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公开(公告)号：US20150076341A1
公开(公告)日：2015-03-19
申请号：US14551397
申请日：2014-11-24
Applicant: MICROMASS UK LIMITED
Inventor： Emmanuelle Claude , Mark Williams Towers , Kieran Neeson , Richard Denny , Jeffrey M. Brown , Paul R. Murray , Mark McDowall
CPC classification number: H01J49/0031 , G01N27/622 , H01J49/0027 , H01J49/0036 , H01J49/004 , H01J49/005 , H01J49/26 , H01J49/40 , H01J49/446 , H01J2237/05
Abstract: The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas.
Abstract translation: 本发明涉及一种质谱法，一种适于执行该方法的设备和一种质谱仪。 更具体地但非唯一地，本发明涉及一种质谱方法，其包括通过测量来自样品的两个或多个不同区域的亲和和离子离子并鉴定样品中的变化的步骤，从样品中分离亲本和断裂离子 样品中区域之间的亲本离子数，以及两个区域之间的分离离子数量的相应变化。
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公开(公告)号：US20130277548A1
公开(公告)日：2013-10-24
申请号：US13851731
申请日：2013-03-27
Applicant: Micromass UK Limited
Inventor： Emmanuelle Claude , Mark W. Towers , Kieran Neeson , Richard Denny , Jeffery M. Brown , Paul Murray , Mark McDowall
CPC classification number: H01J49/0031 , G01N27/622 , H01J49/0027 , H01J49/0036 , H01J49/004 , H01J49/005 , H01J49/26 , H01J49/40 , H01J49/446 , H01J2237/05
Abstract: The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas.
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公开(公告)号：US10153145B2
公开(公告)日：2018-12-11
申请号：US15477800
申请日：2017-04-03
Applicant: Micromass UK Limited
Inventor： Emmanuelle Claude , Mark Williams Towers , Kieran Neeson , Richard Denny , Jeffrey M. Brown , Paul R. Murray , Mark McDowall
Abstract: The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas.
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Patent Agency Ranking
公开(公告)号：US08895917B2
公开(公告)日：2014-11-25
申请号：US13851731
申请日：2013-03-27
Applicant: Micromass UK Limited
Inventor： Emmanuelle Claude , Mark W. Towers , Kieran Neeson , Richard Denny , Jeffery M. Brown , Paul Murray , Mark McDowall
Abstract: The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas.
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公开(公告)号：US20170207072A1
公开(公告)日：2017-07-20
申请号：US15477800
申请日：2017-04-03
Applicant: Micromass UK Limited
Inventor： Emmanuelle Claude , Mark Williams Towers , Kieran Neeson , Richard Denny , Jeffrey M. Brown , Paul R. Murray , Mark McDowall
CPC classification number: H01J49/0031 , G01N27/622 , H01J49/0027 , H01J49/0036 , H01J49/004 , H01J49/005 , H01J49/26 , H01J49/40 , H01J49/446 , H01J2237/05
Abstract: The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas.
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公开(公告)号：US09613785B2
公开(公告)日：2017-04-04
申请号：US14551397
申请日：2014-11-24
Applicant: Micromass UK Limited
Inventor： Emmanuelle Claude , Mark Williams Towers , Kieran Neeson , Richard Denny , Jeffrey M. Brown , Paul R. Murray , Mark McDowall
CPC classification number: H01J49/0031 , G01N27/622 , H01J49/0027 , H01J49/0036 , H01J49/004 , H01J49/005 , H01J49/26 , H01J49/40 , H01J49/446 , H01J2237/05
Abstract: The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas.
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公开(公告)号：US09048072B2
公开(公告)日：2015-06-02
申请号：US13851731
申请日：2013-03-27
Applicant: Micromass UK Limited
Inventor： Emmanuelle Claude , Mark W. Towers , Kieran Neeson , Richard Denny , Jeffery M. Brown , Paul Murray , Mark McDowall
CPC classification number: H01J49/0031 , G01N27/622 , H01J49/0027 , H01J49/0036 , H01J49/004 , H01J49/005 , H01J49/26 , H01J49/40 , H01J49/446 , H01J2237/05
Abstract: The present invention relates to a method of mass spectrometry, an apparatus adapted to perform the method and a mass spectrometer. More particularly, but not exclusively, the present invention relates to a method of mass spectrometry comprising the step of associating parent and fragmentation ions from a sample by measuring the parent and fragmentation ions from two or more different areas of the sample and identifying changes in the number of parent ions between the areas in the sample, and corresponding changes in the number of fragmentation ions between the two areas.
Abstract translation: 本发明涉及一种质谱法，一种适于执行该方法的设备和一种质谱仪。 更具体地但非唯一地，本发明涉及一种质谱方法，其包括通过测量来自样品的两个或多个不同区域的亲和和离子离子并鉴定样品中的变化的步骤，从样品中分离亲本和断裂离子 样品中区域之间的亲本离子数，以及两个区域之间的分离离子数量的相应变化。
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8.发明申请METHOD FOR THE INVESTIGATION OF DIFFERENCES IN ANALYTICAL DATA AND AN APPARATUS ADAPTED TO PERFORM SUCH A METHOD 审中-公开用于分析数据中的差异的调查方法和适合于执行这种方法的装置公开(公告)号：US20150120212A1
公开(公告)日：2015-04-30
申请号：US14388911
申请日：2013-03-28
Applicant: Micromass UK Limited
Inventor： Richard Denny , Kieran Neeson
CPC classification number: G01N33/0004 , G01N30/00 , H01J49/0036
Abstract: A method of investigating differences in data produced by at least one analytical instrument comprising providing a first data set from a first sample in a plurality of data bins; providing a second data set from a second sample in a plurality of data bins; providing a data model of said data sets in which the data in a plurality of data bins from the first data set is linked to the data in the corresponding bins of the second data set, each linked pair having an associated switch parameter linking the two together; and, exploring the posterior probability distribution for the data model as a function of the switch parameters to produce a posterior probability distribution map.
Abstract translation: 一种调查由至少一个分析仪器产生的数据差异的方法，包括从多个数据箱中的第一样本提供第一数据集; 从多个数据仓中的第二样本提供第二数据集; 提供所述数据集合的数据模型，其中来自第一数据集的多个数据仓中的数据被链接到第二数据集的相应仓中的数据，每个链接对具有将两者连接在一起的相关联的切换参数 ; 并且探索数据模型的后验概率分布作为切换参数的函数以产生后验概率分布图。
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