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公开(公告)号：US09617241B2
公开(公告)日：2017-04-11
申请号：US14890354
申请日：2015-03-02
申请人： MAPI PHARMA LTD.
发明人： Anna Gopin , Shai Rubnov , Galina Zats , Ehud Marom
IPC分类号： C07D401/06 , C07C25/24 , C07C31/40 , C07C29/40 , C07C17/35
摘要： The present invention relates to a process for the preparation of (2R,3R)-2-(2,4-difluorophenyl)-3-(4-methylene-1-piperidinyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol (Efinaconazole) and intermediates used in such process.
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公开(公告)号：US07041848B2
公开(公告)日：2006-05-09
申请号：US10221108
申请日：2001-03-07
申请人： Eric Fache
发明人： Eric Fache
CPC分类号： C07C51/313 , C07B41/00 , C07C27/12 , C07C29/50 , C07C45/33 , C07C45/36 , C07C51/215 , C07C2601/14 , C07C2601/20 , C07C49/403 , C07C55/14 , C07C55/21 , C07C35/08 , C07C35/205 , C07C31/38 , C07C31/40
摘要： The present invention relates to a process for oxidizing hydrocarbons, in particular branched or unbranched saturated aliphatic hydrocarbons, cycloaliphatic or alkylaromatic hydrocarbons to acidic or polyacidic compounds.The invention relates more particularly to the oxidation, with an oxidizing agent containing molecular oxygen, of cyclohexane to adipic acid, in the presence of organic acid of lipophilic nature and in the absence of adipic acid. The separation and recycling of the unoxidized cyclohexane, the oxidation intermediates and the catalysts are easier than in the presence of acetic acid.
摘要翻译： 本发明涉及一种将烃类特别是支链或非支链饱和脂族烃，脂环族或烷基芳族烃氧化成酸性或多元酸化合物的方法。 本发明更具体地涉及在亲脂性的有机酸和不存在己二酸的情况下，使用含有分子氧的氧化剂的环己烷与己二酸的氧化。 未氧化的环己烷，氧化中间体和催化剂的分离和再循环比在乙酸存在下更容易。
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公开(公告)号：US20030166967A1
公开(公告)日：2003-09-04
申请号：US10221108
申请日：2002-12-02
发明人： Eric Fache
IPC分类号： C07C051/16 , C07C051/255 , C07C051/31
CPC分类号： C07C51/313 , C07B41/00 , C07C27/12 , C07C29/50 , C07C45/33 , C07C45/36 , C07C51/215 , C07C2601/14 , C07C2601/20 , C07C49/403 , C07C55/14 , C07C55/21 , C07C35/08 , C07C35/205 , C07C31/38 , C07C31/40
摘要： The present invention relates to a process for oxidizing hydrocarbons, in particular branched or unbranched saturated aliphatic hydrocarbons, cycloaliphatic or alkylaromatic hydrocarbons to acidic or polyacidic compounds. The invention relates more particularly to the oxidation, with an oxidizing agent containing molecular oxygen, of cyclohexane to adipic acid, in the presence of organic acid of lipophilic nature and in the absence of adipic acid. The separation and recycling of the unoxidized cyclohexane, the oxidation intermediates and the catalysts are easier than in the presence of acetic acid.
摘要翻译： 本发明涉及一种将烃类特别是支链或非支链饱和脂族烃，脂环族或烷基芳族烃氧化成酸性或多元酸化合物的方法。 本发明更具体地涉及在亲脂性的有机酸和不存在己二酸的情况下，使用含有分子氧的氧化剂的环己烷与己二酸的氧化。 未氧化的环己烷，氧化中间体和催化剂的分离和再循环比在乙酸存在下更容易。
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公开(公告)号：US5571870A
公开(公告)日：1996-11-05
申请号：US240225
申请日：1994-05-10
IPC分类号： C07B39/00 , C07C17/02 , C07C17/06 , C07C17/12 , C07C31/40 , C07C41/22 , C07C41/48 , C07C43/12 , C07C43/313 , C07C43/315 , C07C43/32 , C07C45/54 , C07C49/167 , C07C67/307 , C07C209/74 , C07C211/15 , C08G65/00 , C08G65/323 , C08G65/337 , C07C17/04 , C07C19/00
CPC分类号： C08G65/337 , C07B39/00 , C07C17/02 , C07C17/06 , C07C17/12 , C07C209/74 , C07C211/15 , C07C31/40 , C07C41/22 , C07C41/48 , C07C41/60 , C07C45/54 , C07C49/167 , C07C67/307 , C08G65/00 , C08G65/007 , C08G65/3236 , C07C2101/14 , C07C2103/26
摘要： This invention pertains to a method for liquid phase fluorination for perfluorination of a wide variety of hydrogen-containing compounds.
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公开(公告)号：US5202506A
公开(公告)日：1993-04-13
申请号：US864819
申请日：1992-04-02
申请人： Jack R. Kirchner , Leonard H. Beck , James E. Dowd
发明人： Jack R. Kirchner , Leonard H. Beck , James E. Dowd
IPC分类号： C07C29/09 , C07C29/124 , C07C31/38 , C07C31/40
CPC分类号： C07C29/124 , C07C31/40
摘要： A process for the formation of perfluoroalkylethyl alcohols from perfluoroalkylethyl iodides is disclosed. The process involves treatment of the perfluoroalkylethyl iodide with oleum.
摘要翻译： 公开了一种从全氟烷基乙基碘化物形成全氟烷基乙醇的方法。 该方法包括用发烟硫酸处理全氟烷基乙基碘。
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公开(公告)号：US5185477A
公开(公告)日：1993-02-09
申请号：US803441
申请日：1991-12-06
申请人： Carl G. Krespan
发明人： Carl G. Krespan
IPC分类号： C07C31/40 , C07C303/24 , C07C305/08 , C07C305/26 , C07D303/08
CPC分类号： C07D303/08 , C07C31/40
摘要： Novel fluorinated (poly)sulfates, halosulfonates, halohydrins and epoxides, as well as novel processes for producing them are disclosed.
