公开(公告)号：US11085916B2

公开(公告)日：2021-08-10

申请号：US16085755

申请日：2017-07-18

Applicant: MANDOM CORPORATION ,  OSAKA UNIVERSITY

Inventor： Kie Nakashima ,  Ryuichiro Kurata ,  Fumitaka Fujita ,  Kiyotoshi Sekiguchi ,  Atsushi Tanemura ,  Hiroyuki Murota ,  Ichiro Katayama

IPC: G01N33/50 ,  A61B5/00 ,  A61K38/18

Abstract: A method for observing the dynamics of sweat glands and a method for evaluating a substance of interest, which are useful for development of a preparation for external application, such as a cosmetic. In each of the methods, an observation sample is used, which is prepared by staining all sweat glands, which are isolated alive, with a staining reagent, and then holding the all sweat glands on a support using at least one material selected from the group consisting of collagen, agarose, basement membrane matrix, poly-D-lysine and a membrane.

公开(公告)号：US20210361549A1

公开(公告)日：2021-11-25

申请号：US16641775

申请日：2019-03-18

Applicant: MANDOM CORPORATION ,  OSAKA UNIVERSITY

Inventor： Kie Nakashima ,  Ryuichiro Kurata ,  Fumitaka Fujita ,  Fumihiro Okada

IPC: A61K8/365 ,  A61K8/37 ,  A61K8/60 ,  A61Q15/00

Abstract: Provided is an antiperspirant which serves to control secretion of sweat secreted from sweat glands and is capable of doing so by acting on sweat glands without closing sweat pores, the antiperspirant containing, as an active ingredient to control secretion of sweat secreted from sweat glands, at least one type of pentacyclic compound selected from the group consisting of compounds represented by formula (I): and derivatives thereof, and compounds represented by formula (VII): and derivatives thereof.

公开(公告)号：US20190049429A1

公开(公告)日：2019-02-14

申请号：US16085755

申请日：2017-07-18

Applicant: MANDOM CORPORATION ,  OSAKA UNIVERSITY

Inventor： Kie Nakashima ,  Ryuichiro Kurata ,  Fumitaka Fujita ,  Kiyotoshi Sekiguchi ,  Atsushi Tanemura ,  Hiroyuki Murota ,  Ichiro Katayama

IPC: G01N33/50 ,  A61B5/00

Abstract: A method for observing the dynamics of sweat glands and a method for evaluating a substance of interest, which are useful for development of a preparation for external application, such as a cosmetic. In each of the methods, an observation sample is used, which is prepared by staining all sweat glands, which are isolated alive, with a staining reagent, and then holding the all sweat glands on a support using at least one material selected from the group consisting of collagen, agarose, basement membrane matrix, poly-D-lysine and a membrane.