公开(公告)号：US20220227728A1

公开(公告)日：2022-07-21

申请号：US17152344

申请日：2021-01-19

申请人： MING-HSIN LI ,  KAI-HUNG CHENG ,  SHENG-NAN LO ,  SHIH-WEI LO ,  YUAN-RUEI HUANG ,  JENN-TZONG CHEN

发明人： MING-HSIN LI ,  KAI-HUNG CHENG ,  SHENG-NAN LO ,  SHIH-WEI LO ,  YUAN-RUEI HUANG ,  JENN-TZONG CHEN

IPC分类号： C07D401/04 ,  A61K51/04

摘要： The present invention discloses a series of nuclear medicine tracers that are combined with brain microtubule-associated protein Tau targeting compounds to produce a group of compounds of nuclear medicine that can be utilized for imaging of microtubule-associated protein Tau. When the positrons released by the decay encounter the electrons of the cells in the sample, utilizing the positron decay characteristics of fluorine-18 or iodine-124 isotope to generate mutual destruction reactions, a pair of opposite gamma rays is formed which are imaged by positron emission tomography. The compounds can be applied for the in vivo detection of microtubule-associated protein Tau deposits in the brain. The invention provides a strategy for diagnosis of Alzheimer's disease and a method to measure the efficacy of therapeutic drugs targeting microtubule-associated protein Tau.

公开(公告)号：US11077217B2

公开(公告)日：2021-08-03

申请号：US16215647

申请日：2018-12-11

申请人： Ming-Hsin Li ,  Su-Jung Chen ,  Ming-Wei Chen ,  Yuan-Ruei Huang ,  Shih-Ying Lee ,  Chun-Fang Feng ,  Sheng-Nan Lo ,  Chih-Hsien Chang

发明人： Ming-Hsin Li ,  Su-Jung Chen ,  Ming-Wei Chen ,  Yuan-Ruei Huang ,  Shih-Ying Lee ,  Chun-Fang Feng ,  Sheng-Nan Lo ,  Chih-Hsien Chang

IPC分类号： A61K51/08 ,  A61K51/04 ,  A61K51/06

摘要： The present invention provides a radioactive labeling method for neuropeptide Y (NPY) compound and a mammalian diagnostic radioactive targeting medicine with NPY peptide being modified at position 27th to 36th, and after binding with the chelating agent and labeling the radiation nucleus 66Ga67Ga68Ga177Lu or 111In to provide a radioactive targeting medicine for multi-type breast cancer diagnosis and treatment.

公开(公告)号：US20150010447A1

公开(公告)日：2015-01-08

申请号：US13936219

申请日：2013-07-08

申请人： Ming-Hsin Li ,  Hsin-Han Hsieh

发明人： Ming-Hsin Li ,  Hsin-Han Hsieh

IPC分类号： C22B58/00

CPC分类号： C22B58/00 ,  C22B3/0004 ,  Y02P10/234

摘要： A method of purification for recycling of gallium-69 isotopes includes processes of proton irradiation and dissolution for a silver alloy plating target with gallium-69. After the proton irradiation and dissolution, a high concentration elution liquid of gallium-69 and germanium-68 is obtained by washing through an ion-exchange resin to filter out gallium-69 solution, followed by neutralizing precipitation, drying, and sintering treatments to obtain a gallium oxide. The gallium oxide can be dissolved to produce a solid target, and the washing processes can be repeated. The solid target after use can be placed in recycling again. This method is not only implemented to reduce the cost of production and comply with recycling notion nowadays, but also enhance efficiency in the practical application of radioisotopes.

