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公开(公告)号：US20180244758A1
公开(公告)日：2018-08-30
申请号：US15898524
申请日：2018-02-17
发明人： Zachary A. Bornholdt , Larry Zeitlin , Kartik Chandran , Anna Wec , Laura Walker
CPC分类号： C07K16/10 , A61K39/42 , A61K2039/505 , A61K2039/545 , A61K2039/55 , A61K2039/57 , A61K2039/6075 , A61K2039/62 , A61P31/14 , C07K2317/76
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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2.发明申请MONOCLONAL ANTIBODIES WITH ALTERED AFFINITIES FOR HUMAN FCyRI, FCyRIIIa, AND C1q PROTEINS 审中-公开具有人类FCyRI，FCyRIIIa和C1q蛋白的改变活性的单克隆抗体公开(公告)号：US20130149300A1
公开(公告)日：2013-06-13
申请号：US13628439
申请日：2012-09-27
发明人： Andrew Hiatt , Larry Zeitlin
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/08 , C07K16/10 , C07K16/1018 , C07K16/24 , C07K16/2803 , C07K16/2887 , C07K16/32 , C07K2317/10 , C07K2317/13 , C07K2317/41 , C07K2317/71 , C07K2317/92
摘要： Disclosed herein are GNGN and G1/G2 antibodies that recognize and bind various FcRs and C1q. Also disclosed herein are glycan-optiminzed antibodies, predominantly of the GNGN or G1/G2 glycoform, with enhanced Fcγ receptor binding achieved through CHO, Nicotiana benthamiana and yeast manufacturing systems. Nucleic acids encoding these antibodies, as well as expression vectors and host cells including these nucleic acids are also disclosed herein. Methods and pharmaceutical compositions including the monoclonal antibodies are provided herein for the prevention and/or therapeutic treatment of viral infections, cancers and inflammatory diseases.
摘要翻译： 本文公开了识别并结合各种FcR和C1q的GNGN和G1 / G2抗体。 本文还公开了主要是GNGN或G1 / G2糖型的聚糖优化的抗体，其具有通过CHO，烟草和酵母制造系统实现的增强的Fcγ受体结合。 编码这些抗体的核酸以及包括这些核酸的表达载体和宿主细胞也在本文中公开。 本文提供包括单克隆抗体的方法和药物组合物用于预防和/或治疗病毒感染，癌症和炎性疾病。
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公开(公告)号：US20240228597A1
公开(公告)日：2024-07-11
申请号：US18337918
申请日：2023-06-20
发明人： Laura M. Walker
IPC分类号： C07K16/10
CPC分类号： C07K16/1027 , C07K2317/21 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Provided are antibodies or antigen binding polypeptides characterized by the ability to neutralize respiratory syncytial virus (RSV). Specifically, the antibodies or antigen binding polypeptides are characterized by high affinity binding to RSV fusion glycoprotein (RSVF). Further provided are methods for their identification, isolation, generation, preparation, and use, as well as the heavy chain and light chain sequences of the antibodies provided.
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公开(公告)号：US11242378B2
公开(公告)日：2022-02-08
申请号：US16896980
申请日：2020-06-09
发明人： Zachary A. Bornholdt , Larry Zeitlin , Kartik Chandran , Anna Wec , Laura Walker
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially, similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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公开(公告)号：US20200299363A1
公开(公告)日：2020-09-24
申请号：US16897027
申请日：2020-06-09
发明人： Zachary A. Bornholdt , Larry Zeitlin , Kartik Chandran , Anna Wec , Laura Walker
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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公开(公告)号：US20230044044A1
公开(公告)日：2023-02-09
申请号：US17856774
申请日：2022-07-01
发明人： Zachary A. Bornholdt , Larry Zeitlin , Kartik Chandran , Anna Wec , Laura Walker
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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7.发明申请公开(公告)号：US20230000979A1
公开(公告)日：2023-01-05
申请号：US17829164
申请日：2022-05-31
申请人： Albert Einstein College of Medicine , Adimab, LLC , Mapp Biopharmaceutical, Inc. , Board of Regents, The University of Texas System , The Government of the United States, as represented by the Secretary of the Army
发明人： Zachary A. Bornholdt , Akaash Mishra , Laura M. Walker , Noel T. Pauli , Daniel Maurer , Kartik Chandran , Jens Maximilian Fels , Dafna Abelson , Jason Scott McLellan , Jonathan R. Lai , Ariel Wirchnianski , Olivia Vergnolle , John M. Dye , Andrew S. Herbert
摘要： Anti-CCHFV antibodies with neutralizing potency and protective efficacy against CCHFV are provided, as well as methods for their identification, isolation, generation, and methods for their preparation and use are provided.
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公开(公告)号：US11407816B2
公开(公告)日：2022-08-09
申请号：US16897013
申请日：2020-06-09
发明人： Zachary A. Bornholdt , Larry Zeitlin , Kartik Chandran , Anna Wec , Laura Walker
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially, similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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公开(公告)号：US11254732B2
公开(公告)日：2022-02-22
申请号：US16897001
申请日：2020-06-09
发明人： Zachary A. Bornholdt , Larry Zeitlin , Kartik Chandran , Anna Wec , Laura Walker
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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公开(公告)号：US20200299361A1
公开(公告)日：2020-09-24
申请号：US16897001
申请日：2020-06-09
发明人： Zachary A. Bornholdt , Larry Zeitlin , Kartik Chandran , Anna Wec , Laura Walker
摘要： Described herein are compositions and methods for the prevention and treatment of ebolavirus infection. In certain embodiments of the present invention, monoclonal antibodies substantially similar to those described herein, as well as affinity matured variants thereof, alone or in combination, provide therapeutic efficacy in a patient against multiple species of ebolavirus.
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