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    Fibronectin binding protein compositions and methods of use
    2.
    发明授权
    Fibronectin binding protein compositions and methods of use 有权
    纤连蛋白结合蛋白组合物和使用方法

    公开(公告)号：US07128912B2

    公开(公告)日：2006-10-31

    申请号：US10731238

    申请日：2003-12-10

    申请人： Magnus Höök ,  Joseph M. Patti ,  Karen L. House-Pompeo ,  Pietro Speziale ,  Danny Joh ,  Martin J. McGavin

    发明人： Magnus Höök ,  Joseph M. Patti ,  Karen L. House-Pompeo ,  Pietro Speziale ,  Danny Joh ,  Martin J. McGavin

    IPC分类号： A61K39/00

    CPC分类号： A61K39/085 ,  A61K38/00 ,  A61K39/00 ,  A61K39/092 ,  A61K2039/505 ,  C07K14/31 ,  C07K14/315 ,  C07K16/1271 ,  C07K16/1275 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/76 ,  C07K2319/00 ,  G01N33/6887 ,  G01N2333/31 ,  G01N2333/315 ,  G01N2333/78

    摘要： Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB genes of Staphylococcus aureus, the fnbA and fnbB genes of Streptococcus dysgalactiae, and the sfb gene of Streptococcus pyogenes, and nucleic acid segments encoding these peptides and epitopes. The anti-(fibronectin binding site) antibodies, peptides and epitopes that give rise to antibodies that block the binding of fibronectin binding proteins to fibronectin, and DNA segments encoding these proteins and are of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of streptococcal and staphylococcal colonization in animals or humans. These DNA segments and the peptides derived therefrom are proposed to be of use directly in the preparation of vaccines and also for use as carrier proteins in vaccine formulations.

    摘要翻译： 公开了阻断纤连蛋白与纤连蛋白结合的抗体。 还公开了衍生自金黄色葡萄球菌的fnbA和fnbB基因的位点特异性突变和截短的肽表位，失语链球菌的fnbA和fnbB基因，以及化脓性链球菌的sfb基因，以及编码这些肽和表位的核酸片段。 产生阻断纤连蛋白结合蛋白与纤连蛋白结合的抗体的抗（纤连蛋白结合位点）抗体，肽和表位，以及编码这些蛋白质的DNA片段，并且可用于各种筛选，诊断和治疗应用，包括活性和 被动免疫和预防动物或人类中链球菌和葡萄球菌定居的方法。 提出这些DNA片段及其衍生的肽直接用于疫苗的制备，也可用作疫苗制剂中的载体蛋白。

    CROSS-REACTIVE DISPLACING ANTIBODIES FROM COLLAGEN-BINDING PROTEINS AND METHOD OF IDENTIFICATION AND USE
    4.
    发明申请
    CROSS-REACTIVE DISPLACING ANTIBODIES FROM COLLAGEN-BINDING PROTEINS AND METHOD OF IDENTIFICATION AND USE 有权
    来自胶原蛋白结合蛋白的交叉反应位移抗体及其鉴定和使用方法

    公开(公告)号：US20070122416A1

    公开(公告)日：2007-05-31

    申请号：US09810428

    申请日：2001-03-19

    申请人： Magnus Hook ,  Yi Xu ,  Pietro Speziale ,  Livia Visal ,  Fabrizia Casolini ,  Joseph Patti ,  Pratiksha Patel ,  Paul Domanski

    发明人： Magnus Hook ,  Yi Xu ,  Pietro Speziale ,  Livia Visal ,  Fabrizia Casolini ,  Joseph Patti ,  Pratiksha Patel ,  Paul Domanski

    IPC分类号： A61K39/40 ,  G01N33/554 ,  C07K16/12

    CPC分类号： C07K16/1271 ,  A61K39/085 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  G01N33/56938 ,  G01N2333/31 ,  G01N2333/78 ,  G01N2500/00

