-
公开(公告)号：US5068110A
公开(公告)日：1991-11-26
申请号：US379727
申请日：1989-07-14
IPC分类号： A61K9/48
CPC分类号： A61K9/4891
摘要： The present invention is a stabilized enteric-coated pharmaceutical dosage form and processes for the preparation thereof. Dissolution stability after storage of the dosage form under high stress conditions is improved by an enteric-coated dosage form having an enteric coating wherein the coating is of the acrylic resin kind of from 14 mg/cm.sup.2 to 24 mg/cm.sup.2 or an enteric coating wherein the coating is of the acetate kind of from 14 mg/cm.sup.2 to 24 mg/cm.sup.2 and having a second coating of hydrophilic coating for example, hydroxypropyl cellulose, hydroxymethyl cellulose or hydroxypropylmethyl cellulose.
摘要翻译： 本发明是一种稳定的肠溶包衣药物剂型及其制备方法。 通过具有肠溶衣的肠溶衣剂形式，其中所述涂层为14mg / cm 2至24mg / cm 2的丙烯酸树脂类型或肠溶衣，其中在高应激条件下储存剂型之后的溶解稳定性得到改善，其中 该涂层的醋酸盐类型为14mg / cm 2至24mg / cm 2，并且具有亲水涂层的第二涂层，例如羟丙基纤维素，羟甲基纤维素或羟丙基甲基纤维素。
-
公开(公告)号：US4931519A
公开(公告)日：1990-06-05
申请号：US347630
申请日：1989-05-05
CPC分类号： C08F26/06 , A61K9/284 , A61K9/2846 , A61K9/7023 , A61L15/24 , C07D207/38 , G02B1/043
摘要： A new series of copolymers which are useful as coatings for solid dosage forms, for transdermal devices, for wound dressing materials, and for contact lenses. Also disclosed are methods for preparing monomers and polymers as well as pharmaceutical compositions containing such polymers.
摘要翻译： 可用作固体剂型涂层，透皮装置，伤口敷料材料和隐形眼镜的新系列共聚物。 还公开了制备单体和聚合物的方法以及含有这种聚合物的药物组合物。
-
公开(公告)号：US4830853A
公开(公告)日：1989-05-16
申请号：US921717
申请日：1986-10-20
申请人： Kuchi S. Murthy , Michael R. Harris , Gerard C. Hokanson , Robert G. Reisch, Jr. , Mahdi B. Fawzi , Frank Waldman
发明人： Kuchi S. Murthy , Michael R. Harris , Gerard C. Hokanson , Robert G. Reisch, Jr. , Mahdi B. Fawzi , Frank Waldman
IPC分类号： A61K45/08 , A61K31/40 , A61K31/401 , A61K31/44 , A61K31/47 , A61K47/00 , A61K47/12 , A61K47/22 , A61P9/12 , A61P43/00
摘要： The oxidation--and color-stability of certain ace inhibitors is optimized when they are formulated with a stabilizer and at least one lubricant and/or excipient.
-
公开(公告)号：US4851545A
公开(公告)日：1989-07-25
申请号：US57467
申请日：1987-06-02
CPC分类号： C08F26/06 , A61K9/284 , A61K9/2846 , A61K9/7023 , A61L15/24 , C07D207/38 , G02B1/043
摘要： A new series of copolymers such as N-isopropyl-3-methylene-2-pyrrolidone and 2-hydroxyethylmethacrylate which are useful as coatings for solid dosage forms, for transdermal devices, for wound dressing materials, and for contact lenses. Also disclosed are methods for preparing monomers and polymers as well as pharmaceutical compositions containing such polymers.
