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    METHODS AND MATERIALS FOR DETECTING COLORECTAL CANCER AND ADENOMA
    1.
    发明申请
    METHODS AND MATERIALS FOR DETECTING COLORECTAL CANCER AND ADENOMA 审中-公开

    公开(公告)号：US20180187270A1

    公开(公告)日：2018-07-05

    申请号：US15899206

    申请日：2018-02-19

    Applicant: Mayo Foundation for Medical Education and Research

    Inventor： Hongzhi Zou ,  David A. Ahlquist

    IPC: C12Q1/6886

    CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158

    Abstract: The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers (e.g., markers associated with colorectal cancer, markers associated with adenoma) in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals (e.g., humans) having a colorectal neoplasm by detecting the presence and level of indicators of colorectal neoplasia such as, for example, long DNA (e.g., quantified by Alu PCR) and the presence and level of tumor-associated gene alterations (e.g., mutations in KRAS, APC, melanoma antigen gene, p53, BRAF, BAT26, PIK3CA) or epigenetic alterations (e.g., DNA methylation) (e.g., CpG methylation) (e.g., CpG methylation in coding or regulatory regions of bmp-3, bmp-4, SFRP2, vimentin, septin9, ALX4, EYA4, TFPI2, NDRG4, FOXE1) in DNA from a stool sample obtained from the mammal.

    DIGITAL SEQUENCE ANALYSIS OF DNA METHYLATION
    3.
    发明申请
    DIGITAL SEQUENCE ANALYSIS OF DNA METHYLATION 审中-公开
    DNA甲基化数字序列分析

    公开(公告)号：US20170073771A1

    公开(公告)日：2017-03-16

    申请号：US15278697

    申请日：2016-09-28

    Applicant: EXACT SCIENCES CORPORATION ,  MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

    Inventor： David A. Ahlquist ,  William R. Taylor ,  Hongzhi Zou ,  Graham P. Lidgard

    IPC: C12Q1/68

    Abstract: The present invention relates to methods and compositions for determination of and uses of specific methylation patterns indicative of adenoma and carcinoma. In particular, the invention relates to analysis of defined CpG loci that are coordinately methylated in DNAs from cancer and adenoma samples, methods for identifying coordinately methylated loci, and methods of using analysis of coordinately methylated loci in one or more marker regions in the design of assays for adenoma and cancer.

    Abstract translation: 本发明涉及用于确定和使用指示腺瘤和癌症的特异性甲基化模式的方法和组合物。 特别地，本发明涉及在来自癌症和腺瘤样品的DNA中配位甲基化的定义的CpG基因座的分析，用于鉴定配位甲基化位点的方法以及在设计中的一个或多个标记区域中使用配位甲基化位点分析的方法 腺瘤和癌症检测。

    METHODS AND MATERIALS FOR DETECTING COLORECTAL NEOPLASM
    4.
    发明申请
    METHODS AND MATERIALS FOR DETECTING COLORECTAL NEOPLASM 审中-公开
    检测色素沉积物的方法和材料

    公开(公告)号：US20160083803A1

    公开(公告)日：2016-03-24

    申请号：US14954496

    申请日：2015-11-30

    Applicant: Mayo Foundation for Medical Education and Research

    Inventor： Hongzhi Zou ,  David Ahlquist ,  Jonathan J. Harrington

    IPC: C12Q1/68 ,  G01N33/574

    CPC classification number: C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/156 ,  G01N33/57419 ,  G01N2333/805 ,  G01N2800/50 ,  G01N2800/7028

    Abstract: The present invention provides methods and materials related to the detection of colorectal neoplasm-specific markers in or associated with a subject's stool sample. In particular, the present invention provides methods and materials for identifying mammals having a colorectal neoplasm by detecting the presence of exfoliated epithelial markers (e.g., human DNA, tumor assoicated gene alterations, tumor associated proteins) and blood markers (e.g., homoglobin, serum proteins) in a stool sample obtained from the mammal.

    Abstract translation: 本发明提供与检测受试者粪便样品中或与受试者粪便样品相关的结肠直肠肿瘤特异性标志物相关的方法和材料。 特别地，本发明提供了通过检测剥离的上皮标志物（例如，人类DNA，肿瘤分解的基因改变，肿瘤相关蛋白）和血液标志物（例如，血红蛋白，血清蛋白质）的存在来鉴定具有结肠直肠肿瘤的哺乳动物的方法和材料 ）在从哺乳动物获得的粪便样品中。

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