公开(公告)号：US10076404B2

公开(公告)日：2018-09-18

申请号：US13795248

申请日：2013-03-12

Applicant: Medrad, Inc.

Inventor： Michael J. Bonnette

IPC: A61M29/00 ,  A61F2/01 ,  A61M25/10

CPC classification number: A61F2/013 ,  A61F2230/0058 ,  A61F2230/0071 ,  A61F2230/0091 ,  A61F2250/0003 ,  A61M25/1002 ,  A61M2025/1081

Abstract: A catheter system includes an inflatable structural balloon and collapsible filter. The collapsible filter is deployable into an expanded configuration using the inflatable distal balloon. In the expanded configuration, one or more flow cells are formed between inflated portions of the balloon to provide continuous fluid flow between proximal and distal ends of the structural balloon. In the expanded configuration, the filter is configured to prevent particulates (e.g., dislodged thrombus, or other particulate material) from migrating beyond the filter. In the expanded configuration, the inflated structural balloon biases a perimeter of the filter toward or against a subject vessel wall.

公开(公告)号：US20140276602A1

公开(公告)日：2014-09-18

申请号：US13801581

申请日：2013-03-13

Applicant: MEDRAD, INC.

Inventor： Michael J. Bonnette ,  Leif E. Leirfallom

IPC: A61M25/00 ,  A61M25/01 ,  A61M5/142

CPC classification number: A61M25/007 ,  A61B17/22 ,  A61B17/32037 ,  A61B2017/00991 ,  A61B2017/22084 ,  A61M5/007 ,  A61M5/142 ,  A61M25/01 ,  A61M25/0105 ,  A61M2025/0004 ,  A61M2025/0008 ,  A61M2025/006 ,  A61M2025/0079 ,  A61M2025/0175

Abstract: A multi-station hydrodynamic catheter includes an outer catheter having a first lumen, the outer catheter having a plurality of orifice stations positioned along a portion of the outer catheter, where each orifice station includes one or more orifices extending from an outer catheter external surface to the first lumen. The multi-station hydrodynamic catheter includes an inner catheter having a second lumen, the inner catheter movable within the first lumen and includes at least one emanator, where the at least one emanator includes one or more fluid delivery ports extending from an inner catheter external surface to the second lumen.

Abstract translation: 多站流体动力导管包括具有第一腔的外导管，所述外导管具有沿着外导管的一部分定位的多个孔台，其中每个孔台包括从外导管外表面延伸到一个或多个孔口 第一个流明。 所述多工位流体动力导管包括具有第二内腔的内导管，所述内导管可在所述第一腔内移动并且包括至少一个发射器，其中所述至少一个发射器包括从内导管外表面延伸的一个或多个流体输送端口 到第二个流明。

公开(公告)号：US20140228869A1

公开(公告)日：2014-08-14

申请号：US13766367

申请日：2013-02-13

Applicant: MEDRAD, INC.

Inventor： Michael J. Bonnette ,  Eric J. Thor

IPC: A61B17/3203

CPC classification number: A61B17/32037 ,  A61B2017/22039 ,  A61B2017/22079 ,  A61B2217/005 ,  A61B2217/007

Abstract: A thrombectomy catheter includes a catheter body extending from a catheter proximal portion to a catheter distal portion and including a catheter intermediate portion, the catheter body includes an aspiration lumen and an infusion lumen extending along the catheter body, wherein the aspiration lumen includes an aspiration orifice open at a distal end of the catheter body.

Abstract translation: 血栓切除导管包括从导管近端部分延伸到导管远端部分并且包括导管中间部分的导管主体，所述导管主体包括沿着导管主体延伸的抽吸腔和输注腔，其中所述抽吸腔包括抽吸孔 在导管主体的远端处打开。

公开(公告)号：US20130131691A1

公开(公告)日：2013-05-23

申请号：US13741342

申请日：2013-01-14

Applicant: Medrad, Inc.

