公开(公告)号：US20170283411A1

公开(公告)日：2017-10-05

申请号：US15513635

申请日：2015-09-18

Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATION

Inventor： Masakatsu SHIBASAKI ,  Naoya KUMAGAI ,  Liang YIN

IPC: C07D471/04 ,  B01J31/24

CPC classification number: C07D471/04 ,  B01J31/22 ,  B01J31/2409 ,  B01J2231/50 ,  B01J2531/16 ,  C07B53/00 ,  C07B57/00 ,  C07B61/00 ,  C07B2200/07 ,  C07C269/06 ,  C07C271/22 ,  C07D213/75

Abstract: A method for producing an optically active α-trifluoromethyl-β-amino acid derivative, the method including: allowing a compound represented by the following General Formula (1) and a compound represented by the following General Formula (2) to react in the presence of a copper-optically active phosphine complex obtained from a copper compound and an optically active phosphine compound, to thereby obtain an optically active α-trifluoromethyl-β-amino acid derivative represented by the following General Formula (3):

公开(公告)号：US20160145278A1

公开(公告)日：2016-05-26

申请号：US14900696

申请日：2013-10-08

Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATION

Inventor： Masakatsu SHIBASAKI ,  Naoya KUMAGAI ,  Liang YIN ,  Youmei BAO

IPC: C07F9/40 ,  B01J31/24 ,  C07F9/50

CPC classification number: C07F9/4062 ,  B01J31/24 ,  B01J2231/34 ,  B01J2531/16 ,  C07F9/36 ,  C07F9/4009 ,  C07F9/4015 ,  C07F9/4056 ,  C07F9/5054 ,  C07F9/65683

Abstract: A method for producing a compound represented by General Formula (1), the method including: reacting a compound represented by General Formula (3) and a compound represented by General Formula (4): where R1 and R2 each represent aliphatic group which may have substituent, or aromatic group which may have substituent (with the proviso that R1 and R2 are different groups), R3 represents aromatic group which may have substituent, and R4 represents aliphatic group which may have substituent, or aromatic group which may have substituent, where R1 and R2 each represent aliphatic group which may have substituent, or aromatic group which may have substituent (with the proviso that R1 and R2 are different groups), and R3 represents aromatic group which may have substituent, where R4 represents aliphatic group which may have substituent, or aromatic group which may have substituent.

Abstract translation: 一种制备由通式（1）表示的化合物的方法，所述方法包括：使通式（3）表示的化合物与通式（4）表示的化合物反应：其中R 1和R 2各自表示可具有 取代基或可以具有取代基的芳香族基团（前提条件是R 1和R 2是不同的基团），R 3表示可以具有取代基的芳香族基团，R 4表示可以具有取代基的脂肪族基团，或者可以具有取代基的芳香族基团， R 1和R 2各自表示可以具有取代基的脂肪族基团或可以具有取代基的芳香族基团（前提条件是R 1和R 2是不同的基团），R 3表示可以具有取代基的芳香族基团，其中R 4表示可以具有取代基的脂族基团 取代基或可具有取代基的芳基。