    摘要： Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus aureus and Staphylococcus epidermidis bacteria and which can thus be used in the prevention and treatment of infections caused by both of these types of bacteria. In addition, medical instruments can be treated using the antibodies of the invention in order to reduce or eliminate the possibility of their becoming infected or further spreading the infection. In particular, the proteins are advantageous because they are cross-reactive and may thus be administered to patients so as to reduce or prevent severe infection by staphylococcal bacteria of more than one species. Antibodies generated in this manner have also been shown to exhibit displacement activity and can thus be utilized advantageously in methods wherein these antibodies will be administered to patients having pre-existing staphylococcal infections because of the ability to displace bacterial proteins from binding sites on the extracellular matrix. Finally, a method of identifying, isolating and utilizing displacing antibodies is also provided.

    摘要翻译： 提供了对CNA蛋白和来自胶原结合结构域的其他区域（包括结构域CNA19）的抗体，并且以这种方式产生的抗体已显示与金黄色葡萄球菌和表皮葡萄球菌交叉反应，因此可以用于 预防和治疗由这两种细菌引起的感染。 此外，可以使用本发明的抗体治疗医疗器械，以便减少或消除它们被感染或进一步扩散感染的可能性。 特别地，蛋白质是有利的，因为它们是交叉反应性的，并且因此可以施用于患者，以便减少或预防多于一种物种的葡萄球菌细菌的严重感染。 以这种方式产生的抗体也已显示出显示置换活性，因此可有利地用于其中将这些抗体施用于具有预先存在的葡萄球菌感染的患者的方法，因为能够从细胞外基质上的结合位点置换细菌蛋白质 。 最后，还提供了鉴定，分离和利用置换抗体的方法。

    SURFACE PROTEINS FROM COAGULASE-NEGATIVE STAPHYLOCOCCI AND STAPHYLOCOCCUS AUREUS THAT GENERATE CROSS-REACTIVE MONOCLONAL AND POLYCLONAL ANTIBODIES
    7.
    发明申请
    SURFACE PROTEINS FROM COAGULASE-NEGATIVE STAPHYLOCOCCI AND STAPHYLOCOCCUS AUREUS THAT GENERATE CROSS-REACTIVE MONOCLONAL AND POLYCLONAL ANTIBODIES 有权
    生成交联反应性单环和多环抗体的凝聚酶阴性和石蜡切片的表面蛋白

    公开(公告)号：US20090202578A1

    公开(公告)日：2009-08-13

    申请号：US12365481

    申请日：2009-02-04

    申请人： Timothy FOSTER ,  Fiona Roche ,  Mark Pallen ,  Joseph M. Patti ,  Jeff T. Hutchins ,  Pietro Speziale

    发明人： Timothy FOSTER ,  Fiona Roche ,  Mark Pallen ,  Joseph M. Patti ,  Jeff T. Hutchins ,  Pietro Speziale

    IPC分类号： A61K39/085 ,  A61K38/16 ,  G01N33/569

    CPC分类号： C07K16/1271

    摘要： Surface proteins are provided which generate polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. aureus and to coagulase-negative bacteria, such as S. epidermidis and S. hemolyticus. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, or the A domains of those surface proteins, and these recombinant surface proteins are used to generate the cross-reactive antibodies. Vaccines comprising an immunologically effective amount of the proteins are also provided, and these vaccines are used in methods for the treatment or protection against a wide variety of staphylococcal infections.

    摘要翻译： 提供了表达蛋白，其产生与凝固酶阳性葡萄球菌如金黄色葡萄球菌和凝血酶阴性细菌如表皮葡萄球菌和溶血性葡萄球菌的交叉反应性的多克隆和单克隆抗体。 抗体可以从基于在金黄色葡萄球菌和凝固酶阴性葡萄球菌或这些表面蛋白质的A结构域可能是常见的特征分离的表面蛋白产生，并且这些重组表面蛋白质用于产生 交叉反应性抗体。 还提供了包含免疫有效量的蛋白质的疫苗，并且这些疫苗用于治疗或保护免受各种葡萄球菌感染的方法中。

