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1.
公开(公告)号:US20220227728A1
公开(公告)日:2022-07-21
申请号:US17152344
申请日:2021-01-19
申请人: MING-HSIN LI , KAI-HUNG CHENG , SHENG-NAN LO , SHIH-WEI LO , YUAN-RUEI HUANG , JENN-TZONG CHEN
发明人: MING-HSIN LI , KAI-HUNG CHENG , SHENG-NAN LO , SHIH-WEI LO , YUAN-RUEI HUANG , JENN-TZONG CHEN
IPC分类号: C07D401/04 , A61K51/04
摘要: The present invention discloses a series of nuclear medicine tracers that are combined with brain microtubule-associated protein Tau targeting compounds to produce a group of compounds of nuclear medicine that can be utilized for imaging of microtubule-associated protein Tau. When the positrons released by the decay encounter the electrons of the cells in the sample, utilizing the positron decay characteristics of fluorine-18 or iodine-124 isotope to generate mutual destruction reactions, a pair of opposite gamma rays is formed which are imaged by positron emission tomography. The compounds can be applied for the in vivo detection of microtubule-associated protein Tau deposits in the brain. The invention provides a strategy for diagnosis of Alzheimer's disease and a method to measure the efficacy of therapeutic drugs targeting microtubule-associated protein Tau.
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公开(公告)号:US20210121074A1
公开(公告)日:2021-04-29
申请号:US16664946
申请日:2019-10-28
申请人: MING-HSIN LI , KAI-HUNG CHENG , SHIH-WEI LO
发明人: MING-HSIN LI , KAI-HUNG CHENG , SHIH-WEI LO
IPC分类号: A61B5/0205 , A61B5/029 , A61B5/0476 , A61B5/00
摘要: A system and method for monitoring cardiovascular and brain functions in combination with a physiological detection device, which uses a smart wearable device to detect physiological data such as heart rate and pulse pressure of a user, and transmits the physiological data to an arithmetic function. An electronic device in which a preset function and a calculation formula are built in, and the physiological data can be converted into corresponding determination parameters to monitor the possibility and risk of cardiovascular diseases and neurodegenerative diseases.
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