公开(公告)号：US20180064719A1

公开(公告)日：2018-03-08

申请号：US15801109

申请日：2017-11-01

Applicant: MERIAL INC.

Inventor： Rolf Valter Attstrom ,  Hugo De Bruyn

IPC: A61K31/5377 ,  A61Q11/00 ,  A61K8/49

CPC classification number: A61K8/49 ,  A23K1/1628 ,  A61K31/5377 ,  A61K2800/74 ,  A61Q11/00 ,  C07D265/30

Abstract: Use of a compound having the formula (I) in the manufacture of a medicament for the prevention or treatment of a disease caused by oral bacteria in an animal wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof. A cosmetic method of preventing or decreasing oral staining in an animal, comprising the step of exposing the oral cavity to a morpholino compound of general

公开(公告)号：US20180085374A1

公开(公告)日：2018-03-29

申请号：US15726413

申请日：2017-10-06

Applicant: MERIAL INC.

Inventor： Rolf Valter Attstrom

IPC: A61K31/5375 ,  A61Q11/00 ,  A61K8/49 ,  A61K45/06

CPC classification number: A61K31/5375 ,  A61K8/49 ,  A61K45/06 ,  A61K2300/00 ,  A61Q11/00

Abstract: Use of a morpholino compound having the general formula (I) wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the prevention or treatment of halitosis.

公开(公告)号：US10206928B2

公开(公告)日：2019-02-19

申请号：US15801109

申请日：2017-11-01

Applicant: MERIAL INC.

Inventor： Rolf Valter Attstrom ,  Hugo De Bruyn

IPC: A61K31/5377 ,  A61K8/49 ,  A61Q11/00

Abstract: Use of a compound having the formula (I) in a medicament for the prevention or treatment of a disease caused by oral bacteria in an animal wherein R1 is a straight or branched alkyl group containing 8 to 16 carbon atoms at the 2- or 3-position of the morpholino ring, and R2 is a straight or branched alkyl group containing 2 to 10 carbon atoms, substituted with a hydroxy group except in the alpha-position, or a pharmaceutically acceptable salt thereof.