摘要翻译： 新的一系列共聚物，如N-异丙基-3-亚甲基-2-吡咯烷酮和甲基丙烯酸2-羟基乙酯，可用作固体剂型的涂层，用于透皮装置，伤口敷料材料和隐形眼镜。 还公开了制备单体和聚合物的方法以及含有这种聚合物的药物组合物。
-
5.发明授权Methylene pyrrolidone copolymers for contact lens and pharmaceutical preparations 失效用于隐形眼镜和药物制剂的亚甲基吡咯烷酮共聚物
公开(公告)号：US5035884A
公开(公告)日：1991-07-30
申请号：US480431
申请日：1990-02-15
CPC分类号： A61K9/7053 , A61K9/284 , A61K9/2846 , A61K9/7061 , A61L15/24 , C07D207/38 , C08F26/06 , G02B1/043
摘要： A new series of copolymers which are useful as coatings for solid dosage forms, for transdermal devices, for wound dressing materials, and for contact lenses. Also disclosed are methods for preparing monomers and polymers as well as pharmaceutical compositions containing such polymers.
摘要翻译： 可用作固体剂型涂层，透皮装置，伤口敷料材料和隐形眼镜的新系列共聚物。 还公开了制备单体和聚合物的方法以及含有这种聚合物的药物组合物。
-
公开(公告)号：US4793998A
公开(公告)日：1988-12-27
申请号：US921931
申请日：1986-10-20
申请人： Kuchi S. Murthy , Michael R. Harris , Gerard C. Hokanson , Robert G. Reisch, Jr. , Frank Waldman , Mahdi B. Fawzi
发明人： Kuchi S. Murthy , Michael R. Harris , Gerard C. Hokanson , Robert G. Reisch, Jr. , Frank Waldman , Mahdi B. Fawzi
IPC分类号： A61K45/08 , A61K31/40 , A61K31/401 , A61K31/44 , A61K31/47 , A61K47/00 , A61K47/12 , A61K47/22 , A61P9/12 , A61P43/00 , A61K9/68 , A61K31/195 , A61K31/27
CPC分类号： A61K47/22 , A61K31/40 , A61K31/44 , A61K47/12 , Y10S514/97
摘要： The cyclization and hydrolysis of certain ACE inhibitors is minimized when they are formulated with a stabilizer and at least one lubricant and/or excipient.
-
公开(公告)号：US20090137559A1
公开(公告)日：2009-05-28
申请号：US12363906
申请日：2009-02-02
申请人： Mahdi B. Fawzi , Kadum A. Ali , Syed M. Shah
发明人： Mahdi B. Fawzi , Kadum A. Ali , Syed M. Shah
IPC分类号： A61K31/55 , C07D403/12 , A61P35/00
CPC分类号： C07D209/12
摘要： The present invention is directed to bazedoxifene ascorbate, compositions containing the same, dispersions thereof, preparations thereof, and uses thereof.
摘要翻译： 本发明涉及抗坏血酸巴西多昔芬，含有它们的组合物，其分散体，制剂及其用途。
-
公开(公告)号：US06677357B2
公开(公告)日：2004-01-13
申请号：US10224971
申请日：2002-08-22
申请人： Tianmin Zhu , Mahdi B. Fawzi
发明人： Tianmin Zhu , Mahdi B. Fawzi
IPC分类号： A61K31445
CPC分类号： C07D405/06 , C07D493/08
摘要： This invention provides non-immunosuppressive rapamycin 29-enols, which are useful as neurotrophic agents, in the treatment of solid tumors, and vascular disease.
摘要翻译： 本发明提供了用于治疗实体瘤和血管疾病的非免疫抑制雷帕霉素29-烯醇，其可用作神经营养剂。
-
公开(公告)号：US4925676A
公开(公告)日：1990-05-15
申请号：US305083
申请日：1989-02-02
申请人： Isaac Ghebre-Sellassie , Uma Iyer , Mahdi B. Fawzi
发明人： Isaac Ghebre-Sellassie , Uma Iyer , Mahdi B. Fawzi
CPC分类号： A61K31/19 , A61K9/2081
摘要： A disintegratable gemfibrozil tablet providing both immediate and enteric release is compressed from a mixture of a first granulation of gemfibrozil with at least one acid-disintegratable binder and a second granulation formed from the first granulation but regranulated or coated with an alkali-disintegratable formulation of at least one substantially alkali-soluble and substantially acid-insoluble polymer.
-
公开(公告)号：USD302481S
公开(公告)日：1989-07-25
申请号：US111525
申请日：1987-10-21
-
-
-
-
-
-
-
-
-
搜索结果
62 条记录 (耗时 0.022 秒)
