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公开(公告)号：US20110097464A1
公开(公告)日：2011-04-28
申请号：US12909120
申请日：2010-10-21
申请人： MARIA HOLM , OLA LIND , JAMES VAN ALSTINE
发明人： MARIA HOLM , OLA LIND , JAMES VAN ALSTINE
CPC分类号： A23L2/80 , A23L2/74 , C12H1/0424
摘要： The present invention relates to liquid clarification and stabilization. More closely, the invention relates to both clarification by removal of suspended particles, as well as stabilization against formation of non-microbial haze via reduction of haze forming substances in various liquids. The haze forming substances are proteins and polyphenol tannins which occur in various plant related fluids such as beer wine, juices, flavorings, plant extracts, and even bioprocess streams. The method of the invention accomplishes both size based removal of colloidal non-haze related particles as well as adsorption based removal of haze forming substances without a need for added flocculants. The to method of the invention utilizes hydrophilic surfaces for adsorption of haze forming substances with such surfaces presented by materials arranged in manner so that size based exclusion of suspended particles is also achieved.
摘要翻译： 本发明涉及液体澄清和稳定化。 更为详细地，本发明涉及通过除去悬浮颗粒进行澄清，以及通过减少各种液体中的雾状物质而形成非微生物雾度的稳定性。 烟雾形成物质是发生在各种植物相关液体中的蛋白质和多酚单宁，例如啤酒，果汁，调味剂，植物提取物，甚至生物过程流。 本发明的方法完成了胶体非雾度相关颗粒的基于尺寸的去除以及基于吸附的去除雾状形成物质而不需要添加的絮凝剂。 本发明的方法利用亲水表面吸附具有这种表面的雾状形成物质，所述表面由以下方式排列：材料排列方式使悬浮颗粒的尺寸排除也得以实现。
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公开(公告)号：US20090281288A1
公开(公告)日：2009-11-12
申请号：US12506445
申请日：2009-07-21
申请人： JAMES VAN ALSTINE , Jan Bergstrom , Henrik Ihre , Tobias Soderman
发明人： JAMES VAN ALSTINE , Jan Bergstrom , Henrik Ihre , Tobias Soderman
CPC分类号： B01J20/3278 , B01D15/32 , B01D15/362 , B01D15/38 , B01D15/424 , B01J20/286 , B01J20/288 , B01J20/321 , B01J20/3212 , B01J20/327 , B01J20/328
摘要： The present invention relates to a separation matrix comprised of a support to the surfaces of which polymer chains have been coupled, wherein each polymer chain presents recurring proton-donating groups and at least the surface of the support is substantially hydrophilic. In the most advantageous embodiment, the support is porous cross-linked agarose, the polymers are poly(acrylic acid) and the proton-donating groups are carboxyl groups. The matrix is useful e.g. to remove PEG from pegylated and/or native compounds in a liquid. Accordingly, the invention also encompasses a method, such as a chromatographic method, wherein the separation matrix according to the invention is used, for example as a pre-treatment of a reaction mixture that comprises unreacted PEG, pegylated proteins and native proteins.
摘要翻译： 本发明涉及一种分离基质，其由其上已经连接有聚合物链的表面的载体组成，其中每个聚合物链呈现重复的质子供体基团，并且载体的至少表面基本上是亲水的。 在最有利的实施方案中，载体是多孔交联琼脂糖，聚合物是聚（丙烯酸），质子供体基团是羧基。 该矩阵是有用的。 以从液体中的聚乙二醇化和/或天然化合物中除去PEG。 因此，本发明还包括诸如色谱方法的方法，其中使用根据本发明的分离基质，例如作为包含未反应的PEG，聚乙二醇化蛋白质和天然蛋白质的反应混合物的预处理。
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