公开(公告)号：US20190170772A1

公开(公告)日：2019-06-06

申请号：US16093046

申请日：2017-04-14

申请人： MARS, INCORPORATED

发明人： Scott Joseph McGrane ,  Matthew Ronald Gibbs ,  Richard Masten Fine ,  Boris Klebansky

IPC分类号： G01N33/74

摘要： The present disclosure provides methods for identifying compounds that modulate the activity and/or expression of GPR92, wherein said compounds can be incorporated into flavor compositions that can be used to modify the taste and/or palatability of pet food products. In certain non-limiting embodiments, the present disclosure provides a method for identifying a composition that modulates the activity of a GPR92 receptor comprising (a) contacting a test agent with a GPR92 receptor, (b) determining the activity of the GPR92 receptor, and (c) selecting as the composition, a test agent that increases the activity of the GPR92 receptor.

公开(公告)号：US20190021380A1

公开(公告)日：2019-01-24

申请号：US15534440

申请日：2015-12-10

申请人： MARS, INCORPORATED

发明人： Scott Joseph McGrane ,  Andrew John Taylor ,  Richard Masten Fine ,  Jerry Wallace Skiles

IPC分类号： A23L27/23 ,  A23L27/21 ,  A23L27/20 ,  A23L27/00 ,  A23K20/111 ,  A23K20/132 ,  A23K50/42 ,  A23K20/153 ,  A23K20/142 ,  A23K50/48

摘要： A flavor composition comprising at least one transmembrane compound and/or at least one nucleotide derivative that modulates, increases and/or enhances the activity of an umami receptor is provided that can be used to enhance the umami taste and/or palatability of food products. In certain, non-limiting embodiments, the flavor composition comprises at least one nucleotide derivative and/or at least one transmembrane compound, optionally at least one nucleotide, optionally at least one first amino acid, optionally at least one second amino acid.

公开(公告)号：US11185100B2

公开(公告)日：2021-11-30

申请号：US15534434

申请日：2015-12-10

申请人： MARS, INCORPORATED

发明人： Scott Joseph McGrane ,  Andrew John Taylor ,  Richard Masten Fine ,  Boris Klebansky ,  Matthew Ronald Gibbs

IPC分类号： A23L27/23 ,  A23K20/132 ,  A23K20/153 ,  A23K50/42 ,  A23K50/48 ,  A23L27/00 ,  A23L27/20 ,  A23K20/111 ,  A23K20/142 ,  A23L27/21 ,  A23L27/22

摘要： Amino acids present in domains of an umami taste receptor are described herein, wherein the amino acids interact with at least one nucleotide derivative and/or at least one transmembrane compound that potentiates, modulates, increases, and/or enhances the activity of the umami receptor. Such compounds can be used in flavor compositions to enhance the umami taste and/or palatability of food products.

公开(公告)号：US20200292527A1

公开(公告)日：2020-09-17

申请号：US16885102

申请日：2020-05-27

申请人： MARS, INCORPORATED

发明人： Matthew Ronald Gibbs ,  Neil George Desforges ,  Andrew John Taylor ,  Scott Joseph McGrane ,  Boris Klebansky ,  Richard Masten Fine

IPC分类号： G01N33/50 ,  C07K14/72 ,  A23L27/00 ,  A23K20/147 ,  A23K50/40 ,  G01N33/566

摘要： The presently disclosed subject matter relates to methods of screening raw materials and pet food products to manufacture a palatable pet food product. The presently disclosed subject matter also relates to methods for identifying compounds that modulate the activity and/or expression of a bitter taste receptor.

公开(公告)号：US20190361039A1

公开(公告)日：2019-11-28

申请号：US16536088

申请日：2019-08-08

申请人： MARS, INCORPORATED

发明人： Scott Joseph McGrane ,  Andrew John Taylor ,  Matthew Ronald Gibbs ,  Richard Masten Fine ,  Boris Klebansky

IPC分类号： G01N33/74 ,  G16C20/60 ,  G16B35/00 ,  C07C53/126 ,  C07K14/705 ,  G01N33/566 ,  C07C57/03

摘要： The present invention relates to a method of identifying a compound that binds to or modulates the activity of one or more polypeptides encoding one or more receptors that are involved in the detection and perception of fatty acids.

