公开(公告)号：US20210196717A1

公开(公告)日：2021-07-01

申请号：US17057845

申请日：2019-05-23

Applicant: MOR RESEARCH APPLICATIONS LTD. ,  BAR ILAN UNIVERSITY

Inventor： Edith HOCHHAUSER ,  Arie-Lev GRUZMAN ,  Elena TRIFONOV

IPC: A61K31/513 ,  C07D239/47 ,  A61P9/10 ,  C07K5/103 ,  C07K5/113 ,  C07K5/107 ,  C07K5/087 ,  C07K5/083 ,  A61K38/07 ,  A61K38/06

Abstract: Peptides, peptidomimetics and small molecules, collectively referred to as “decoy peptides”, are provided, which interfere with binding to a TIR domain of a toll-like receptor 4 (TLR4), and inhibit a TLR4-induced signaling pathway. These decoy peptides may be useful for treating diseases associated with induction of TLR4 signaling pathway such as a disease or disorder secondary to a cardiovascular disease, sepsis or an inflammatory disease.