Inventor： Debra M. Kozak ,  Michael J. Bonnette ,  Eric J. Thor ,  David B. Morris ,  John L. Teschendorf ,  Douglas J. Ball ,  Michael Schrom ,  Stephen E. Weisel

IPC: A61B17/22

CPC classification number: A61B17/22 ,  A61B17/32037 ,  A61B2017/22038 ,  A61B2017/22041 ,  A61M25/007 ,  A61M2025/0183

Abstract: Catheters including guidewire tubes having a limited length and methods of using the catheters are described. The catheters may be delivered over guidewires in procedures that are commonly referred to as rapid-exchange delivery. In some embodiments, the catheters may be miniature flexible thrombectomy catheters that may be used to remove thrombus or other unwanted material from a body blood vessel or other small regions of body cavities in which the distal portion of the catheter has smaller external dimensions than the larger proximal portion

Abstract translation: 描述了包括有限长度的导丝管和使用导管的方法的导管。 导管可以在通常被称为快速交换递送的程序中通过导线输送。 在一些实施例中，导管可以是微型柔性血栓切除术导管，其可以用于从身体血管或体腔的其他小区域去除血栓或其它不需要的材料，其中导管的远端部分具有比较大的外部尺寸更小的外部尺寸 近端部分

公开(公告)号：US20140277006A1

公开(公告)日：2014-09-18

申请号：US13827208

申请日：2013-03-14

Applicant: Medrad, Inc.

Inventor： Michael J. Bonnette ,  Eric J. Thor ,  Jason M. Bronstad ,  Michael Schrom ,  Leif E. Leirfallom ,  Debra M. Kozak

IPC: A61B17/3203 ,  A61M25/01

CPC classification number: A61B17/32037 ,  A61B2017/00455 ,  A61B2090/0811

Abstract: Thrombectomy catheters having at least one outflow orifice and one or more inflow orifices, systems including the thrombectomy catheters, and methods of using the thrombectomy catheters are described herein. The thrombectomy catheters described herein may include one or more of the protective features that may limit potential hazards to vessel walls in which the thrombectomy catheters are used.

Abstract translation: 本文描述了具有至少一个流出孔和一个或多个入口的血栓切除导管，包括血栓切除术导管的系统，以及使用血栓切除术导管的方法。 本文所述的血栓切除术导管可以包括一个或多个保护特征，其可以限制使用血栓切除导管的血管壁的潜在危险。

公开(公告)号：US20140257097A1

公开(公告)日：2014-09-11

申请号：US13794528

申请日：2013-03-11

Applicant: MEDRAD, INC.

Inventor： Michael J. Bonnette ,  David B. Morris

IPC: A61M5/00

CPC classification number: A61M5/1422 ,  A61M5/007 ,  A61M5/14212 ,  A61M5/14216 ,  A61M2005/1403 ,  A61M2206/22 ,  F04B5/02 ,  F04B9/109 ,  F04B9/1095 ,  F04B11/0041

Abstract: An infusion system includes a double action infusion pump. The pump includes a cylinder and a reciprocating piston received within the cylinder, the reciprocating piston separating a first pump chamber from a second pump chamber of the cylinder. A reciprocating motor is coupled with the reciprocating piston, and the first and second pump chambers alternate between filling and evacuating conditions with reciprocation of the reciprocating piston through operation of the reciprocating motor, and the speed of reciprocation is varied to provide a continuous output of fluid between the first and second pump chambers. A fluid source and a catheter are optionally coupled with the double action infusion pump. The catheter includes one or more infusion ports near a catheter distal portion, and the one or more infusion ports receive and expel the continuous output of fluid from the double action infusion pump.

