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公开(公告)号:US20220227728A1
公开(公告)日:2022-07-21
申请号:US17152344
申请日:2021-01-19
申请人: MING-HSIN LI , KAI-HUNG CHENG , SHENG-NAN LO , SHIH-WEI LO , YUAN-RUEI HUANG , JENN-TZONG CHEN
发明人: MING-HSIN LI , KAI-HUNG CHENG , SHENG-NAN LO , SHIH-WEI LO , YUAN-RUEI HUANG , JENN-TZONG CHEN
IPC分类号: C07D401/04 , A61K51/04
摘要: The present invention discloses a series of nuclear medicine tracers that are combined with brain microtubule-associated protein Tau targeting compounds to produce a group of compounds of nuclear medicine that can be utilized for imaging of microtubule-associated protein Tau. When the positrons released by the decay encounter the electrons of the cells in the sample, utilizing the positron decay characteristics of fluorine-18 or iodine-124 isotope to generate mutual destruction reactions, a pair of opposite gamma rays is formed which are imaged by positron emission tomography. The compounds can be applied for the in vivo detection of microtubule-associated protein Tau deposits in the brain. The invention provides a strategy for diagnosis of Alzheimer's disease and a method to measure the efficacy of therapeutic drugs targeting microtubule-associated protein Tau.
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公开(公告)号:US20220089574A1
公开(公告)日:2022-03-24
申请号:US17027748
申请日:2020-09-22
申请人: MING-HSIN LI , SHENG-NAN LO , SHIH-WEI LO , SHIH-YING LEE , SU-JUNG CHEN , WEI-LIN LO , MING-WEI CHEN , YUAN-RUEI HUANG
发明人: MING-HSIN LI , SHENG-NAN LO , SHIH-WEI LO , SHIH-YING LEE , SU-JUNG CHEN , WEI-LIN LO , MING-WEI CHEN , YUAN-RUEI HUANG
IPC分类号: C07D403/12 , C07F5/00
摘要: The structure and preparation method of a compound D-L2(-B)-L1-A is disclosed, A is a physiologically and pharmacologically active molecule that physically binds to a specific biological molecule or receptor; L1 is a variable structure with the molecular connection activity at both ends connecting to A and L2; L2 is a variable structure, which has three-terminal molecular connection activity connecting to L1, D and B; B is a physiologically and pharmacologically active molecule that binds to albumin, changing the A molecule in the body cyclic characteristics; D is a polycarboxylic macrocyclic structure that binds to radioisotopes; D-L2(-B)-L1-A compound can be used to express chemokine receptor 4 (CXCR4) receptors on cells, tissues, and/or organs, and after binding with radionuclides, it is suitable for detection of CXCR4 protein binding in vitro, detection of CXCR4 cell binding in vitro or detection of CXCR4 expression in in vivo animal imaging.
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公开(公告)号:US20210121074A1
公开(公告)日:2021-04-29
申请号:US16664946
申请日:2019-10-28
申请人: MING-HSIN LI , KAI-HUNG CHENG , SHIH-WEI LO
发明人: MING-HSIN LI , KAI-HUNG CHENG , SHIH-WEI LO
IPC分类号: A61B5/0205 , A61B5/029 , A61B5/0476 , A61B5/00
摘要: A system and method for monitoring cardiovascular and brain functions in combination with a physiological detection device, which uses a smart wearable device to detect physiological data such as heart rate and pulse pressure of a user, and transmits the physiological data to an arithmetic function. An electronic device in which a preset function and a calculation formula are built in, and the physiological data can be converted into corresponding determination parameters to monitor the possibility and risk of cardiovascular diseases and neurodegenerative diseases.
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