公开(公告)号：US08239159B2

公开(公告)日：2012-08-07

申请号：US12569908

申请日：2009-09-30

申请人： Ming-Hsin Li ,  Ting Shien Duh ,  Wuu-Jyn Lin

发明人： Ming-Hsin Li ,  Ting Shien Duh ,  Wuu-Jyn Lin

IPC分类号： G06F15/00

CPC分类号： G21G1/10 ,  G21G2001/0094

摘要： A method used to yield irradiation product with minimal impurity for the solid target for gallium (Ga)-68/germanium (Ge)-68 generator mainly consists of the procedures: first calculate the thickness d for the electroplated gallium (Ga)-69 on the solid target; and then through a graph of decay curves including 69Ga(p, 2n) 68Ge target thickness and incident energy with 5 different incident energy doses, derive the corresponding irradiation energy dose Yi for each group after decay; and through the graph including 69Ga(p,2n)68Ge incident energy and reaction cross-sectional area, derive the nuclear reaction cross-sectional area for each group for germanium(Ge)-68, gallium (Ga)-68, zinc (Zn)-65 and figure out the mean reaction area (MRA) from the reaction cross-sectional area of each group; and select the maximum germanium(Ge)-68 MRA value and the minimum gallium (Ga)-68 and zinc (Zn)-65 MRA values; and generate the required default irradiation energy for the MRA of each group.

摘要翻译： 用于产生镓（Ga）-68 /锗（Ge）-68发生器的固体靶的杂质最小的辐射产物的方法主要包括以下步骤：首先计算电镀镓（Ga）-69的厚度d 坚实的目标; 然后通过包括69 Ga（p，2n）68Ge目标厚度和入射能量与5个不同入射能量剂量的衰减曲线图，得出每个组在衰变后的相应的照射能量剂量Yi; 通过包括69Ga（p，2n）68Ge入射能和反应截面积的图，得出锗（Ge）-68，镓（Ga）-68，锌（Zn）的每个组的核反应截面积 ）-65，计算每组反应截面积的平均反应面积（MRA）; 并选择最大锗（Ge）-68 MRA值和最小镓（Ga）-68和锌（Zn）-65 MRA值; 并为每组的MRA产生所需的默认照射能量。

公开(公告)号：US20110041950A1

公开(公告)日：2011-02-24

申请号：US12543507

申请日：2009-08-19

申请人： Ming-Hsin Li

发明人： Ming-Hsin Li

IPC分类号： B67C3/02

CPC分类号： B65B3/003

摘要： An automatic radiopharmaceuticals filling machine mainly comprises a main unit with an activation mechanism to perform three-dimensional reciprocal movement. The activation mechanism has a lateral slider that can be activated to move reciprocally along lateral X-axis. On the lateral slider, there is a vertical slider that can extend perpendicularly and move reciprocally along lateral Y-axis. An injection needle is located on the vertical slider and can be activated to move reciprocally along Z-axis perpendicular to the lateral slider. A syringe rack is located in the moving range of the injection needle to accommodate a plural number of syringes, on each of which there is an injection hole. A drug pump has an inlet and an outlet. The inlet connects to a high-dose radiopharmaceuticals drug bottle. The outlet connects to the injection needle. The drug pump withdraws the radiopharmaceuticals from the drug bottle to the injection needle and allows the front end of the injection needle activated to go through the injection hole into the syringe and fill the radiopharmaceuticals into the syringe.

摘要翻译： 一种自动放射性药物灌装机主要包括具有执行三维往复运动的激活机构的主单元。 激活机构具有可以被激活以沿着横向X轴往复运动的横向滑块。 在横向滑动器上，有一个垂直滑动件可以垂直延伸并沿横向Y轴往复运动。 注射针位于垂直滑块上，可以被激活以沿着与轴向滑动件垂直的Z轴往复运动。 注射器架位于注射针的移动范围内，以容纳多个注射器，每个注射器都具有注射孔。 药泵具有入口和出口。 入口连接到高剂量放射性药物药瓶。 出口连接到注射针。 药物泵将放射性药物从药瓶抽出到注射针上，并且允许注射针的前端被激活以通过注射孔进入注射器并将放射性药物填充到注射器中。