公开(公告)号：US20190274334A1

公开(公告)日：2019-09-12

申请号：US16093025

申请日：2017-04-14

申请人： MARS, INCORPORATED

发明人： Scott Joseph McGrane ,  Matthew Ronald Gibbs ,  Richard Masten Fine ,  Boris Klebansky ,  Jerry Wallace Skiles

IPC分类号： A23K20/132 ,  A23K20/137 ,  A23K20/111 ,  A23K20/142 ,  A23K20/24 ,  A23K50/42 ,  A23K50/48 ,  A23L27/00

摘要： A flavor composition comprising at least one compound that modulates, increases and/or enhances the activity of a calcium-sensing receptor that can be used to enhance the kokumi taste and/or palatability of pet food products is described herein. Also disclosed herein are methods for identifying said compounds.

公开(公告)号：US20220087288A1

公开(公告)日：2022-03-24

申请号：US17252069

申请日：2019-06-13

申请人： MARS INCORPORATED

发明人： Scott Joseph McGrane ,  Matthew Ronald Gibbs ,  Boris Klebansky ,  Richard Masten Fine

IPC分类号： A23K50/40 ,  G01N33/566 ,  A23K40/00 ,  A23K20/142

摘要： The presently disclosed subject matter relates to methods of screening raw materials and pet food products to manufacture a palatable pet food product. The presently disclosed subject matter also relates to methods for identifying compounds that modulate the activity and/or expression of a taste receptor.

公开(公告)号：US10775375B2

公开(公告)日：2020-09-15

申请号：US16450462

申请日：2019-06-24

申请人： MARS, INCORPORATED

发明人： Scott Joseph McGrane ,  Andrew John Taylor ,  Richard Masten Fine ,  Boris Klebansky ,  Matthew Ronald Gibbs

IPC分类号： G01N33/566 ,  G01N33/84

摘要： Methods for identifying compounds that modulate the activity and/or expression of a calcium-sensing receptor, wherein said compounds can be incorporated into flavor compositions that can be used to modify the kokumi taste and/or palatability of pet food products.

公开(公告)号：US20180372721A1

公开(公告)日：2018-12-27

申请号：US15746658

申请日：2016-07-28

申请人： MARS, INCORPORATED

发明人： Matthew Ronald Gibbs ,  Neil George Desforges ,  Andrew John Taylor ,  Scott Joseph McGrane ,  Boris Klebansky ,  Richard Masten Fine

IPC分类号： G01N33/50 ,  A23K20/147 ,  A23L27/00 ,  C07K14/72 ,  A23K50/40

摘要： The presently disclosed subject matter relates to methods of screening raw materials and pet food products to manufacture a palatable pet food product. The presently disclosed subject matter also relates to methods for identifying compounds that modulate the activity and/or expression of a bitter taste receptor.

公开(公告)号：US20170367387A1

公开(公告)日：2017-12-28

申请号：US15534421

申请日：2015-12-10

申请人： MARS, INCORPORATED

发明人： Scott Joseph McGrane ,  Matthew Ronald Gibbs ,  Richard Masten Fine ,  Jerry Wallace Skiles

IPC分类号： A23L27/20 ,  A23L27/21 ,  A23L27/00 ,  A23K20/111 ,  A23K50/48 ,  A23K50/42 ,  A23K20/153 ,  A23L27/23 ,  A23K20/142

摘要： A flavor composition comprising at least one compound that modulates, increases and/or enhances the activity of a GPR120 fatty acid receptor that can be used to enhance the fatty acid taste and/or palatability of pet food products is described herein. Also disclosed herein are methods for identifying said compounds.