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272 条记录 (耗时 0.043 秒)

    Diaryl ketimine derivative
    2.
    发明申请
    Diaryl ketimine derivative 审中-公开
    二芳基酮亚胺衍生物

    公开(公告)号：US20090247560A1

    公开(公告)日：2009-10-01

    申请号：US12310951

    申请日：2007-09-27

    申请人： Makoto Ando ,  Minoru Kameda ,  Hiroshi Miyazoe ,  Minoru Moriya ,  Etsuko Sekino ,  Takao Suzuki

    发明人： Makoto Ando ,  Minoru Kameda ,  Hiroshi Miyazoe ,  Minoru Moriya ,  Etsuko Sekino ,  Takao Suzuki

    IPC分类号： A61K31/438 ,  C07D401/14 ,  A61P3/04 ,  A61P3/10 ,  A61P25/22 ,  A61P25/24

    CPC分类号： C07D491/20

    摘要： Provided is a compound of a formula (I): [wherein R1a and R1b are the same or different, representing a hydrogen atom, etc.; R2a and R2b are the same or different, representing a hydrogen atom, etc., or R2a and R2b, taken together, form —CH2CH2—, R3a and R3b are the same or different, representing a hydrogen atom, etc.; or R3a and R3b, taken together, form —CH2CH2-etc.; Y1 and Y2 represent —C(R)2—, etc.; Z represents OR, NR2, etc.; R represents a hydrogen atom, a C1-6 alkyl group, etc.; Ar1 represents a 6-membered aromatic carbocyclic group, etc.; Ar2 represents a 6-membered aromatic carbocyclic group, etc; A3 represents a 6-membered aromatic carbocyclic group etc.]. The compound is useful as a medicine for central disorders, cardiovascular disorders, metabolic disorders.

    摘要翻译： 提供式（I）的化合物：其中R 1a和R 1b相同或不同，表示氢原子等; R2a和R2b相同或不同，表示氢原子等，或者R 2a和R 2b一起形成-CH 2 CH 2 - ，R 3a和R 3b相同或不同，表示氢原子等; 或R3a和R3b一起形成-CH 2 CH 2等; Y1和Y2表示-C（R）2-等; Z表示OR，NR2等; R表示氢原子，C 1-6烷基等; Ar 1表示6元芳族碳环基等。 Ar2表示6元芳族碳环基团等; A3表示6元芳族碳环基等]。 该化合物可用作中枢性疾病，心血管疾病，代谢紊乱的药物。

    SPIRODIAMINE-DIARYL KETOXIME DERIVATIVE
    3.
    发明申请
    SPIRODIAMINE-DIARYL KETOXIME DERIVATIVE 审中-公开
    螺吡啶二脱氧胆固醇衍生物

    公开(公告)号：US20110071129A1

    公开(公告)日：2011-03-24

    申请号：US12993928

    申请日：2009-06-11

    申请人： Makoto Ando ,  Etsuki Hirose ,  Kouta Masutani ,  Minoru Moriya ,  Takao Suzuki

    发明人： Makoto Ando ,  Etsuki Hirose ,  Kouta Masutani ,  Minoru Moriya ,  Takao Suzuki

    IPC分类号： A61K31/4427 ,  C07D487/10 ,  A61K31/444 ,  A61P3/04 ,  A61P3/10 ,  A61P1/16 ,  A61P25/24 ,  A61P25/22 ,  A61K31/5025 ,  A61K31/497

    CPC分类号： C07D471/20 ,  A61K31/13 ,  C07D487/10 ,  C07D519/00

    摘要： [Problem] To provide a melanin concentrating hormone receptor antagonist useful as medicines for central system disorders, cardiovascular disorders, metabolic disorders.[Means for Resolution] Provided are compound of a formula (I): [wherein R1 a and R1 b each are a hydrogen atom, etc.; R2 is a hydrogen atom, a C1-6 alkyl, etc.; Ar1 is a 6-membered aromatic carbocyclic group or a 6-membered aromatic nitrogen-containing heterocyclic group; Ar2 is a group to be formed by removing two hydrogen atoms from a 6-membered aromatic carbon ring, a 6-membered aromatic nitrogen-containing hetero ring, etc.; Ar3 is a mono- or bi-cyclic aromatic carbon ring or aromatic hetero ring; m1, m2, m3 and m4 each are independently 0, 1, 2, 3 or 4, provided that the total of m1 and m2 is from 2 to 6, the total of m3 and m4 is from 2 to 6]. The compounds are useful as medicines for central system disorders, cardiovascular disorders, metabolic disorders.

