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公开(公告)号：US20160083803A1
公开(公告)日：2016-03-24
申请号：US14954496
申请日：2015-11-30
Inventor： Hongzhi Zou , David Ahlquist , Jonathan J. Harrington
IPC: C12Q1/68 , G01N33/574
CPC classification number: C12Q1/6886 , C12Q2600/154 , C12Q2600/156 , G01N33/57419 , G01N2333/805 , G01N2800/50 , G01N2800/7028
Abstract: The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals having a colorectal neoplasm by detecting the presence of exfoliated epithelial markers (e.g., human DNA, tumor assoicated gene alterations, tumor associated proteins) and blood markers (e.g., homoglobin, serum proteins) in a stool sample obtained from the mammal.
Abstract translation: 本发明提供与检测受试者粪便样品中或与受试者粪便样品相关的结肠直肠肿瘤特异性标志物相关的方法和材料。 特别地，本发明提供了通过检测剥离的上皮标志物（例如，人类DNA，肿瘤分解的基因改变，肿瘤相关蛋白）和血液标志物（例如，血红蛋白，血清蛋白质）的存在来鉴定具有结肠直肠肿瘤的哺乳动物的方法和材料 ）在从哺乳动物获得的粪便样品中。
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公开(公告)号：US10435753B2
公开(公告)日：2019-10-08
申请号：US14954496
申请日：2015-11-30
Inventor： Hongzhi Zou , David Ahlquist , Jonathan J. Harrington
IPC: C12Q1/6886 , G01N33/574
Abstract: The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals having a colorectal neoplasm by detecting the presence of exfoliated epithelial markers (e.g., human DNA, tumor assoicated gene alterations, tumor associated proteins) and blood markers (e.g., homoglobin, serum proteins) in a stool sample obtained from the mammal.
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公开(公告)号：US20240344140A1
公开(公告)日：2024-10-17
申请号：US18594650
申请日：2024-03-04
Inventor： Hongzhi Zou , David Ahlquist , Jonathan J. Harrington
IPC: C12Q1/6886 , G01N33/574
CPC classification number: C12Q1/6886 , G01N33/57419 , C12Q2600/154 , C12Q2600/156 , G01N2333/805 , G01N2800/50 , G01N2800/7028
Abstract: The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals having a colorectal neoplasm by detecting the presence of exfoliated epithelial markers (e.g., human DNA, tumor associated gene alterations, tumor associated proteins) and blood markers (e.g., hemoglobin, serum proteins) in a stool sample obtained from the mammal.
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公开(公告)号：US20190390286A1
公开(公告)日：2019-12-26
申请号：US16565022
申请日：2019-09-09
Inventor： Hongzhi Zou , David Ahlquist , Jonathan J. Harrington
IPC: C12Q1/6886 , G01N33/574
Abstract: The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals having a colorectal neoplasm by detecting the presence of exfoliated epithelial markers (e.g., human DNA, tumor assoicated gene alterations, tumor associated proteins) and blood markers (e.g., homoglobin, serum proteins) in a stool sample obtained from the mammal.
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