摘要翻译： 公开了新型氟化（多）硫酸盐，卤代磺酸盐，卤代醇和环氧化物，以及其制备方法。
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公开(公告)号：US5023377A
公开(公告)日：1991-06-11
申请号：US387819
申请日：1989-08-01
IPC分类号： C07C43/12 , C07B39/00 , C07B61/00 , C07C17/08 , C07C19/08 , C07C19/10 , C07C29/64 , C07C31/40 , C07C209/62 , C07C211/15 , C07C239/10 , C07C239/20 , C07C313/12 , C07C313/20 , C07C323/03
CPC分类号： C07B39/00 , C07C239/20 , C07C31/40
摘要： A process for preparing fluorinated compounds belonging to the classes:XH--Y--CZ.sub.1 Z.sub.2 -(CF.sub.2).sub.n F (I)andYH--X--(CF.sub.2).sub.n --CZ.sub.1 Z.sub.2 F (II)wherein:X is NR.sub.x, O, S, CFR.sub.x, C(R.sub.x).sub.2, or CF.sub.2 ;Y is NR.sub.x, O, S, CFR.sub.x, C(R.sub.x).sub.2, or CF.sub.2 ;X is different from Y;R.sub.x is a perhalogenated alkyl group, containing from 1 to 4 carbon atoms;n is either 0 or 1;Z.sub.1 and Z.sub.2, which may be either equal to, or different from, each other, represent F, Cl, Br, H or R.sub.x.The process is characterized in that a fluorinated cyclic compound of the formula: ##STR1## is reacted, at a temperature within the range of from -80.degree. to +300.degree., with HF in the presence of a Lewis acid. Some of the so-obtained compounds per se are novel.
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8.发明授权Process for the preparation of 1,1,2,2-tetrahydroperfluoroalkanols and their esters 失效制备1,1,2,2-四氢全氟烷醇及其酯的方法
公开(公告)号：US4791223A
公开(公告)日：1988-12-13
申请号：US128825
申请日：1987-12-04
申请人： Andre Lantz , Pascal Michaud
发明人： Andre Lantz , Pascal Michaud
IPC分类号： C07C67/03 , C07C27/00 , C07C29/124 , C07C29/48 , C07C31/38 , C07C31/40 , C07C67/00 , C07C69/63 , C07C67/02
CPC分类号： C07C31/40 , C07C29/124 , C07C67/11
摘要： The invention relates to the synthesis of 1,1,2,2-tetrahydroperfluoroalkanols and their esters by oxidizing a 2-(perfluoroalkyl)ethyl iodide using hydrogen peroxide in a carboxylic acid or carboxylic acid ester in the presence of sulphuric acid.In the process according to the invention, from 1 to 30 moles of sulphuric acid, from 1 to 50 moles of carboxylic acid or of an ester of such an acid, and from 3 to 20 moles of hydrogen peroxide per mole of 2-perfluoralkyl)ethyl iodide are used.
摘要翻译： 本发明涉及通过在硫酸存在下使用过氧化氢在羧酸或羧酸酯中氧化2-（全氟烷基）乙基碘来合成1,1,2,2-四氢全氟烷醇及其酯。 在根据本发明的方法中，每摩尔2-全氟烷基含有1至30摩尔硫酸，1至50摩尔羧酸或这种酸的酯和3至20摩尔过氧化氢， 使用乙基碘。
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公开(公告)号：US4544772A
公开(公告)日：1985-10-01
申请号：US604536
申请日：1984-04-27
摘要： Crude hexafluoroacetone (HFA) hydrate containing chlorofluoroacetone(s) hydrate(s) as impurity is purified by adding an alkali metal hydroxide and maintaining at an elevated temperature, preferably at 100.degree.-110.degree. C., to thereby cause decomposition reaction of every chlorofluoroacetone hydrate with the alkali metal hydroxide, followed by neutralization of an excess portion of the alkali metal hydroxide. Alkali metal hydroxides, which readily react with anhydrous HFA, react preferentially with chlorofluoroacetone hydrates but hardly react with coexisting HFA hydrate.
摘要翻译： 含有氯氟丙酮（水合物）杂质的粗六水丙酮（HFA）水合物通过加入碱金属氢氧化物并保持在升高的温度，优选在100-110℃下纯化，从而引起每个氯氟丙酮的分解反应 与碱金属氢氧化物水合，然后中和过量的碱金属氢氧化物。 容易与无水HFA反应的碱金属氢氧化物优先与氯氟丙酮水合物反应，但几乎不与共存的HFA水合物反应。
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公开(公告)号：US3758538A
公开(公告)日：1973-09-11
申请号：US3758538D
申请日：1968-09-03
申请人： ALLIED CHEM
CPC分类号： C07C31/40 , C07C29/68 , C07C31/34 , C07C51/15 , C07C59/135
摘要： This invention relates to novel salts which are prepared by the reaction of a fluorine-containing perhalogenated ketone with a compound selected from the group consisting of potassium fluoride, silver fluoride, cesium fluoride, rubidium fluoride and tetraalkylammonium fluoride. These salts are useful for the preparation of fluorinated ethers which can be employed in the preparation of surfactants.
摘要翻译： 本发明涉及通过含氟全卤代酮与选自氟化钾，氟化银，氟化铯，氟化铷和四烷基氟化铵的化合物的反应制备的新型盐。 这些盐可用于制备可用于制备表面活性剂的氟化醚。
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