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公开(公告)号：US12097292B2
公开(公告)日：2024-09-24
申请号：US17902030
申请日：2022-09-02
申请人： MAPI PHARMA LTD.
发明人： Nadav Bleich Kimelman , Shai Rubnov , Ehud Marom
CPC分类号： A61K9/5094 , A61K9/0019 , A61K9/19 , A61K9/5031
摘要： The present invention provides an improved process for preparing microparticles containing glatiramer acetate having low levels of residual organic solvent(s), in particular dichloromethane. The microparticles are incorporated into long acting parenteral pharmaceutical compositions in depot form that are suitable for subcutaneous or intramuscular implantation or injection, and that may be used to treat multiple sclerosis.
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公开(公告)号：US09617241B2
公开(公告)日：2017-04-11
申请号：US14890354
申请日：2015-03-02
申请人： MAPI PHARMA LTD.
发明人： Anna Gopin , Shai Rubnov , Galina Zats , Ehud Marom
IPC分类号： C07D401/06 , C07C25/24 , C07C31/40 , C07C29/40 , C07C17/35
摘要： The present invention relates to a process for the preparation of (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylene-1-piperidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (Efinaconazole) and intermediates used in such process.
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公开(公告)号：USRE49251E1
公开(公告)日：2022-10-18
申请号：US17213352
申请日：2021-03-26
申请人： MAPI PHARMA LTD.
发明人： Ehud Marom , Shai Rubnov
摘要： Long acting parenteral pharmaceutical compositions comprising a therapeutically effective amount of glatiramer are provided. In particular, the present invention provides a long acting pharmaceutical composition comprising a therapeutically effective amount of glatiramer acetate in depot form suitable for administering at a medically acceptable location in a subject in need thereof. The depot form is suitable for subcutaneous or intramuscular implantation or injection.
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公开(公告)号：US11167003B2
公开(公告)日：2021-11-09
申请号：US16497120
申请日：2018-03-25
申请人： MAPI PHARMA LTD.
发明人： Uri Danon , Nadav Bleich Kimelman , Laura Popper , Ehud Marom
IPC分类号： A61K38/00 , A61P25/00 , A61P25/28 , A61K38/02 , A61K9/00 , A61K47/34 , A61K38/10 , A61K38/16 , A61K39/00 , C07K14/47
摘要： The present invention provides methods for treating or ameliorating primary progressive multiple sclerosis (PPMS) or secondary progressive multiple sclerosis (SPMS) and related symptoms by administering or implanting a depot formulation comprising glatiramer salts, such as glatiramer acetate (GA).
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公开(公告)号：US09200114B2
公开(公告)日：2015-12-01
申请号：US13764460
申请日：2013-02-11
申请人： MAPI PHARMA LTD.
发明人： Ehud Marom , Shai Rubnov
CPC分类号： C08G69/10 , A61K31/785 , A61K38/00 , A61K45/06 , C07K14/001 , A61K2300/00
摘要： The present invention relates to a synthetic polypeptide which is a random linear pentapolymer comprising alanine, glutamic acid, lysine, tyrosine and phenylalanine and use thereof in treating autoimmune diseases, in particular multiple sclerosis.
摘要翻译： 本发明涉及合成多肽，其是包含丙氨酸，谷氨酸，赖氨酸，酪氨酸和苯丙氨酸的无规线性五元共聚物及其在治疗自身免疫性疾病，特别是多发性硬化中的用途。
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6.发明授权公开(公告)号：US11413311B2
公开(公告)日：2022-08-16
申请号：US16613355
申请日：2017-05-15
摘要： Methods of treating multiple sclerosis are provided, comprising parenterally administering glatiramer acetate in a sustained-release depot form, and administering adipose-derived stem cells into the central nervous system. According to some aspects the combined treatments provide synergistic effects. In particular the combined therapies offer benefits to progressive forms of multiple sclerosis.
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公开(公告)号：US10111867B2
公开(公告)日：2018-10-30
申请号：US15543363
申请日：2015-02-17
申请人： MAPI PHARMA LTD.
发明人： Ehud Marom , Shai Rubnov
IPC分类号： A61K31/444 , C07D213/64 , C07D401/04
摘要： The present invention describes a process for the synthesis of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-di-hydro-pyridin-2-one (Perampanel) represented by the structure of formula (1), and salts thereof, especially salts with pharmaceutically acceptable acids. The present invention further relates to certain intermediates formed and/or used in such process.
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公开(公告)号：US09453024B2
公开(公告)日：2016-09-27
申请号：US14551497
申请日：2014-11-24
申请人： MAPI PHARMA LTD.
发明人： Ehud Marom
IPC分类号： C07D493/04 , A61K9/20 , A61K31/427 , A61K45/06 , A61K31/34
CPC分类号： C07D493/04 , A61K9/20 , A61K31/34 , A61K31/427 , A61K45/06 , C07B2200/13 , Y10T428/2982 , A61K2300/00
摘要： The present invention provides new pseudopolymorphic forms of darunavir as well as a novel amorphous form of darunavir, pharmaceutical compositions comprising these compounds, methods for their preparation and use thereof in treating retroviral infections, in particular, HIV infection.
摘要翻译： 本发明提供了地瑞那韦的新的假多晶型形式以及达瑞那韦的新型无定形形式，包含这些化合物的药物组合物，其制备方法和用于治疗逆转录病毒感染，特别是HIV感染。
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公开(公告)号：US11865213B2
公开(公告)日：2024-01-09
申请号：US17534533
申请日：2021-11-24
申请人： Mapi Pharma Ltd.
发明人： Galina Zats , Nadav Bleich Kimelman , Shai Rubnov , Ehud Marom
CPC分类号： A61K9/1647 , A61K9/1611 , A61K9/1635 , A61K9/1682 , A61K38/26 , A61P3/04 , A61P3/10
摘要： The present invention provides parenteral pharmaceutical compositions comprising therapeutically effective amounts of semaglutide or pharmaceutically acceptable salts thereof, the parenteral pharmaceutical compositions are formulated in depot form and provide low-burst release and a continued release profile. The present invention further provides methods of use of the parenteral pharmaceutical compositions for treating type-2 diabetes mellitus, obesity, and Parkinson's disease.
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公开(公告)号：US11471421B2
公开(公告)日：2022-10-18
申请号：US16328572
申请日：2017-08-28
申请人： MAPI PHARMA LTD.
发明人： Nadav Bleich Kimelman , Shai Rubnov , Ehud Marom
摘要： The present invention provides an improved process for preparing microparticles containing glatiramer acetate having low levels of residual organic solvent(s), in particular dichloromethane. The microparticles are incorporated into long acting parenteral pharmaceutical compositions in depot form that are suitable for subcutaneous or intramuscular implantation or injection, and that may be used to treat multiple sclerosis.
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