公开(公告)号：US20100310428A1

公开(公告)日：2010-12-09

申请号：US12478787

申请日：2009-06-05

申请人： MING-HSIN LI ,  HSIN-EII WANG ,  CHUN-YI WU ,  WUU-JYH LIN

发明人： MING-HSIN LI ,  HSIN-EII WANG ,  CHUN-YI WU ,  WUU-JYH LIN

IPC分类号： G05D16/00 ,  B01J19/00 ,  G05B11/00

CPC分类号： B01J19/004

摘要： An automatic synthesis device for fluorine-18-ACETATE ([18F]fluoroacetate) consists of a machinery housing that has multiple reactors and multiple raw material containers, and uses multiple control valves between each reactor and container, and operates the control valves through a control system to charge the raw material from each container to each reactor in an automatic and sequential fashion to execute the six procedures: fluorination, azeotropic dewatering, synthesis (reaction with precursors), purification and separation, hydrolysis and neutralization, purification and collection. The operation simply requires adding raw materials to the containers in advance, turning on power, charging reactive gases. In 50 minutes, the process to produce the product will be completed. The operation is really simple and can effectively improve production efficiency.

摘要翻译： 用于氟-18-乙酸酯（[18 F]氟乙酸酯）的自动合成装置由具有多个反应器和多个原料容器的机械壳体组成，并且在每个反应器和容器之间使用多个控制阀，并通过控制器操作控制阀 系统，以自动和连续的方式从每个容器向每个反应器充填原料，以执行氟化，共沸脱水，合成（与前体反应），纯化和分离，水解和中和，纯化和收集的六个步骤。 该操作只需要事先向容器中加入原料，打开电源，充入反应气体。 50分钟内，生产产品的过程即将完成。 操作非常简单，可以有效提高生产效率。

公开(公告)号：US20070062865A1

公开(公告)日：2007-03-22

申请号：US11601693

申请日：2006-11-20

申请人： Heng-Chuan Wang ,  Ming-Hsin Li ,  Hsu-Wen Tsang ,  Mei-Mao Wu ,  Hsui-Ping Lin

发明人： Heng-Chuan Wang ,  Ming-Hsin Li ,  Hsu-Wen Tsang ,  Mei-Mao Wu ,  Hsui-Ping Lin

IPC分类号： B01D69/02 ,  C12N1/20

CPC分类号： C02F1/5272 ,  C02F3/34 ,  C02F2209/06 ,  C12N1/20

摘要： The present invention relates to a novel flocculant comprising bacteria of the Bacillus genus cultivated in a culture medium comprising soybean protein, glucose, molasses, and yeast. Alternatively, the flocculant comprises soybean protein. The present invention also relates to methods of making the flocculant, including fermentation method for mass production, and methods of using the flocculant in water treatment.

摘要翻译： 本发明涉及包含在包含大豆蛋白，葡萄糖，糖蜜和酵母的培养基中培养的芽孢杆菌属细菌的新型絮凝剂。 或者，絮凝剂包括大豆蛋白。 本发明还涉及制备絮凝剂的方法，包括大规模生产的发酵方法，以及在水处理中使用絮凝剂的方法。

公开(公告)号：US6162686A

公开(公告)日：2000-12-19

申请号：US156362

申请日：1998-09-18

申请人： Kuo Ching Huang ,  Tse-Liang Ying ,  Yu-Hua Lee ,  Ming-Hsin Li

发明人： Kuo Ching Huang ,  Tse-Liang Ying ,  Yu-Hua Lee ,  Ming-Hsin Li

IPC分类号： H01L23/525 ,  H01L21/336 ,  H01L21/00 ,  H01L21/331 ,  H01L21/44 ,  H01L21/82

CPC分类号： H01L23/5258 ,  H01L2924/0002 ,  H01L2924/00

摘要： A method of forming a grooved fuse (plug fuse) in the same step that via plugs are formed in the guard ring area 14 and in product device areas. A key point of the invention is to form fuses from the via plug layer, not from the metal layers. Also, key guard rings are formed around the plug guise. The invention can include the following: a semiconductor structure is provided having a fuse area, a guard ring area surrounding the fuse area; and a device area. First and second conductive strips are formed. First and second insulating layers are formed over the first and second conductive strips. Plug contacts and fuse plugs are formed through the first and second insulating layers to the first and second conductive strips. A third insulating layer is formed over the second insulating layer. Metal lines are formed over the third insulating layer in the device area. A fuse via opening is formed in the third insulating layer. A plug fuse is formed in the fuse via opening. A fourth insulating layer is formed over the plug fuse and the third insulating layer. A fuse opening is formed at least partially though the fourth insulating layer over the fuse area.

