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    Bi-Specific Monovalent Diabodies That are Capable of Binding to gpA33 and CD3, and Uses Thereof
    7.
    发明申请
    Bi-Specific Monovalent Diabodies That are Capable of Binding to gpA33 and CD3, and Uses Thereof 有权
    能够与gpA33和CD3结合的双特异性单价双体，及其用途

    公开(公告)号：US20160222105A1

    公开(公告)日：2016-08-04

    申请号：US14913654

    申请日：2014-08-20

    申请人： MACROGENICS, INC.

    发明人： Paul A. Moore ,  Jonathan Li ,  Francine Zhifen Chen ,  Leslie S. Johnson ,  Kalpana Shah ,  Ezio Bonvini

    IPC分类号： C07K16/28 ,  C07K16/30

    CPC分类号： C07K16/28 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/3046 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/56 ,  C07K2317/624 ,  C07K2317/626 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/31

    摘要： The present invention is directed to bi-specific monovalent diabodies that comprise two polypeptide chains and which possess at least one binding site specific for an epitope of CD3 and one binding site specific for an epitope of gpA33 (i.e., a “gpA33×CD3 bi-specific monovalent diabody”). The present invention also is directed to bi-specific monovalent diabodies that comprise an immunoglobulin Fc Domain (“bi-specific monovalent Fc diabodies”) and are composed of three polypeptide chains and which possess at least one binding site specific for an epitope of gpA33 and one binding site specific for an epitope of CD3 (i.e., a “gpA33×CD3 bi-specific monovalent Fc diabody”). The bi-specific monovalent diabodies and bi-specific monovalent Fc diabodies of the present invention are capable of simultaneous binding to gpA33 and CD3. The invention is directed to pharmaceutical compositions that contain such bi-specific monovalent diabodies or such bi-specific monovalent Fc diabodies. The invention is additionally directed to methods for the use of such diabodies in the treatment of cancer and other diseases and conditions.

    摘要翻译： 本发明涉及包含两条多肽链并具有至少一个特异于CD3表位的结合位点和一个特异于gpA33表位的结合位点（即，“gpA33×CD3双 - 特异性单价双抗体“）。 本发明还涉及包含免疫球蛋白Fc结构域（“双特异性单价Fc双抗体”）并由三条多肽链组成且具有至少一个对gpA33的表位具有特异性的结合位点的双特异性单抗双抗体， 一个特异于CD3表位的结合位点（即“gpA33×CD3双特异性单价Fc双抗体”）。 本发明的双特异性单价双抗体和双特异性单价Fc双抗体能够同时结合gpA33和CD3。 本发明涉及含有这种双特异性单价双抗体或这种双特异性单价Fc双抗体的药物组合物。 本发明另外涉及使用这种双抗体治疗癌症和其它疾病和病症的方法。

    Bi-specific monovalent diabodies that are capable of binding to gpA33 and CD3, and uses thereof
    8.
    发明授权
    Bi-specific monovalent diabodies that are capable of binding to gpA33 and CD3, and uses thereof 有权

    公开(公告)号：US10858430B2

    公开(公告)日：2020-12-08

    申请号：US15819423

    申请日：2017-11-21

    申请人： MacroGenics, Inc.

    发明人： Paul A. Moore ,  Jonathan Li ,  Francine Zhifen Chen ,  Leslie S. Johnson ,  Kalpana Shah ,  Ezio Bonvini

    IPC分类号： C07K16/28 ,  C07K16/30 ,  A61K39/00

    摘要： The present invention is directed to bi-specific monovalent diabodies that comprise two polypeptide chains and which possess at least one binding site specific for an epitope of CD3 and one binding site specific for an epitope of gpA33 (i.e., a “gpA33×CD3 bi-specific monovalent diabody”). The present invention also is directed to bi-specific monovalent diabodies that comprise an immunoglobulin Fc Domain (“bi-specific monovalent Fc diabodies”) and are composed of three polypeptide chains and which possess at least one binding site specific for an epitope of gpA33 and one binding site specific for an epitope of CD3 (i.e., a “gpA33×CD3 bi-specific monovalent Fc diabody”). The bi-specific monovalent diabodies and bi-specific monovalent Fc diabodies of the present invention are capable of simultaneous binding to gpA33 and CD3. The invention is directed to pharmaceutical compositions that contain such bi-specific monovalent diabodies or such bi-specific monovalent Fc diabodies. The invention is additionally directed to methods for the use of such diabodies in the treatment of cancer and other diseases and conditions.