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    Identification of cancer biomarkers and phosphorylated pdroteins
    2.
    发明申请
    Identification of cancer biomarkers and phosphorylated pdroteins 审中-公开
    鉴定癌症生物标志物和磷酸化pdroteins

    公开(公告)号：US20070105181A1

    公开(公告)日：2007-05-10

    申请号：US11417264

    申请日：2006-05-04

    申请人： Robert Pope ,  Xiquan Liang ,  Mahbod Hajivandi ,  John Leite

    发明人： Robert Pope ,  Xiquan Liang ,  Mahbod Hajivandi ,  John Leite

    IPC分类号： C12Q1/37

    CPC分类号： G01N33/57415 ,  G01N33/57496 ,  G01N33/60 ,  Y10T436/143333

    摘要： Methods are provided for identifying proteins that are differentially expressed in disease state and normal cells. Stable isotope labeling of cells in culture allows for the identification of a multiplicity of proteins whose differential abundance in normal and disease state cells can be indicative of the disease state. Biomarkers are identified for breast cancer, in which the biomarkers are proteins having a two-fold or greater difference in abundance between breast cancer and normal cells. Identified biomarkers can be used detection methods that can provide diagnosis, typing, staging, or prognosis of cancer, such as breast cancer, or can be used to predict the response of cancer, such as breast cancer, to one or more anti-cancer agents.

    摘要翻译： 提供了用于鉴定在疾病状态和正常细胞中差异表达的蛋白质的方法。 培养物中细胞的稳定同位素标记允许鉴定多种蛋白质，其正常和疾病状态细胞中的差异丰度可以指示疾病状态。 鉴定乳腺癌的生物标志物，其中生物标志物是乳腺癌和正常细胞之间丰度差异大于2倍或更大的蛋白质。 可以使用识别的生物标志物可以提供诸如乳腺癌的癌症的诊断，分型，分期或预后的检测方法，或者可以用于预测癌症如乳腺癌对一种或多种抗癌剂的反应 。

    Isotopically-labeled proteome standards
    3.
    发明申请
    Isotopically-labeled proteome standards 有权
    同位素标记的蛋白质组标准

    公开(公告)号：US20070031911A1

    公开(公告)日：2007-02-08

    申请号：US11368996

    申请日：2006-03-07

    申请人： John Leite ,  Robert Pope ,  Mahbod Hajivandi ,  Xiquan Liang

    发明人： John Leite ,  Robert Pope ,  Mahbod Hajivandi ,  Xiquan Liang

    IPC分类号： C12Q1/37 ,  G01N33/50

    CPC分类号： G01N27/62 ,  G01N33/60 ,  G01N33/6848 ,  G01N33/6851 ,  G01N2458/15 ,  Y10T436/24

    摘要： The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest. Methods of the present invention also include methods for quantifying biomolecules where the copy biomolecule standard is made by expressing the biomolecule using a recombinant cell. Further included are the biomolecule standards themselves, method for making such standards, kits, systems, reagents, and engineered cells relating to the use of biomolecule standards in mass spectrometric analysis.

    摘要翻译： 本发明提供了在质谱分析中定量生物分子例如多肽的方法。 该方法包括使用具有与感兴趣的生物分子中天然存在的同位素不同的至少一个原子同位素的生物分子标准。 本发明的方法还包括用于定量生物分子的方法，其中通过使用重组细胞表达生物分子来制备复制生物分子标准物。 还包括生物分子标准本身，制备此类标准的方法，试剂盒，系统，试剂和与质谱分析中使用生物分子标准有关的工程细胞。

    Oil pan bolt with retaining means
    6.
    发明授权
    Oil pan bolt with retaining means 失效
    油盘螺栓带固定装置

    公开(公告)号：US5628601A

    公开(公告)日：1997-05-13

    申请号：US583885

    申请日：1996-01-11

    申请人： Robert Pope

    发明人： Robert Pope

    IPC分类号： F01M11/04 ,  F16B35/02 ,  F16L55/10

    CPC分类号： F01M11/0408 ,  Y10S411/999

    摘要： An oil pan bolt with a standard bolt head and a sealing flange that fits against the oil pan. Extending from the head of the bolt is a threaded portion that is inserted into the threads of the oil pan drain hole. An extension piece extends from the distal end of the threaded portion of the bolt. At a distal end of the extension piece is a retaining element. One way of forming the retaining element is to have another small threaded portion at the distal end of the extension piece.

    摘要翻译： 一个带有标准螺栓头和密封凸缘的油盘螺栓，适合油盘。 从螺栓的头部延伸的是螺纹部分，其插入油盘排放孔的螺纹中。 延伸件从螺栓的螺纹部分的远端延伸。 在延伸件的远端处是保持元件。 形成保持元件的一种方式是在延伸件的远端具有另一小的螺纹部分。