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    Collagen binding protein compositions and methods of use
    1.
    发明授权
    Collagen binding protein compositions and methods of use 失效
    胶原蛋白结合蛋白组合物和使用方法

    公开(公告)号：US06288214B1

    公开(公告)日：2001-09-11

    申请号：US08856253

    申请日：1997-05-14

    申请人： Magnus Höök ,  Joseph M. Patti ,  Karen House-Pompeo ,  Narayana Sthanam ,  Jindrich Symersky

    发明人： Magnus Höök ,  Joseph M. Patti ,  Karen House-Pompeo ,  Narayana Sthanam ,  Jindrich Symersky

    IPC分类号： C07K1600

    CPC分类号： C07K14/31 ,  A61K38/00 ,  A61K39/00 ,  C07K16/1271 ,  C07K2317/77

    摘要： Disclosed are the cna gene and cna-derived nucleic acid segments from Staphylococcus aureus, and DNA segments encoding cna from related bacteria. Also disclosed are Col binding protein (CBP) compositions and methods of use. The CBP protein and antigenic epitopes derived therefrom are contemplated for use in the treatment of pathological infections, and in particular, for use in the prevention of bacterial adhesion to Col. DNA segments encoding these proteins and anti-(Col binding protein) antibodies will also be of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of bacterial colonization in an animal such as a human. These DNA segments and the peptides derived therefrom are contemplated for use in the preparation of vaccines and, also, for use as carrier proteins in vaccine formulations, and in the formulation of compositions for use in the prevention of S. aureus infection.

    摘要翻译： 公开了来自金黄色葡萄球菌的cna基因和cna衍生的核酸片段以及编码来自相关细菌的cna的DNA片段。 还公开了Col结合蛋白（CBP）组合物和使用方法。 CBP蛋白和源自其的抗原表位被考虑用于治疗病理感染，特别是用于预防细菌粘附到Col。编码这些蛋白质的DNA片段和抗（Col结合蛋白）抗体也将 可用于各种筛选，诊断和治疗应用，包括主动和被动免疫以及用于预防动物如人的细菌定植的方法。 这些DNA片段及其衍生的肽被考虑用于疫苗的制备，也用作疫苗制剂中的载体蛋白，以及用于预防金黄色葡萄球菌感染的组合物的配方。

    Fibronectin binding protein compositions and methods of use
    3.
    发明申请
    Fibronectin binding protein compositions and methods of use 有权
    纤连蛋白结合蛋白组合物和使用方法

    公开(公告)号：US20070110748A1

    公开(公告)日：2007-05-17

    申请号：US11589760

    申请日：2006-10-31

    申请人： Magnus Hook ,  Joseph Patti ,  Karen House-Pompeo ,  Pietro Speziale ,  Danny Joh ,  Martin McGavin

    发明人： Magnus Hook ,  Joseph Patti ,  Karen House-Pompeo ,  Pietro Speziale ,  Danny Joh ,  Martin McGavin

    IPC分类号： A61K39/395 ,  C07K16/18

    CPC分类号： A61K39/085 ,  A61K38/00 ,  A61K39/00 ,  A61K39/092 ,  A61K2039/505 ,  C07K14/31 ,  C07K14/315 ,  C07K16/1271 ,  C07K16/1275 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/76 ,  C07K2319/00 ,  G01N33/6887 ,  G01N2333/31 ,  G01N2333/315 ,  G01N2333/78

    摘要： Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB genes of Staphylococcus aureus, the fnbA and fnbB genes of Streptococcus dysgalactiae, and the sfb gene of Streptococcus pyogenes, and nucleic acid segments encoding these peptides and epitopes. The anti-(fibronectin binding site) antibodies, peptides and epitopes that give rise to antibodies that block the binding of fibronectin binding proteins to fibronectin, and DNA segments encoding these proteins and are of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of streptococcal and staphylococcal colonization in animals or humans. These. DNA segments and the peptides derived therefrom are proposed to be of use directly in the preparation of vaccines and also for use as carrier proteins in vaccine formulations.

    摘要翻译： 公开了阻断纤连蛋白与纤连蛋白结合的抗体。 还公开了衍生自金黄色葡萄球菌的fnbA和fnbB基因的位点特异性突变和截短的肽表位，失语链球菌的fnbA和fnbB基因，以及化脓性链球菌的sfb基因，以及编码这些肽和表位的核酸片段。 产生阻断纤连蛋白结合蛋白与纤连蛋白结合的抗体的抗（纤连蛋白结合位点）抗体，肽和表位，以及编码这些蛋白质的DNA片段，并且可用于各种筛选，诊断和治疗应用，包括活性和 被动免疫和预防动物或人类中链球菌和葡萄球菌定居的方法。 这些。 提出DNA段及其衍生的肽直接用于疫苗的制备，也可用作疫苗制剂中的载体蛋白。