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公开(公告)号:US5789439A
公开(公告)日:1998-08-04
申请号:US861262
申请日:1997-05-21
申请人: Makoto Hosono , Akira Fujita , Giichi Izumi , Tochiro Tatee , Takashi Takahira , Yasuhiko Furuta , Michiko Sakai , Osamu Ishizuka , Takashi Terada , Junpei Itoh
发明人: Makoto Hosono , Akira Fujita , Giichi Izumi , Tochiro Tatee , Takashi Takahira , Yasuhiko Furuta , Michiko Sakai , Osamu Ishizuka , Takashi Terada , Junpei Itoh
IPC分类号: A61K31/35 , A61K31/352
CPC分类号: A61K31/352 , A61K31/35
摘要: The present invention relates to novel pharmaceutical use of forskolin derivatives represented by the general formula: ##STR1## wherein R.sup.1, R.sup.2 and Ac are as defined later ##STR2## (wherein R.sup.3 and R.sup.4 are each hydrogen or lower alkyl group, or R.sup.3 and R.sup.4 may be combined to represent lower alkylene group which may have oxygen or nitrogen atom in the linking chain, and n is an integer of 1 to 5); R.sup.2 represents hydrocarbon group having 2 to 3 carbon atoms; and Ac represents acetyl group. The above-mentioned forskolin derivative or a physiologically acceptable salt thereof can be used as a platelet aggregation inhibiting or controlling agent, spasmolytic agent, therapeutic agent for skin ulcer, peripheral circulation improving agent for limbs and differentiation inducing and promoting agent.
摘要翻译: 本发明涉及由以下通式表示的毛喉素衍生物的新型药物用途:其中R1,R2和Ac如下文定义(其中R3和R4各自为氢或低级烷基,或R3和R4 可以结合表示在连接链中可以具有氧或氮原子的低级亚烷基,n是1〜5的整数); R2表示碳原子数2〜3的烃基, Ac表示乙酰基。 上述的毛喉素衍生物或其生理上可接受的盐可以用作血小板聚集抑制剂,解痉药,皮肤溃疡治疗剂,肢体周边循环改善剂和分化诱导促进剂。
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公开(公告)号:US5057535A
公开(公告)日:1991-10-15
申请号:US101134
申请日:1987-09-25
申请人: Akira Shiozawa , Michio Ishikawa , Giichi Izumi , Katsuhiko Sakitama , Kazuhisa Narita , Shuji Kurashige , Takeji Sakasai , Kazuo Ohtsuki , Hideo Sugimura , Hirotaka Yamamoto
发明人: Akira Shiozawa , Michio Ishikawa , Giichi Izumi , Katsuhiko Sakitama , Kazuhisa Narita , Shuji Kurashige , Takeji Sakasai , Kazuo Ohtsuki , Hideo Sugimura , Hirotaka Yamamoto
IPC分类号: C07C225/06 , C07D295/108
CPC分类号: C07D295/108 , C07C225/06 , C07C2101/14 , C07C2102/10
摘要: A new class of aminoketone derivatives according to the formula: ##STR1## and certain propiophenone derivatives in particular, corresponding to the formula: ##STR2## having central muscle relaxant activity.
摘要翻译: 一类新的具有下式的氨基酮衍生物:特别是某些苯丙酮衍生物,特别是对应于具有中枢肌肉松弛剂活性的式:
。
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