-
公开(公告)号：US11752128B2
公开(公告)日：2023-09-12
申请号：US17385194
申请日：2021-07-26
发明人： John P. Caldwell , Ginny Dai Ho , Sookhee N. Ha , Sandra J. Koseoglu , Marc A. Labroli , Sang Ho Lee , Christina Madsen-Duggan , Mihir Mandal , Jianping Pan , Weidong Pan , Terry Roemer , Jing Su , Christopher Michael Tan , Zheng Tan , Hao Wang , Christine Yang , Shu-Wei Yang
IPC分类号： A61K31/397 , A61P31/04 , A61K31/407 , C07D235/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04
CPC分类号： A61K31/397 , A61K31/407 , A61P31/04 , C07D235/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04
摘要： Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.
-
公开(公告)号：US11141410B2
公开(公告)日：2021-10-12
申请号：US16061519
申请日：2016-12-13
发明人： John P. Caldwell , Reynalda De Jesus , Fa-Xiang Ding , Charles J. Gill , Ginny Dai Ho , Sookhee N. Ha , Sandra J. Koseoglu , Marc A. Labroli , Sang Ho Lee , Christina Madsen-Duggan , Mihir Mandal , Terry Roemer , Jing Su , Christopher Michael Tan , Zheng Tan , Haifeng Tang , Hao Wang , Christine Yang , Shu-Wei Yang
IPC分类号： A61K31/4439 , A61P31/04 , A61K31/407 , A61K31/421 , A61K31/422 , A61K31/427 , A61K31/431 , A61K31/4375 , A61K31/438 , A61K31/4709 , A61K31/5377 , A61K31/5383 , C07D263/26 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D491/048 , C07D495/04 , C07D498/04
摘要： Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.
-
公开(公告)号：US10689430B2
公开(公告)日：2020-06-23
申请号：US16301010
申请日：2017-05-23
发明人： Songnian Lin , Lin Yan , Pei Huo , Dmitri Pissarnitski , Danqing Feng , Ravi Nargund , Christina Madsen-Duggan , Yuping Zhu , Ahmet Kekec , Zhicai Wu
摘要： Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.
-
公开(公告)号：US11738010B2
公开(公告)日：2023-08-29
申请号：US17385258
申请日：2021-07-26
发明人： John P. Caldwell , Reynalda De Jesus , Fa-Xiang Ding , Charles J. Gill , Ginny Dai Ho , Sookhee N. Ha , Sandra J. Koseoglu , Marc A. Labroli , Sang Ho Lee , Christina Madsen-Duggan , Mihir Mandal , Terry Roemer , Jing Su , Christopher Michael Tan , Zheng Tan , Haifeng Tang , Hao Wang , Christine Yang , Shu-Wei Yang
IPC分类号： A61K31/4439 , A61P31/04 , A61K31/407 , A61K31/421 , A61K31/422 , A61K31/427 , A61K31/431 , A61K31/4375 , A61K31/438 , A61K31/4709 , A61K31/5377 , A61K31/5383 , C07D263/26 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D491/048 , C07D495/04 , C07D498/04
CPC分类号： A61K31/4439 , A61K31/407 , A61K31/421 , A61K31/422 , A61K31/427 , A61K31/431 , A61K31/438 , A61K31/4375 , A61K31/4709 , A61K31/5377 , A61K31/5383 , A61P31/04 , C07D263/26 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D491/048 , C07D495/04 , C07D498/04
摘要： Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.
-
公开(公告)号：US11141403B2
公开(公告)日：2021-10-12
申请号：US16061481
申请日：2016-12-13
申请人： MERCK SHARP & DOHME CORP. , John P. Caldwell , Ginny Dai Ho , Sookhee N. Ha , Sandra J. Koseoglu , Marc A. Labroli , Sang Ho Lee , Christina Madsen-Duggan , Mihir Mandal , Jianping Pan , Weidong Pan , Terry Roemer , Jing Su , Christopher Michael Tan , Zheng Tan , Hao Wang , Christine Yang , Shu-Wei Yang
发明人： John P. Caldwell , Ginny Dai Ho , Sookhee N. Ha , Sandra J. Koseoglu , Marc A. Labroli , Sang Ho Lee , Christina Madsen-Duggan , Mihir Mandal , Jianping Pan , Weidong Pan , Terry Roemer , Jing Su , Christopher Michael Tan , Zheng Tan , Hao Wang , Christine Yang , Shu-Wei Yang
IPC分类号： A61K31/397 , A61P31/04 , A61K31/407 , C07D235/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D471/04
摘要： Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.
-
公开(公告)号：US20190177393A1
公开(公告)日：2019-06-13
申请号：US16301010
申请日：2017-05-23
发明人： Songnian Lin , Lin Yan , Pei Huo , Dmitri Pissarnitski , Danqing Feng , Ravi Nargund , Christina Madsen-Duggan , Yuping Zhu , Ahmet Kekec , Zhicai Wu
摘要： Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.
-
-
-
-
-
搜索结果
6 条记录 (耗时 0.02 秒)
