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公开(公告)号：US09963415B2
公开(公告)日：2018-05-08
申请号：US15414058
申请日：2017-01-24
发明人： Sambandan Tg , Chokyun Rha , Ravigadevi Sambanthamurthi , Anthony J Sinskey , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohd Basri Wahid
CPC分类号： C07C51/50 , C07C51/42 , C07C51/48 , C07C2101/16 , C07C2601/16 , C12N9/1092 , C12Y205/01019 , C07C62/32
摘要： The present invention provides compositions and method for production of shikimic acid based on extracts obtained from oil palm-based materials, and more particularly oil palm based waste materials and by-products. The method includes purifying shikimic acid from extracts comprising oil palm phenolics (OPP).
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公开(公告)号：US09750782B2
公开(公告)日：2017-09-05
申请号：US14322564
申请日：2014-07-02
发明人： Mahinda Abeywardena , Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohd Basri Wahid
IPC分类号： A61K36/889 , A61K45/06 , A23L33/105
CPC分类号： A61K36/889 , A23L33/105 , A23V2002/00 , A61K45/06 , A23V2200/326 , A23V2250/21
摘要： The present invention relates to a composition for the use in improving vascular health, including treating and preventing vascular diseases and diseases related thereto, using a botanical extract of oil palm vegetation liquor from the palm oil milling process.
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公开(公告)号：US09962421B2
公开(公告)日：2018-05-08
申请号：US15621078
申请日：2017-06-13
发明人： T. G. Sambandan , ChoKyun Rha , Anthony J. Sinskey , Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohd Basri Wahid
IPC分类号： A61K36/889
CPC分类号： A61K36/889
摘要： A composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives. The method includes the steps of pre-concentrating an extract containing the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives and isolating said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives from said extract by liquid chromatography, wherein the elution activity of said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives vary depending on the stationary phase and the composition of the mobile phase.
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公开(公告)号：US09669065B2
公开(公告)日：2017-06-06
申请号：US14158606
申请日：2014-01-17
发明人： Nagendran Balasundram , Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram , Mohd Basri Wahid , Samir Samman , Nihal S. Agar
IPC分类号： A61K36/889
CPC分类号： A61K36/889
摘要： The invention provides a composition for the prevention and inhibition of oxidative stress and hemolysis in human red blood cell wherein said composition compounds obtained from the aqueous stream of palm oil milling (palm oil vegetation liquor), in particular from vegetative liquor from the milling of palm oil fruit.
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5.发明授权Botanical extracts from oil palm vegetation liquor for cosmeceutical applications 有权来自油棕植物油的植物提取物用于药妆用途公开(公告)号：US09381145B2
公开(公告)日：2016-07-05
申请号：US14513068
申请日：2014-10-13
CPC分类号： A61K8/368 , A61K8/97 , A61K36/00 , A61K36/889 , A61K2800/10 , A61K2800/522 , A61K2800/92 , A61Q1/12 , A61Q5/00 , A61Q19/08 , A61Q19/10
摘要： A cosmeceutical composition comprising phenolic compounds, fruit acids and sugars, extracted from the vegetation liquor of the palm oil milling process has been suggested. This composition is rich in antioxidants, and significantly improves skin health, including preventing aging of skin.
摘要翻译： 已经提出了从棕榈油研磨过程的植物液中提取的包含酚类化合物，果酸和糖的药妆组合物。 该组合物具有丰富的抗氧化剂，并显着改善皮肤健康，包括防止皮肤老化。
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公开(公告)号：US20140314875A1
公开(公告)日：2014-10-23
申请号：US14322564
申请日：2014-07-02
申请人： Malaysian Palm Oil Board , Commonwealth Scientific and Industrial Research Organisation (CSIRO)
发明人： Mahinda Abeywardena , Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohd Basri Wahid
IPC分类号： A61K36/889 , A23L1/30 , A61K45/06
CPC分类号： A61K36/889 , A23L33/105 , A23V2002/00 , A61K45/06 , A23V2200/326 , A23V2250/21
摘要： The present invention relates to a composition for the use in improving vascular health, including treating and preventing vascular diseases and diseases related thereto, using a botanical extract of oil palm vegetation liquor from the palm oil milling process.
