/00 ,  A61K39/00

摘要： The present invention is directed to novel B7-H3-binding molecules capable of binding to human and non-human B7-H3, and in particular to such molecules that are cross-reactive with B7-H3 of a non-human primate (e.g., a cynomolgus monkey). The invention additionally pertains to B7-H3-binding molecules that comprise Variable Light Chain and/or Variable Heavy Chain (VH) Domains that have been humanized and/or deimmunized so as to exhibit a reduced immunogenicity upon administration to recipient subjects. The invention particularly pertains to bispecific, trispecific or multispecific B7-H3-binding molecules, including bispecific diabodies, BiTEs, bispecific antibodies, trivalent binding molecules, etc. that comprise: (i) such B7-H3-binding Variable Domains and (ii) a domain capable of binding to an epitope of a molecule present on the surface of an effector cell. The invention is also directed to pharmaceutical compositions that contain any of such B7-H3-binding molecules, and to methods involving the use of any of such B7-H3-binding molecules in the treatment of cancer and other diseases and conditions. The invention also particularly pertains to a molecule that comprises the human B7-H3 binding domain of a humanized anti-human B7-H3 antibody conjugated to at least one drug moiety (a “B7-H3-ADC”). The invention is also directed to pharmaceutical compositions that contain such B7-H3-ADCs, and to methods involving the use of any of such B7-H3-ADCs in the treatment of cancer and other diseases and conditions.