    Fibronectin binding protein compositions and methods of use
    8.
    发明授权
    Fibronectin binding protein compositions and methods of use 失效
    纤连蛋白结合蛋白组合物和使用方法

    公开(公告)号：US06685943B1

    公开(公告)日：2004-02-03

    申请号：US09010317

    申请日：1998-01-21

    申请人： Magnus Höök ,  Joseph M. Patti ,  Karen L. House-Pompeo ,  Pietro Speziale ,  Danny Joh ,  Martin J. McGavin

    发明人： Magnus Höök ,  Joseph M. Patti ,  Karen L. House-Pompeo ,  Pietro Speziale ,  Danny Joh ,  Martin J. McGavin

    IPC分类号： A61K3900

    CPC分类号： A61K39/085 ,  A61K38/00 ,  A61K39/00 ,  A61K39/092 ,  A61K2039/505 ,  C07K14/31 ,  C07K14/315 ,  C07K16/1271 ,  C07K16/1275 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/76 ,  C07K2319/00 ,  G01N33/6887 ,  G01N2333/31 ,  G01N2333/315 ,  G01N2333/78

    摘要： Disclosed are antibodies that block the binding of fibronectin protein to fibronectin. Also disclosed are site specifically-mutated and truncated peptide epitopes derived from the fnbA and fnbB genes of Staphylococcus aureus, the fnba and fnbB genes of Streptococcus dysgalactiae, and the sfb gene of Streptococcus pyogenes, and nucleic acid segments encoding these peptides and epitopes. The anti-(fibronectin binding site) antibodies, peptides and epitopes that give rise to antibodies that block the binding of fibronectin binding proteins to fibronectin, and DNA segments encoding these proteins and are of use in various screening, diagnostic and therapeutic applications including active and passive immunization and methods for the prevention of streptococcal and staphylococcal colonization in animals or humans. These. DNA segments and the peptides derived therefrom are proposed to be of use directly in the preparation of vaccines and also for use as carrier proteins in vaccine formulations.

    摘要翻译： 公开了阻断纤连蛋白与纤连蛋白结合的抗体。 还公开了衍生自金黄色葡萄球菌的fnbA和fnbB基因的位点特异性突变和截短的肽表位，来自失血性链球菌的fnba和fnbB基因，以及化脓性链球菌的sfb基因，以及编码这些肽和表位的核酸片段。 产生阻断纤连蛋白结合蛋白与纤连蛋白结合的抗体的抗（纤连蛋白结合位点）抗体，肽和表位，以及编码这些蛋白质的DNA片段，并且可用于各种筛选，诊断和治疗应用，包括活性和 被动免疫和预防动物或人类中链球菌和葡萄球菌定居的方法。 这些。 提出DNA段及其衍生的肽直接用于疫苗的制备，也可用作疫苗制剂中的载体蛋白。

    Surface proteins from coagulase-negative staphylococci and Staphylococcus aureus that generate cross-reactive monoclonal and polyclonal antibodies
    9.
    发明授权
    Surface proteins from coagulase-negative staphylococci and Staphylococcus aureus that generate cross-reactive monoclonal and polyclonal antibodies 有权
    产生交叉反应性单克隆和多克隆抗体的来自凝固酶阴性葡萄球菌和金黄色葡萄球菌的表面蛋白

    公开(公告)号：US07968100B2

    公开(公告)日：2011-06-28

    申请号：US12365481

    申请日：2009-02-04

    申请人： Timothy Foster ,  Fiona Roche ,  Mark Pallen ,  Joseph M. Patti ,  Jeff T. Hutchins ,  Pietro Speziale

    发明人： Timothy Foster ,  Fiona Roche ,  Mark Pallen ,  Joseph M. Patti ,  Jeff T. Hutchins ,  Pietro Speziale

    IPC分类号： A61K39/085 ,  A61K38/16 ,  G01N33/569

    CPC分类号： C07K16/1271

    摘要： Surface proteins are provided which generate polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positive staphylococcus bacteria, such as S. aureus and to coagulase-negative bacteria, such as S. epidermidis and S. hemolyticus. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common between S. aureus and coagulase-negative staphylococci, or the A domains of those surface proteins, and these recombinant surface proteins are used to generate the cross-reactive antibodies. Vaccines comprising an immunologically effective amount of the proteins are also provided, and these vaccines are used in methods for the treatment or protection against a wide variety of staphylococcal infections.