Abstract translation: 输液系统包括双作用输液泵。 泵包括容纳在气缸内的气缸和往复活塞，往复运动的活塞将第一泵室与气缸的第二泵室分开。 往复运动马达与往复运动的活塞联接，并且第一和第二泵室在往复运动的活塞通过往复式马达的运动往复运动的情况下在填充和抽空条件之间交替，并且往复运动的速度被改变以提供流体的连续输出 在第一和第二泵室之间。 流体源和导管任选地与双作用输液泵相连。 导管包括靠近导管远端部分的一个或多个输注端口，并且一个或多个输注端口接收并排出来自双作用输注泵的流体的连续输出。

公开(公告)号：US20140214060A1

公开(公告)日：2014-07-31

申请号：US14115907

申请日：2012-05-18

Applicant: MEDRAD, Inc

Inventor： Michael J. Bonnette ,  Richard R. Prather ,  David B. Morris ,  Eric J. Thor ,  Nicole J. Aasen ,  Debra M. Kozak ,  Arthur E. Uber, III

IPC: A61B17/3207 ,  A61B17/3203

CPC classification number: A61B17/3207 ,  A61B17/32037 ,  A61B17/320725 ,  A61B17/32075 ,  A61B2017/2215 ,  A61B2017/320008 ,  A61B2017/320012 ,  A61B2217/005 ,  A61B2217/007

Abstract: A catheter assembly includes an inner mandrel and an outer sheath slidably coupled along the inner mandrel. The catheter assembly includes a scrubbing assembly coupled between the inner mandrel and the outer sheath. The scrubbing assembly includes a plurality of deformable struts deflectable according to movement of the inner mandrel relative to the outer sheath. The scrubbing assembly includes a proximal shoulder coupled with the outer sheath, and a distal shoulder coupled with the inner mandrel. The plurality of struts extend between the proximal and distal shoulders. The scrubbing assembly is movable between a stored configuration and a deployed configuration according to movement of the inner mandrel relative to the outer sheath. In the stored configuration the proximal and distal shoulders are remote from each other. In the deployed configuration the proximal shoulder is engaged with the distal shoulder, and the deformable struts are deflected into bristles.

Abstract translation: 导管组件包括内心轴和沿内心轴可滑动联接的外护套。 导管组件包括耦合在内心轴和外护套之间的洗涤组件。 洗涤组件包括多个可变形的支柱，其可根据内心轴相对于外护套的移动而偏转。 洗涤组件包括与外护套耦合的近侧肩部和与内心轴联接的远侧肩部。 多个支柱在近端和远端之间延伸。 洗涤组件可以根据内心轴相对于外护套的移动而在存储构型和展开构型之间移动。 在存储的配置中，近端和远端肩部彼此远离。 在所展开的构造中，近侧肩部与远端肩部接合，并且可变形支柱偏转到刷毛中。

公开(公告)号：US08657777B2

公开(公告)日：2014-02-25

申请号：US13741342

申请日：2013-01-14

Applicant: Medrad, Inc.

Inventor： Debra M. Kozak ,  Michael J. Bonnette ,  Eric J. Thor ,  David B. Morris ,  John L. Teschendorf ,  Douglas J. Ball ,  Michael Schrom ,  Stephen E. Weisel

IPC: A61M1/00

CPC classification number: A61B17/22 ,  A61B17/32037 ,  A61B2017/22038 ,  A61B2017/22041 ,  A61M25/007 ,  A61M2025/0183

Abstract: Catheters including guidewire tubes having a limited length and methods of using the catheters are described. The catheters may be delivered over guidewires in procedures that are commonly referred to as rapid-exchange delivery. In some embodiments, the catheters may be miniature flexible thrombectomy catheters that may be used to remove thrombus or other unwanted material from a body blood vessel or other small regions of body cavities in which the distal portion of the catheter has smaller external dimensions than the larger proximal portion.

