公开(公告)号：US20170291879A1

公开(公告)日：2017-10-12

申请号：US15511859

申请日：2015-09-07

Applicant: Microbial Chemistry Research Foundation ,  Gakubunkan ,  Microbial Chemistry Research Foundation

Inventor： Sonoko Atsumi ,  Masabumi Shibuya ,  Shun-ichi Ohba ,  Tomoyuki Kimura ,  Yoshihiko Kobayashi ,  Hayamitsu Adachi ,  Chisato Nosaka ,  Akio Nomoto

IPC: C07D241/44 ,  G01N33/50

CPC classification number: C07D241/44 ,  A61K31/498 ,  C12Q1/02 ,  G01N33/5011 ,  G01N2333/71

Abstract: A cancer cell proliferation inhibitor including at least one selected from compounds represented by Structural Formulae (1) to (8), wherein the cancer cell is at least one of a cancer cell overexpressing a wild-type epidermal growth factor receptor and a cancer cell expressing an epidermal growth factor receptor mutant vIII.

公开(公告)号：US10202347B2

公开(公告)日：2019-02-12

申请号：US15817090

申请日：2017-11-17

Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATION

Inventor： Manabu Kawada ,  Hikaru Abe ,  Takumi Watanabe ,  Hiroyuki Inoue ,  Shun-ichi Ohba ,  Chigusa Hayashi ,  Masayuki Igarashi

IPC: C07D215/233 ,  A61P31/04 ,  A61P35/00

Abstract: The present application provides novel compounds having anti-cancer or anti-Helicobacter pylori activity, pharmaceutical compositions and method for producing and using the novel compound.

公开(公告)号：US20180345260A1

公开(公告)日：2018-12-06

申请号：US15778376

申请日：2016-11-21

Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATION

Inventor： Masakatsu SHIBASAKI ,  Naoya KUMAGAI ,  Akihito NONOYAMA ,  Kazuki HASHIMOTO ,  Akira SAITO

IPC: B01J31/22 ,  B01J37/04 ,  C07C201/12 ,  C07C205/16 ,  C07C205/54 ,  C07C237/04

CPC classification number: B01J31/22 ,  B01J37/04 ,  B01J2231/341 ,  B01J2531/004 ,  B01J2531/12 ,  B01J2531/38 ,  C07B61/00 ,  C07C201/12 ,  C07C205/16 ,  C07C205/32 ,  C07C205/54 ,  C07C237/04 ,  C07C237/22 ,  C07F7/003

Abstract: A catalyst including: neodymium; sodium; and a ligand, which is a compound expressed by Structural Formula (1) below, wherein the neodymium and the ligand form a complex at a molar ratio of 1:2 (neodymium:ligand):

公开(公告)号：US09839648B2

公开(公告)日：2017-12-12

申请号：US14895719

申请日：2014-06-03

Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATION ,  COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Yoshimasa Ishizaki ,  Masayuki Igarashi ,  Patrick Joseph Brennan ,  Dean Calvin Crick

IPC: A61K31/7052 ,  C07H19/067 ,  A61K31/7072 ,  A61K45/06 ,  C12Q1/04 ,  A61K31/496 ,  C12Q1/18

CPC classification number: A61K31/7072 ,  A61K31/496 ,  A61K31/551 ,  A61K31/7052 ,  A61K45/06 ,  C07H19/067 ,  C12Q1/04 ,  C12Q1/18 ,  A61K2300/00

Abstract: A drug combination against acid-fast bacillus, including: an inhibitor for WecA or an ortholog thereof; and at least one of an inhibitor for MurX or an ortholog thereof and an RNA synthesis inhibitor, wherein the inhibitor for WecA or an ortholog thereof is used in combination with the at least one of an inhibitor for MurX or an ortholog thereof and an RNA synthesis inhibitor; a screening method for a drug against acid-fast bacillus; and an inhibitor for WecA or an ortholog thereof.

公开(公告)号：US20150375219A1

公开(公告)日：2015-12-31

申请号：US14767620

申请日：2014-02-07

Applicant: Microbial Chemistry Research Foundation

Inventor： Masakatsu SHIBASAKI ,  Naoya KUMAGAI ,  Takanori OGAWA

IPC: B01J31/22 ,  C07C201/12

CPC classification number: B01J31/22 ,  B01J21/185 ,  B01J23/10 ,  B01J31/0212 ,  B01J31/0247 ,  B01J31/0252 ,  B01J31/0274 ,  B01J31/0275 ,  B01J31/2226 ,  B01J2231/30 ,  B01J2231/342 ,  B01J2531/0275 ,  B01J2531/12 ,  B01J2531/57 ,  B01J2540/22 ,  C07B2200/07 ,  C07C201/12 ,  C07C205/02 ,  C07C237/22 ,  C07C205/26 ,  C07C205/15 ,  C07C205/31

Abstract: A catalyst, which is obtained by mixing a compound expressed by the following Structural Formula (1), a nitroalkane compound, a neodymium-containing compound, a sodium-containing compound, and a carbon structure:

Abstract translation: 通过将由以下结构式（1）表示的化合物，硝基烷烃化合物，含钕化合物，含钠化合物和碳结构混合得到的催化剂：

公开(公告)号：US09079229B2

公开(公告)日：2015-07-14

申请号：US13828078

申请日：2013-03-14

Applicant: Microbial Chemistry Research Foundation

Inventor： Hiroyasu Doi

IPC: C02F3/34 ,  C12N9/54 ,  B09B3/00 ,  C12R1/125 ,  B09B5/00

CPC classification number: B09B3/00 ,  B09B5/00 ,  C02F3/341 ,  C02F3/342 ,  C12N9/54 ,  C12R1/125 ,  C12Y304/21062 ,  Y02W10/37

Abstract: A microorganism belonging to the genus Bacillus, wherein the microorganism belonging to the genus Bacillus is any one of a Bacillus subtilis 104-1-3-1 strain (Accession No: NITE BP-680) and a derivative strain thereof, and wherein the microorganism belonging to the genus Bacillus produces a thrombolytic enzyme which decomposes waste.

Abstract translation: 属于芽孢杆菌属的微生物，其中属于芽孢杆菌属的微生物是枯草芽孢杆菌104-1-3-1菌株（保藏号：NITE BP-680）及其衍生菌株中的任一种，其中微生物 属于芽孢杆菌属的芽孢杆菌产生分解废物的血栓溶解酶。

公开(公告)号：US20140335595A1

公开(公告)日：2014-11-13

申请号：US14296511

申请日：2014-06-05

Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATION

Inventor： Hiroyasu DOI ,  Naoko KINOSHITA ,  Tatsuzo OKA ,  Zhao HUI

IPC: C12N9/52

CPC classification number: C12N9/52 ,  C12R1/465

Abstract: The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a protease produced by such microorganisms and capable of decomposing proteins recalcitrant to proteolysis, and a method of utilizing the same. The novel culture is of a soil-derived microorganism belonging to Streptomyces sp., or a strain derived therefrom, which produces a protease capable of efficiently decomposing proteins recalcitrant to proteolysis as contained in waste water, organic waste liquids, industrial wastes and so forth.

Abstract translation: 本发明提供了蛋白酶活性高的微生物纯生物培养物，能够分解垃圾，废水，有机废液，工业废物等中含有的蛋白质水解蛋白质，这些微生物产生的能够分解蛋白质的蛋白质 难以进行蛋白水解，以及使用该方法。 新型培养物是属于链霉菌属（Streptomyces sp。）的土壤衍生微生物或其衍生菌株，其产生能够有效分解废水，有机废液，工业废物等中所含的蛋白酶解蛋白质的蛋白酶。

公开(公告)号：US20140256923A1

公开(公告)日：2014-09-11

申请号：US14264361

申请日：2014-04-29

Applicant: Microbial Chemistry Research Foundation

Inventor： Koichi NAKAE ,  Fukiko KOJIMA

IPC: C07H15/22 ,  C12P19/48

CPC classification number: C07H15/22 ,  C07H15/20 ,  C12P17/06 ,  C12P19/48 ,  C12R1/01

Abstract: A compound represented by the following Structural Formula (A) or a salt thereof. The compound or the salt thereof is suitably produced from a microorganism belonging to the genus Saccharothrix and can be suitably used as a prostaglandin production inhibitor.

Abstract translation: 由以下结构式（A）表示的化合物或其盐。 化合物或其盐适宜地由属于蔗糖属属的微生物产生，可以适当地用作前列腺素产生抑制剂。

公开(公告)号：US20250002954A1

公开(公告)日：2025-01-02

申请号：US18689154

申请日：2022-08-24

Applicant: Microbial Chemistry Research Foundation

Inventor： Shun-ichi Wada ,  Honami Arimura ,  Masayuki Igarashi ,  Miho Nagayoshi ,  Shun-ichi Ohba ,  Ryuichi Sawa ,  Yumiko Kubota

IPC: C12P17/16 ,  C12N1/20 ,  C12P19/26 ,  C12R1/465

Abstract: Provided are a protective agent, a surfactant composition, a composition for blood glucose level control, an autophagy inducer, a mycobacterium stain, or a protein extractant characterized by containing compounds represented by general formula (1).

公开(公告)号：US11135234B2

公开(公告)日：2021-10-05

申请号：US16749191

申请日：2020-01-22

Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATION ,  MEIJI SEIKA PHARMA CO., LTD.

Inventor： Yoshiaki Takahashi ,  Eijiro Umemura ,  Takashi Ida ,  Masayuki Igarashi

IPC: A61K31/7036 ,  C07H15/224 ,  A61P31/04

Abstract: A compound represented by the following general formula (I) or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutical composition thereof, and the use thereof to prevent or treat infectious diseases and a method to prevent or treat infectious diseases using those regimen are disclosed. The compound represented by formula (I) has an antibacterial activity against both gram-positive and gram-negative bacteria, and is useful in the prevention or treatment of infectious diseases caused by these bacteria.