    摘要翻译： [问题]提供可用作中枢系统疾病，心血管疾病，代谢紊乱的药物的黑色素浓缩激素受体拮抗剂。 [分解方法]提供式（I）的化合物：[其中R1 a和R1b各自为氢原子等; R2是氢原子，C1-6烷基等; Ar 1是6元芳族碳环基或6元芳族含氮杂环基; Ar 2是通过从6元芳族碳环，6元芳族含氮杂环等除去2个氢原子而形成的基团; Ar 3是单环或双环芳族碳环或芳族杂环; m1，m2，m3和m4各自独立为0,1,2,3或4，条件是m1和m2的总和为2至6，m3和m4的总和为2至6]。 该化合物可用作中枢系统疾病，心血管疾病，代谢紊乱的药物。

    2-aminoquinoline derivatives
    6.
    发明授权
    2-aminoquinoline derivatives 失效
    2-氨基喹啉衍生物

    公开(公告)号：US07485647B2

    公开(公告)日：2009-02-03

    申请号：US10556932

    申请日：2004-05-20

    申请人： Minoru Moriya ,  Takao Suzuki ,  Akane Ishihara ,  Hisashi Iwaasa ,  Akio Kanatani

    发明人： Minoru Moriya ,  Takao Suzuki ,  Akane Ishihara ,  Hisashi Iwaasa ,  Akio Kanatani

    IPC分类号： C07D401/12 ,  C07D401/14 ,  A61K31/506

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D487/04 ,  C07D487/10

    摘要： This invention provides 2-aminoquinoline derivatives represented by a general formula [I] [in which R1 and R2 either stand for lower alkyl, lower cycloalkyl, etc., or R1 and R2 together form an aliphatic nitrogen-containing heterocycle with the nitrogen atom to which they bind; R3, R4, R5, R6 and R7 stand for hydrogen, lower alkyl, etc.; R8 stands for lower alkyl, lower alkyloxy, etc.; and n stands for an integer of 0-4]. The compounds act as melanin concentrating hormone receptor antagonist, and are useful as medicines for central nervous system disorders, cardiovascular disorders and metabolic disorders.

    摘要翻译： 本发明提供由通式[I]表示的2-氨基喹啉衍生物[其中R 1和R 2表示低级烷基，低级环烷基等，或者R 1和R 2一起与氮原子一起形成脂族含氮杂环， 他们绑定 R3，R4，R5，R6和R7代表氢，低级烷基等; R8代表低级烷基，低级烷氧基等; 并且n表示0-4的整数]。 该化合物作为黑色素浓缩激素受体拮抗剂，可用作中枢神经系统疾病，心血管疾病和代谢紊乱的药物。

    Imidazopyridine Derivatives
    7.
    发明申请
    Imidazopyridine Derivatives 失效
    咪唑并吡啶衍生物

    公开(公告)号：US20080200494A1

    公开(公告)日：2008-08-21

    申请号：US10567269

    申请日：2004-08-13

    申请人： Hiroyuki Kishino ,  Minoru Moriya ,  Toshihiro Sakamoto ,  Hidekazu Takahashi ,  Shunji Sakuraba ,  Takao Suzuki ,  Akio Kanatani

    发明人： Hiroyuki Kishino ,  Minoru Moriya ,  Toshihiro Sakamoto ,  Hidekazu Takahashi ,  Shunji Sakuraba ,  Takao Suzuki ,  Akio Kanatani

    IPC分类号： A61K31/437 ,  A61P3/10 ,  C07D471/04

    CPC分类号： C07D471/04

    摘要： The invention provides imidazopyridine derivatives represented by the general formula [I] [in which R1 and R2 may be the same or different and stand for C1-6 alkyl or the like, R3 and R4 stand for hydrogen atom, methyl group or the like, W stands for mono- or bi-cyclic 3- to 8-membered aromatic or aliphatic heterocycle or the like, and Ar stands for optionally substituted aromatic heterocycle or the like]. These compounds act as melanin-concentrating hormone receptor antagonist and are useful as medicines for central nervous system disorders, cardiovascular system disorders and metabolic disorders.

