公开(公告)号：US11511028B2

公开(公告)日：2022-11-29

申请号：US16404726

申请日：2019-05-06

Applicant: MUSC Foundation for Research Development

Inventor： Dieter Haemmerich ,  Anjan Motamarry

IPC: A61M1/34 ,  A61K41/00 ,  A61M1/36 ,  A61K49/00

Abstract: A system for reducing toxicity from intravascular triggered drug delivery includes a chamber comprising an inflow port, an outflow port, and a filter positioned upstream of the outflow port. A trigger module is configured to trigger the release of a drug from an intravascular triggered drug delivery system present in blood in the chamber. A method for reducing toxicity from intravascular triggered drug delivery includes the steps of removing blood comprising an intravascular triggered drug delivery system from a patient's vascular system and delivering the blood to a chamber, applying a trigger to the blood to release a drug from the intravascular triggered drug delivery system, filtering the drug from the blood, and returning the filtered blood to the patient.