摘要翻译： 本发明涉及一种用于改善血管健康的组合物，包括使用来自棕榈油研磨过程的油棕榈植物液的植物提取物来治疗和预防与之相关的血管疾病和疾病。
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7.发明申请COMPOUNDS EXTRACTED FROM PALM OIL MILL EFFLUENT FOR THE TREATMENT OF CANCER, COMPOSITIONS THEREOF AND METHODS THEREWITH 审中-公开从棕榈油提取的化合物用于治疗癌症的组合物及其组合物及其方法公开(公告)号：US20150196614A1
公开(公告)日：2015-07-16
申请号：US14564014
申请日：2014-12-08
发明人： Kalyana Sundram P. MANICKAM , Ravigadevi Sambathamurthi , Yew Ai Tan , Mohd Basri Wahid , Soon Sen Leow
IPC分类号： A61K36/889 , A61K31/355 , A23L1/30 , A61K45/06
CPC分类号： A61K36/889 , A23L33/105 , A23V2002/00 , A61K31/355 , A61K31/704 , A61K45/06
摘要： The present invention describes a composition and methods for prevention and treatment of cancer comprising compounds extracted from Palm oil mill effluent. Also, the invention describes effective therapeutic dosages of the compounds and their combinations. The present invention can be prepared independently or as a combination product.
摘要翻译： 本发明描述了一种用于预防和治疗癌症的组合物和方法，其包括从棕榈油磨出料中提取的化合物。 此外，本发明描述了化合物及其组合的有效治疗剂量。 本发明可以单独制备或作为组合产品制备。
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公开(公告)号：US10603348B2
公开(公告)日：2020-03-31
申请号：US15944616
申请日：2018-04-03
发明人： T.G. Sambandan , ChoKyun Rha , Anthony J. Sinskey , Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohd Basri Wahid
IPC分类号： A61K36/889
摘要： A composition comprising caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives extracted from any part of oil palm including but not confined to the vegetation liquor of palm oil milling and palm oil mill effluent, and a method for use in the preparation of a composition containing caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives. The method includes the steps of pre-concentrating an extract containing the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, caffeoylshikimic acids and their derivatives and isolating the caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, said caffeoylshikimic acids and their derivatives from said extract by liquid chromatography, wherein the elution activity of said caffeoylshikimic acids, protocatechuic acid, hydroxytyrosol, hydroxybenzoic acid, with the caffeoylshikimic acids and their derivatives varying depending on the stationary phase and the composition of the mobile phase.
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公开(公告)号：US10308583B2
公开(公告)日：2019-06-04
申请号：US15943777
申请日：2018-04-03
发明人： Sambandan Tg , Chokyun Rha , Ravigadevi Sambanthamurthi , Anthony J. Sinskey , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohd Basri Wahid
摘要： The present invention provides compositions and method for production of shikimic acid based on extracts obtained from oil palm-based materials, and more particularly oil palm-based waste materials and by-products. The method includes purifying shikimic acid from extracts comprising oil palm phenolics (OPP).
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公开(公告)号：US09931368B2
公开(公告)日：2018-04-03
申请号：US14531731
申请日：2014-11-03
发明人： Soon Sen Leow , Ravigadevi Sambanthamurthi , Yew Ai Tan , Kalyana Sundram P. Manickam , Mohd Basri Wahid
IPC分类号： A61K36/889 , A61K31/05
CPC分类号： A61K36/889 , A61K31/05
摘要： A composition comprising extracts containing oil palm phenolics in an amount effective for use in a method of reducing cholesterol biosynthesis and thus preventing obesity. The composition up regulates fatty acid beta oxidation and down regulates cholesterol biosynthesis in livers. The composition is useful for prevention of obesity associated diseases. The composition delays the onset of obesity and attenuates the inflammatory response of atherogenic diet, whereby the composition aids to suppress the inflammatory response thereby ameliorating artherosclerosis. The composition delays weight gain or obesity thereby preventing the effects of dyslipidemia.
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