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公开(公告)号：US20180244758A1
公开(公告)日：2018-08-30
申请号：US15898524
申请日：2018-02-17
发明人： Zachary A. Bornholdt , Larry Zeitlin , Kartik Chandran , Anna Wec , Laura Walker
CPC分类号： C07K16/10 , A61K39/42 , A61K2039/505 , A61K2039/545 , A61K2039/55 , A61K2039/57 , A61K2039/6075 , A61K2039/62 , A61P31/14 , C07K2317/76
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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公开(公告)号：US20200299363A1
公开(公告)日：2020-09-24
申请号：US16897027
申请日：2020-06-09
发明人： Zachary A. Bornholdt , Larry Zeitlin , Kartik Chandran , Anna Wec , Laura Walker
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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公开(公告)号：US20200299362A1
公开(公告)日：2020-09-24
申请号：US16897013
申请日：2020-06-09
发明人： Zachary A. Bornholdt , Larry Zeitlin , Kartik Chandran , Anna Wec , Laura Walker
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially, similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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公开(公告)号：US20200299361A1
公开(公告)日：2020-09-24
申请号：US16897001
申请日：2020-06-09
发明人： Zachary A. Bornholdt , Larry Zeitlin , Kartik Chandran , Anna Wec , Laura Walker
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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公开(公告)号：US11242378B2
公开(公告)日：2022-02-08
申请号：US16896980
申请日：2020-06-09
发明人： Zachary A. Bornholdt , Larry Zeitlin , Kartik Chandran , Anna Wec , Laura Walker
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially, similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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公开(公告)号：US11242379B2
公开(公告)日：2022-02-08
申请号：US16896991
申请日：2020-06-09
发明人： Zachary A. Bornholdt , Larry Zeitlin , Kartik Chandran , Anna Wec , Laura Walker
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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公开(公告)号：US11407817B2
公开(公告)日：2022-08-09
申请号：US16897027
申请日：2020-06-09
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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8.发明申请公开(公告)号：US20210355195A1
公开(公告)日：2021-11-18
申请号：US17308753
申请日：2021-05-05
申请人： Albert Einstein College of Medicine , Adimab, LLC , Mapp Biopharmaceutical, Inc. , The University of Texas at Austin
发明人： Zachary A. Bornholdt , Akaash Mishra , Laura M. Walker , Noel T. Pauli , Daniel Maurer , Kartik Chandran , Jens Maximilian Fels , Dafna Abelson , Jason Scott McLellan , Jonathan R. Lai , Ariel Wirchnianski , Olivia Vergnolle
摘要： Anti-CCHFV antibodies with neutralizing potency and protective efficacy against CCHFV are provided, as well as methods for their identification, isolation, generation, and methods for their preparation and use are provided.
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公开(公告)号：US20230044044A1
公开(公告)日：2023-02-09
申请号：US17856774
申请日：2022-07-01
发明人： Zachary A. Bornholdt , Larry Zeitlin , Kartik Chandran , Anna Wec , Laura Walker
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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10.发明申请公开(公告)号：US20230000979A1
公开(公告)日：2023-01-05
申请号：US17829164
申请日：2022-05-31
申请人： Albert Einstein College of Medicine , Adimab, LLC , Mapp Biopharmaceutical, Inc. , Board of Regents, The University of Texas System , The Government of the United States, as represented by the Secretary of the Army
发明人： Zachary A. Bornholdt , Akaash Mishra , Laura M. Walker , Noel T. Pauli , Daniel Maurer , Kartik Chandran , Jens Maximilian Fels , Dafna Abelson , Jason Scott McLellan , Jonathan R. Lai , Ariel Wirchnianski , Olivia Vergnolle , John M. Dye , Andrew S. Herbert
摘要： Anti-CCHFV antibodies with neutralizing potency and protective efficacy against CCHFV are provided, as well as methods for their identification, isolation, generation, and methods for their preparation and use are provided.
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