公开(公告)号：US10436784B2

公开(公告)日：2019-10-08

申请号：US14854514

申请日：2015-09-15

Applicant: Meso Scale Technologies, LLC ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

Inventor： William F Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC: G01N33/53 ,  G01N33/569 ,  G01N33/68 ,  G01N33/566

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US20180246100A1

公开(公告)日：2018-08-30

申请号：US15902597

申请日：2018-02-22

Applicant: Meso Scale Technologies, LLC. ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

Inventor： William F. Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC: G01N33/569 ,  G01N33/566 ,  G01N33/68

CPC classification number: G01N33/56972 ,  G01N33/566 ,  G01N33/6893 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60 ,  G01T1/00 ,  G01T1/02

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US11467161B2

公开(公告)日：2022-10-11

申请号：US15386346

申请日：2016-12-21

Applicant: Meso Scale Technologies, LLC.

Inventor： Simone Barbero ,  Eli N. Glezer ,  Anu Mathew ,  Mingyue Wang

IPC: G01N33/574 ,  A61K31/44 ,  A61K31/404 ,  C12Q1/48

Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US20200057070A1

公开(公告)日：2020-02-20

申请号：US16653268

申请日：2019-10-15

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Anu Mathew ,  Martin Stengelin ,  Mingyue Wang

IPC: G01N33/574

Abstract: The present invention relates to methods of diagnosing a liver disorder in a patient, as well as methods of monitoring the progression of a liver disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a chemotherapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US20180088108A1

公开(公告)日：2018-03-29

申请号：US15813411

申请日：2017-11-15

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Anu Mathew

IPC: G01N33/543 ,  G01N33/574

CPC classification number: G01N33/543 ,  G01N33/57438 ,  G01N2800/52

Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US20170242012A1

公开(公告)日：2017-08-24

申请号：US15488743

申请日：2017-04-17

Applicant: Meso Scale Technologies, LLC.

Inventor： Simone Barbero ,  Eli N. Glezer ,  Anu Mathew

IPC: G01N33/574 ,  A61K31/5377

CPC classification number: G01N33/57415 ,  A61K31/5377 ,  C12Q1/42 ,  C12Q1/485 ,  G01N2333/912 ,  G01N2333/916 ,  G01N2800/52

Abstract: The present invention relates to methods of diagnosing breast cancer in a patient, as well as methods of monitoring the progression of breast cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US11600373B2

公开(公告)日：2023-03-07

申请号：US16555271

申请日：2019-08-29

Applicant: MESO SCALE TECHNOLOGIES, LLC ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

Inventor： William F. Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC: G01N33/566 ,  G01N33/569 ,  G01N33/68 ,  G16H20/40 ,  G01T1/02 ,  G01T1/00 ,  G01N27/327 ,  G01N35/00

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

公开(公告)号：US20210364505A1

公开(公告)日：2021-11-25

申请号：US17394512

申请日：2021-08-05

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Anu Mathew

IPC: G01N33/543 ,  G01N33/574

Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US20140315742A1

公开(公告)日：2014-10-23

申请号：US14348275

申请日：2012-09-28

Applicant: MESO SCALE TECHNOLOGIES, LLC ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

Inventor： William F Blakely ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Anu Mathew ,  Natalia I. Ossetrova ,  George Sigal

IPC: G01N33/566

CPC classification number: G01N33/56972 ,  G01N33/566 ,  G01N33/6893 ,  G01N2333/70535 ,  G01N2333/70578 ,  G01N2800/40 ,  G01N2800/60 ,  G01T1/00 ,  G01T1/02

Abstract: The present invention relates to methods and kits to assess an absorbed dose of ionizing radiation and/or the severity of tissue injury from radiation in a patient. The invention also relates to algorithms used to calculate an absorbed dose of radiation based on biomarker measurements of a plurality of biomarkers that are altered relative to a normal control in the event of radiation exposure.

Abstract translation: 本发明涉及用于评估电离辐射吸收剂量和/或患者辐射组织损伤严重程度的方法和试剂盒。 本发明还涉及用于基于在辐射暴露的情况下相对于正常对照改变的多个生物标志物的生物标志物测量来计算辐射的吸收剂量的算法。

公开(公告)号：US20140221368A1

公开(公告)日：2014-08-07

申请号：US14168629

申请日：2014-01-30

Applicant: Meso Scale Technologies, LLC

Inventor： Simone Barbero ,  Eli N. Glezer ,  Anu Mathew

IPC: G01N33/574 ,  A61K31/5377

CPC classification number: G01N33/57415 ,  A61K31/5377 ,  C12Q1/42 ,  C12Q1/485 ,  G01N2333/912 ,  G01N2333/916 ,  G01N2800/52

Abstract: The present invention relates to methods of diagnosing breast cancer in a patient, as well as methods of monitoring the progression of breast cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

Abstract translation: 本发明涉及诊断患者乳腺癌的方法，以及监测乳腺癌进展的方法和/或监测治疗剂或治疗方案治疗方案的方法。 本发明还涉及结合本文所述的诊断方法使用的测定方法。