    摘要翻译： 提供了表达蛋白，其产生与凝固酶阳性葡萄球菌如金黄色葡萄球菌和凝血酶阴性细菌如表皮葡萄球菌和溶血性葡萄球菌的交叉反应性的多克隆和单克隆抗体。 抗体可以从基于在金黄色葡萄球菌和凝固酶阴性葡萄球菌或这些表面蛋白质的A结构域可能是常见的特征分离的表面蛋白产生，并且这些重组表面蛋白质用于产生 交叉反应性抗体。 还提供了包含免疫有效量的蛋白质的疫苗，并且这些疫苗用于治疗或保护免受各种葡萄球菌感染的方法中。

    Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use
    10.
    发明授权
    Cross-reactive displacing antibodies from collagen-binding proteins and method of identification and use 有权
    来自胶原蛋白结合蛋白的交叉反应置换抗体及鉴定和使用方法

    公开(公告)号：US07241592B2

    公开(公告)日：2007-07-10

    申请号：US09810428

    申请日：2001-03-19

    申请人： Magnus Hook ,  Yi Xu ,  Pietro Speziale ,  Livia Visal ,  Fabrizia Casolini ,  Joseph M. Patti ,  Pratiksha Patel ,  Paul Domanski

    发明人： Magnus Hook ,  Yi Xu ,  Pietro Speziale ,  Livia Visal ,  Fabrizia Casolini ,  Joseph M. Patti ,  Pratiksha Patel ,  Paul Domanski

    IPC分类号： C12P21/08 ,  C12N1/00 ,  A61K39/395 ,  A61K39/40 ,  C07K16/12

    CPC分类号： C07K16/1271 ,  A61K39/085 ,  A61K2039/505 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  G01N33/56938 ,  G01N2333/31 ,  G01N2333/78 ,  G01N2500/00

    摘要： Antibodies to the CNA protein and to other regions from the collagen binding domain, including domain CNA19, are provided, and antibodies produced in this manner have been shown to be cross reactive to both Staphylococcus aureus and Staphylococcus epidermidis bacteria and which can thus be used in the prevention and treatment of infections caused by both of these types of bacteria. In addition, medical instruments can be treated using the antibodies of the invention in order to reduce or eliminate the possibility of their becoming infected or further spreading the infection. In particular, the proteins are advantageous because they are cross-reactive and may thus be administered to patients so as to reduce or prevent severe infection by staphylococcal bacteria of more than one species. Antibodies generated in this manner have also been shown to exhibit displacement activity and can thus be utilized advantageously in methods wherein these antibodies will be administered to patients having pre-existing staphylococcal infections because of the ability to displace bacterial proteins from binding sites on the extracellular matrix. Finally, a method of identifying, isolating and utilizing displacing antibodies is also provided.

    摘要翻译： 提供了对CNA蛋白和来自胶原结合结构域的其他区域（包括结构域CNA19）的抗体，并且以这种方式产生的抗体已显示与金黄色葡萄球菌和表皮葡萄球菌交叉反应，因此可以用于 预防和治疗由这两种细菌引起的感染。 此外，可以使用本发明的抗体治疗医疗器械，以便减少或消除它们被感染或进一步扩散感染的可能性。 特别地，蛋白质是有利的，因为它们是交叉反应性的，并且因此可以施用于患者，以便减少或预防多于一种物种的葡萄球菌细菌的严重感染。 以这种方式产生的抗体也已显示出显示置换活性，因此可有利地用于其中将这些抗体施用于具有预先存在的葡萄球菌感染的患者的方法，因为能够从细胞外基质上的结合位点置换细菌蛋白质 。 最后，还提供了鉴定，分离和利用置换抗体的方法。