公开(公告)号：US20200057070A1

公开(公告)日：2020-02-20

申请号：US16653268

申请日：2019-10-15

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Anu Mathew ,  Martin Stengelin ,  Mingyue Wang

IPC: G01N33/574

Abstract: The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US10408823B2

公开(公告)日：2019-09-10

申请号：US15311309

申请日：2015-05-15

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  George Sigal ,  Martin Stengelin ,  David Routenberg

IPC: C12Q1/6832 ,  C12Q1/6837 ,  G01N33/543 ,  C12Q1/6844

Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.

公开(公告)号：US20190391140A1

公开(公告)日：2019-12-26

申请号：US16564208

申请日：2019-09-09

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  George Sigal ,  Martin Stengelin ,  David Routenberg

IPC: G01N33/543 ,  C12Q1/6844 ,  C12Q1/6837 ,  C12Q1/6832

Abstract: The present invention is directed to methods for improving assay specificity and performance in binding assays.

公开(公告)号：US20180074061A1

公开(公告)日：2018-03-15

申请号：US15813418

申请日：2017-11-15

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Galina Nikolenko ,  Martin Stengelin ,  Srikant Vaithilingam

IPC: G01N33/574

CPC classification number: G01N33/57423 ,  G01N2800/52

Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US20170168047A1

公开(公告)日：2017-06-15

申请号：US15440191

申请日：2017-02-23

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  George Sigal ,  Martin Stengelin

IPC: G01N33/543 ,  C12Q1/68 ,  G01N21/66 ,  G01N21/76 ,  G01N21/77 ,  G01N33/53 ,  G01N33/58

CPC classification number: G01N33/54393 ,  C12Q1/6804 ,  G01N21/66 ,  G01N21/76 ,  G01N21/77 ,  G01N33/5306 ,  G01N33/5308 ,  G01N33/533 ,  G01N33/54306 ,  G01N33/56988 ,  G01N33/582 ,  G01N2021/7786 ,  C12Q2537/125 ,  C12Q2563/179

Abstract: The present disclosure is directed to a kit for the detection of an analyte of interest in a sample comprising, in one or more vials, containers, or compartments, a. a surface comprising (i) a capture reagent for the analyte, said capture reagent bound to the surface, and (ii) an anchoring reagent bound to an anchoring oligonucleotide sequence, said anchoring reagent bound to the surface, b. a first detection reagent for the analyte that is linked to a first nucleic acid probe, wherein the first nucleic acid probe comprises an extended sequence that is complementary to the anchoring oligonucleotide sequence and c. a second detection reagent for the analyte that is linked to a second nucleic acid probe.

公开(公告)号：US20240361322A1

公开(公告)日：2024-10-31

申请号：US18538543

申请日：2023-12-13

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Galina Nikolenko ,  Martin Stengelin

IPC: G01N33/574 ,  A61K39/395

CPC classification number: G01N33/57423 ,  A61K39/39533

Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US11525825B2

公开(公告)日：2022-12-13

申请号：US16564208

申请日：2019-09-09

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  George Sigal ,  Martin Stengelin ,  David Routenberg

IPC: C12Q1/6832 ,  C12Q1/6837 ,  C12Q1/6844 ,  G01N33/543

Abstract: The present invention is directed to kits for improving assay specificity and performance in binding assays.

公开(公告)号：US10908157B2

公开(公告)日：2021-02-02

申请号：US15440191

申请日：2017-02-23

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  George Sigal ,  Martin Stengelin

IPC: G01N33/533 ,  G01N33/543 ,  G01N33/569 ,  G01N33/53 ,  C12Q1/6804 ,  G01N21/66 ,  G01N21/76 ,  G01N21/77 ,  G01N33/58

Abstract: The present disclosure is directed to a kit for the detection of an analyte of interest in a sample comprising, in one or more vials, containers, or compartments, a. a surface comprising (i) a capture reagent for the analyte, said capture reagent bound to the surface, and (ii) an anchoring reagent bound to an anchoring oligonucleotide sequence, said anchoring reagent bound to the surface, b. a first detection reagent for the analyte that is linked to a first nucleic acid probe, wherein the first nucleic acid probe comprises an extended sequence that is complementary to the anchoring oligonucleotide sequence and c. a second detection reagent for the analyte that is linked to a second nucleic acid probe.

公开(公告)号：US20170160281A1

公开(公告)日：2017-06-08

申请号：US15440136

申请日：2017-02-23

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Galina Nikolenko ,  Martin Stengelin

IPC: G01N33/574

CPC classification number: G01N33/57423 ,  A61K39/39533

Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US20220397579A1

公开(公告)日：2022-12-15

申请号：US17773896

申请日：2020-11-04

Applicant: MESO SCALE TECHNOLOGIES, LLC.

Inventor： Sunsanee Kanjananimmanont ,  Sudeep Kumar ,  Navaratnam Manjula ,  Simone Barbero ,  Martin Stengelin ,  George Sigal

IPC: G01N33/68 ,  G01N33/543

Abstract: The invention relates to methods and kits for quantitating radiation exposure in a subject exposed to radiation, at risk of exposure to radiation or suspected of having been exposed to radiation. In embodiments, the present disclosure provides multiplexed immunoassays for quantifying amounts of biomarkers for assessing radiation exposure in a sample. Also provided herein are kits for performing the multiplexed assays.