公开(公告)号：US11925643B2

公开(公告)日：2024-03-12

申请号：US17057845

申请日：2019-05-23

申请人： MOR RESEARCH APPLICATIONS LTD. ,  BAR ILAN UNIVERSITY

发明人： Edith Hochhauser ,  Arie-Lev Gruzman ,  Elena Trifonov

IPC分类号： A61K31/513 ,  A61K38/06 ,  A61K38/07 ,  A61P9/10 ,  C07D239/47 ,  C07K5/083 ,  C07K5/087 ,  C07K5/103 ,  C07K5/107 ,  C07K5/113

CPC分类号： A61K31/513 ,  A61K38/06 ,  A61K38/07 ,  A61P9/10 ,  C07D239/47 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/1008 ,  C07K5/101 ,  C07K5/1016 ,  C07K5/1021

摘要： Peptides, peptidomimetics and small molecules, collectively referred to as “decoy peptides”, are provided, which interfere with binding to a TIR domain of a toll-like receptor 4 (TLR4), and inhibit a TLR4-induced signaling pathway. These decoy peptides may be useful for treating diseases associated with induction of TLR4 signaling pathway such as a disease or disorder secondary to a cardiovascular disease, sepsis or an inflammatory disease.