    摘要翻译： 本发明提供由通式[I]表示的咪唑并吡啶衍生物[其中R 1'和R 2'可以相同或不同，代表C 1〜 6个烷基等，R 3和R 4代表氢原子，甲基等，W代表单环或双环3 - 至8-元芳族或脂族杂环等，Ar表示任选取代的芳族杂环等〕。 这些化合物作为黑色素浓缩激素受体拮抗剂起作用，可用作中枢神经系统疾病，心血管系统疾病和代谢紊乱的药物。

    2-Aminoquinoline derivatives
    8.
    发明申请
    2-Aminoquinoline derivatives 失效
    2-氨基喹啉衍生物

    公开(公告)号：US20060287340A1

    公开(公告)日：2006-12-21

    申请号：US10556932

    申请日：2004-05-20

    申请人： Minoru Moriya ,  Takao Suzuki ,  Akane Ishihara ,  Hisashi Iwaasa ,  Akio Kanatani

    发明人： Minoru Moriya ,  Takao Suzuki ,  Akane Ishihara ,  Hisashi Iwaasa ,  Akio Kanatani

    IPC分类号： A61K31/506 ,  C07D403/14

    CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D487/04 ,  C07D487/10

    摘要： This invention provides 2-aminoquinoline derivatives represented by a general formula [I] [in which R1 and R2 either stand for lower alkyl, lower cycloalkyl, etc., or R1 and R2 together form an aliphatic nitrogen-containing heterocycle with the nitrogen atom to which they bind; R3, R4, R5, R6 and R7 stand for hydrogen, lower alkyl, etc.; R8 stands for lower alkyl, lower alkyloxy, etc.; and n stands for an integer of 0-4]. The compounds act as melanin concentrating hormone receptor antagonist, and are useful as medicines for central nervous system disorders, cardiovascular disorders and metabolic disorders.

    摘要翻译： 本发明提供由通式[I]表示的2-氨基喹啉衍生物[其中R 1和R 2代表低级烷基，低级环烷基等，或 R 1和R 2一起形成与它们结合的氮原子的脂族含氮杂环; R 3，R 4，R 5，R 6和R 7，R 3， 氢，低级烷基等; R 8代表低级烷基，低级烷氧基等; 并且n表示0-4的整数]。 该化合物作为黑色素浓缩激素受体拮抗剂，可用作中枢神经系统疾病，心血管疾病和代谢紊乱的药物。

    DIARYLMETHYLAMIDE DERIVATIVE HAVING MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISM
    9.
    发明申请
    DIARYLMETHYLAMIDE DERIVATIVE HAVING MELANIN-CONCENTRATING HORMONE RECEPTOR ANTAGONISM 审中-公开
    具有富马酸浓度的HORMONE受体拮抗剂的二甲基甲酰胺衍生物

    公开(公告)号：US20110015198A1

    公开(公告)日：2011-01-20

    申请号：US12919036

    申请日：2009-03-26

    申请人： Kaori Kamijo ,  Minoru Moriya ,  Takao Suzuki ,  Akihiro Takezawa

    发明人： Kaori Kamijo ,  Minoru Moriya ,  Takao Suzuki ,  Akihiro Takezawa

    IPC分类号： A61K31/438 ,  C07D491/107 ,  C07D401/14 ,  C07D487/04 ,  C07D471/04 ,  A61K31/4545 ,  A61K31/437 ,  A61K31/5025 ,  A61P3/04 ,  A61P3/10 ,  A61P1/16 ,  A61P25/24 ,  A61P25/22

    CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D471/04 ,  C07D487/04 ,  C07D491/20

    摘要： [Problem] To provide a melanin-concentrating hormone receptor antagonist useful as a pharmaceutical agent for central diseases, circulatory diseases, and metabolic diseases.[Means for Resolution] Provided is a diarylmethylamide derivative represented by formula (I): Wherein R1a, R1b, R2a, R2b, R3a, and R3b independently represent a hydrogen atom or the like, R4 represents a hydrogen atom, C1-6 alkyl, or the like, R5 represents a hydrogen atom or the like, Z represents C1-6 alkyl or the like, or R4 and Z together form a 4- to 6-membered nitrogen-containing hetero ring, Y1 represents H or the like, Y2 represents H, or Y1 and Y2 together form —O—CH2—, W represents C, SO, or the like, Ar1 represents 6-membered aryl or the like, Ar2 represents 6-membered aryl or the like, and ring A represents a benzene ring, a pyridine ring, or the like.

    摘要翻译： [问题]提供可用作中枢疾病，循环系统疾病和代谢疾病的药剂的黑色素浓缩激素受体拮抗剂。 [解决方法]提供由式（I）表示的二芳基甲基酰胺衍生物：其中R1a，R1b，R2a，R2b，R3a和R3b独立地表示氢原子等，R4表示氢原子，C1-6烷基， 等等，R 5表示氢原子等，Z表示C 1-6烷基等，或者R 4和Z一起形成4至6元含氮杂环，Y1表示H等，Y2表示H等 表示H或Y1和Y2一起形成-O-CH 2 - ，W表示C，SO等，Ar 1表示6元芳基等，Ar 2表示6元芳基等，环A表示 苯环，吡啶环等。