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1.发明申请公开(公告)号：US20150353535A1
公开(公告)日：2015-12-10
申请号：US14653488
申请日：2013-12-19
发明人： Michael D. Altman , Brian M. Andresen , Kenneth L. Arrington , Kaleen Konrad Childers , Maria Emilia Di Francesco , John Michael Ellis , Andrew M. Haidle , Yuan Liu , Alan B. Northrup , Brendan O'Boyle , Ryan D. Otte , Michael H. Reutershan , Dilrukshi Vitharana , Hyun Chong Woo
IPC分类号： C07D417/14 , A61K31/444
CPC分类号： C07D417/14 , A61K31/444 , A61K45/06
摘要： The invention provides certain thiazole-substituted aminopyridine compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Cy, and the subscript t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
摘要翻译： 本发明提供了式（I）（I）的某些噻唑取代的氨基吡啶化合物或其药学上可接受的盐，其中R1，R2，R3，R4，R5，R6，Cy和下标t如本文所定义。 本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）介导的疾病或病症的方法。
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公开(公告)号：US09598405B2
公开(公告)日：2017-03-21
申请号：US14653488
申请日：2013-12-19
发明人： Michael D. Altman , Brian M. Andresen , Kenneth L. Arrington , Kaleen Konrad Childers , Maria Emilia Di Francesco , John Michael Ellis , Andrew M. Haidle , Yuan Liu , Alan B. Northrup , Brendan O'Boyle , Ryan D. Otte , Michael H. Reutershan , Dilrukshi Vitharana , Hyun Chong Woo
IPC分类号： C07D413/04 , C07D417/14 , A61K31/444 , A61K45/06
CPC分类号： C07D417/14 , A61K31/444 , A61K45/06
摘要： The invention provides certain thiazole-substituted aminopyridine compounds of the Formula (I) (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Cy, and the subscript t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
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公开(公告)号：US09242984B2
公开(公告)日：2016-01-26
申请号：US14409133
申请日：2013-06-18
发明人： Michelle R. Machacek , Michael D. Altman , Eric T. Romeo , Dilrukshi Vitharana , Brandon Cash , Tony Siu , Hua Zhou , Matthew Christopher , Solomon D. Kattar , Andrew M. Haidle , Kaleen Konrad Childers , Matthew L. Maddess , Michael H. Reutershan , Yves Ducharme , David J. Guerin , Kerrie Spencer , Christian Beaulieu , Vouy Linh Truong , Daniel Guay , Alan B. Northrup , Brandon M. Taoka , Jongwon Lim , Christian Fischer , John W. Butcher , Ryan D. Otte , Binyuan Sun , John Michael Ellis
IPC分类号： C07D401/00 , A61K31/00 , C07D471/04 , C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D403/14 , C07D409/14
CPC分类号： C07D471/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
摘要翻译： 本发明提供了式I的新型吡唑衍生物，其是脾脏酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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公开(公告)号：US09670196B2
公开(公告)日：2017-06-06
申请号：US15105316
申请日：2014-12-18
发明人： Thomas A. Miller , Alessia Petrocchi , Eric T. Romeo , Dilrukshi Vitharana , Solomon D. Kattar , Alan B. Northrup , Michael D. Altman , Neville J. Anthony
IPC分类号： C07D417/12 , C07D417/14 , C07D413/12 , C07D471/04 , C07D491/048 , C07D495/04 , A61K31/437 , A61K31/444 , A61K31/517 , A61K31/519
CPC分类号： C07D417/12 , A61K31/437 , A61K31/444 , A61K31/517 , A61K31/519 , C07D413/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) (I), or pharmaceutically acceptable salts thereof, wherein ring R1, R2, R3, R4, ring A, and the subscripts n1, n2, and r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
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5.发明申请公开(公告)号：US20160326156A1
公开(公告)日：2016-11-10
申请号：US15105316
申请日：2014-12-18
申请人： Thomas A. MILLER , Alessia PETROCCHI , Eric T. ROMEO , Dilrukshi VITHARANA , Solomon D. KATTAR , Alan B. NORTHRUP , Michael D. ALTMAN , Neville J. ANTHONY , MERCK SHARP & DOHME CORP.
发明人： Thomas A. Miller , Alessia Petrocchi , Eric T. Romeo , Dilrukshi Vitharana , Solomon D. Kattar , Alan B. Northrup , Michael D. Altman , Neville J. Anthony
IPC分类号： C07D417/12 , C07D495/04 , A61K31/437 , C07D471/04 , A61K31/444 , C07D491/048 , A61K31/517 , A61K31/519
CPC分类号： C07D417/12 , A61K31/437 , A61K31/444 , A61K31/517 , A61K31/519 , C07D413/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) (I), or pharmaceutically acceptable salts thereof, wherein ring R1, R2, R3, R4, ring A, and the subscripts n1, n2, and r are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).
摘要翻译： 本发明提供了式（I）（I）的某些噻唑取代的氨基杂芳基化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，环A和下标n 1，n 2和r如上定义 这里。 本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗由脾脏酪氨酸激酶（Syk）介导的疾病或病症的方法。
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公开(公告)号：US20150191461A1
公开(公告)日：2015-07-09
申请号：US14409133
申请日：2013-06-18
发明人： Michelle R. Machacek , Michael D. Altman , Eric T. Romeo , Dilrukshi Vitharana , Brandon Cash , Tony Siu , Matthew Christopher , Solomon D. Kattar , Andrew M. Haidle , Kaleen Konrad Childers , Matthew L. Maddess , Michael H. Reutershan , Yves Ducharme , David J. Guerin , Kerrie Spencer , Christian Beaulieu , Vouy Linh Truong , Daniel Guay , Alan B. Northrup , Brandon M. Taoka , Jongwon Lim , Christian Fischer , John W. Butcher , Ryan D. Otte , Binyuan Sun , John Michael Ellis
IPC分类号： C07D471/04 , C07D401/14 , C07D413/14 , C07D409/14 , C07D403/14 , C07D403/12
CPC分类号： C07D471/04 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides novel pyrazole derivatives of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
摘要翻译： 本发明提供了式I的新型吡唑衍生物，其是脾脏酪氨酸激酶的有效抑制剂，并且可用于治疗和预防由所述酶介导的疾病，例如哮喘，COPD，类风湿性关节炎和癌症。
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