Abstract translation: 描述了包括有限长度的导丝管和使用导管的方法的导管。 导管可以在通常被称为快速交换递送的程序中通过导线输送。 在一些实施例中，导管可以是微型柔性血栓切除术导管，其可以用于从身体血管或体腔的其他小区域去除血栓或其它不需要的材料，其中导管的远端部分具有比较大的外部尺寸更小的外部尺寸 近端部分。

公开(公告)号：US20140277007A1

公开(公告)日：2014-09-18

申请号：US13830699

申请日：2013-03-14

Applicant: MEDRAD, INC.

Inventor： Michael J. Bonnette

IPC: A61B17/3203

CPC classification number: A61B17/32037 ,  A61B2017/22039 ,  A61B2017/22041 ,  A61B2017/22079 ,  A61F2/013 ,  A61F2002/016

Abstract: A hydrodynamic catheter includes a catheter body with a catheter lumen and an infusion tube extending within the catheter body, the infusion tube configured for coupling with a fluid source near the catheter proximal portion. An inflow orifice and an outflow orifice are positioned at locations along a catheter body perimeter. A fluid jet emanator is in fluid communication with the infusion tube, where the fluid jet emanator includes one or more jet orifices configured to direct one or more fluid jets through the catheter lumen from near the inflow orifice toward the outflow orifice. A pivot cylinder located along the catheter body perimeter is positioned distal relative to one or more of the fluid jet emanator, the inflow orifice, or the outflow orifice.

Abstract translation: 流体动力导管包括具有导管内腔的导管主体和在导管主体内延伸的输液管，该输液管构造成用于与导管近端部分附近的流体源耦合。 入口孔和流出口位于导管主体周边的位置。 流体喷射发生器与输液管流体连通，其中流体喷射发生器包括一个或多个喷射孔，其构造成将一个或多个流体射流引导通过导管腔从入口孔附近朝向流出孔。 沿着导管主体周边定位的枢轴圆筒相对于流体喷射发生器，流入孔或流出孔中的一个或多个定位在远侧。

公开(公告)号：US20140005699A1

公开(公告)日：2014-01-02

申请号：US13794350

申请日：2013-03-11

Applicant: MEDRAD, INC.

Inventor： Michael J. Bonnette ,  Debra M. Kozak ,  Eric J. Thor

IPC: A61B17/3207

CPC classification number: A61B17/320758 ,  A61B17/320725 ,  A61B2017/22079 ,  A61B2217/005 ,  A61B2217/007

Abstract: An atherectomy and thrombectomy system includes a catheter body extending between proximal and distal catheter portions. The catheter body includes an aspiration lumen extending therein. An atherectomy assembly is coupled with the distal catheter portion and includes a rotatable cutter. A thrombectomy assembly is coupled with the distal catheter portion. The thrombectomy assembly includes a jet body within the aspiration lumen, and inflow and outflow orifices extending through the catheter body and in communication with the aspiration lumen. In a thrombectomy configuration a cyclical flow is generated by the jet body through the outflow and inflow orifices to hydrodynamically abrade thrombus, the cyclical flow entrains thrombus and delivers thrombus into the aspiration lumen. In the atherectomy configuration the rotatable cutter cuts plaque into plaque particulate, and the cyclical flow of the thrombectomy assembly entrains the particulate and delivers the particulate into the aspiration lumen.

Abstract translation: 粥样斑块切除术和血栓切除术系统包括在近端和远端导管部分之间延伸的导管体。 导管主体包括在其中延伸的抽吸腔。 动脉粥样组织切除术组件与远侧导管部分联接并且包括可旋转切割器。 血栓切除术组件与远侧导管部分联接。 血栓切除组件包括抽吸腔内的喷射体，以及延伸穿过导管主体并与抽吸腔连通的流入口和出口孔。 在血栓切除结构中，射流体通过流出孔和流入口产生循环流动以流体动力学研磨血栓，循环流动引起血栓并将血栓输送到抽吸腔。 在粥样斑块切除配置中，可旋转切割器将牙斑切割成斑块颗粒，并且血栓切除术组件的循环流动夹带颗粒并将颗粒输送到抽吸腔中。