摘要翻译： 在通过塞子形成在保护环区域14和产品装置区域中的相同步骤中形成带槽保险丝（插头保险丝）的方法。 本发明的一个关键点是从通孔塞层而不是金属层形成保险丝。 此外，围绕插头形状形成关键保护环。 本发明可以包括：提供具有保险丝区域的半导体结构，围绕保险丝区域的保护环区域; 和设备区域。 形成第一和第二导电条。 第一和第二绝缘层形成在第一和第二导电条上。 插头触点和熔丝插头通过第一和第二绝缘层形成到第一和第二导电条。 在第二绝缘层上形成第三绝缘层。 金属线形成在器件区域中的第三绝缘层上。 在第三绝缘层中形成保险丝通孔。 保险丝通过开口形成插头保险丝。 在插头熔断器和第三绝缘层上形成第四绝缘层。 保险丝开口至少部分地通过保险丝区域上的第四绝缘层形成。

公开(公告)号：US09707521B2

公开(公告)日：2017-07-18

申请号：US13956375

申请日：2013-08-01

申请人： Ming-Hsin Li ,  Shu-Pei Chiu ,  Chih-Hsien Chang ,  Te-Wei Lee

发明人： Ming-Hsin Li ,  Shu-Pei Chiu ,  Chih-Hsien Chang ,  Te-Wei Lee

IPC分类号： B01D65/10 ,  G01M3/06

CPC分类号： B01D65/102 ,  B01D65/10 ,  G01M3/06

摘要： An automated test apparatus for risk and integrity testing for pharmaceutical filtration membranes, including at least the following components: a liquid injection inlet, a pump, a fluid pressure gauge, a gas pressure gauge, a plurality of solenoid valves, a plurality of membranes, a gas pressure regulator valve, a pharmaceutical product bottle, and a bubble generation bottle. The automated test apparatus of the present invention is controlled by computer software in connection with an automatic pharmaceutical synthesis apparatus for automated testing. In use of the automated test apparatus of the present invention, it needs only to start the operating system of the automated test apparatus for membrane risk and integrity test after the completion of the automatic pharmaceutical synthesis. The membrane risk and integrity test can be accomplished in a short time by measuring pressures of gas and liquid with pressure gauges deposed online concurrently.

公开(公告)号：US20160113884A1

公开(公告)日：2016-04-28

申请号：US14522583

申请日：2014-10-24

申请人： Wuu-Jyh Lin ,  Ting-Shien Duh ,  Wei-Ming Li ,  Ming-Hsin Li

发明人： Wuu-Jyh Lin ,  Ting-Shien Duh ,  Wei-Ming Li ,  Ming-Hsin Li

IPC分类号： A61K9/51 ,  A61K31/704

CPC分类号： A61K9/5146 ,  A61K9/5192 ,  A61K31/704

摘要： The preparation method of radiation-sensitive copolymer carrier for coating radiated nanoparticles and/or chemotherapy drugs includes forming a nanosphere by diselenide block copolymers and DSPE-PEG-biomarkers to coat chemotherapy drugs and/or radiated nanoparticles that can be released from the opened nanosphere by protons penetrating tissue during proton therapy. The treatment effect of proton therapy is enhanced by two ways of using the radiated nanoparticles released from an opened nanosphere to produce nuclear fission with the protons for releasing electrons to destroy cancer cells of tumor and the chemotherapy drugs released from the opened nanosphere for distributing among tissue to kill the cancer cells of the tumor.

摘要翻译： 用于涂覆辐射纳米颗粒和/或化疗药物的辐射敏感性共聚物载体的制备方法包括通过二硒化物嵌段共聚物和DSPE-PEG-生物标志物形成纳米球，以涂覆可以从开放的纳米球释放的化学药物和/或辐射纳米颗粒， 在质子治疗期间质子穿透组织。 质子治疗的治疗效果通过使用从开放的纳米球释放的辐射纳米颗粒产生核裂变以释放电子以释放肿瘤的肿瘤细胞的质子和从打开的纳米球释放的化疗药物在组织间分布的两种方式得到增强 杀死肿瘤的癌细胞。