公开(公告)号：US20110171701A1

公开(公告)日：2011-07-14

申请号：US13119499

申请日：2009-10-01

申请人： Makoto Kano ,  Kiyonobu Niwa ,  Kozo Murao

发明人： Makoto Kano ,  Kiyonobu Niwa ,  Kozo Murao

IPC分类号： C12P13/02

CPC分类号： C12P13/02 ,  C12M41/24

摘要： [Problem] The present invention provides a method for producing acrylamide from acrylonitrile using a biocatalyst with high productivity at low cost, in which reaction heat can be efficiently removed even at an industrial reaction scale.[Means for Solving] The present invention relates to a method for producing acrylamide by reacting acrylonitrile in the presence of a biocatalyst, wherein the reaction is performed using a reactor having a reaction volume of 1 m3 or more equipped with a tubular heat exchanger, and wherein the difference between a temperature of a cooling water to be introduced into the heat exchanger and a reaction temperature is maintained from 5 to 20° C.

摘要翻译： 本发明提供了一种使用生物催化剂从丙烯腈制造丙烯酰胺的方法，该生物催化剂以低成本生产率高，即使在工业反应规模下也可有效除去反应热。 [解决方法]本发明涉及在生物催化剂存在下使丙烯腈反应制备丙烯酰胺的方法，其中使用装有管式热交换器的反应容积为1m 3或更大的反应器进行反应，以及 其中导入热交换器的冷却水的温度和反应温度之间的差保持在5至20℃。

公开(公告)号：US5068442A

公开(公告)日：1991-11-26

申请号：US353446

申请日：1989-05-17

申请人： Yoshiro Ashina ,  Takeyuki Fujita ,  Kiyonobu Niwa ,  Takeshi Inagaki ,  Yuko Nikaido

发明人： Yoshiro Ashina ,  Takeyuki Fujita ,  Kiyonobu Niwa ,  Takeshi Inagaki ,  Yuko Nikaido

IPC分类号： B01J29/06 ,  B01J29/08 ,  B01J29/18 ,  B01J29/50 ,  C07B61/00 ,  C07C67/00 ,  C07C209/00 ,  C07C209/16 ,  C07C211/04

CPC分类号： C07C209/16 ,  Y02P20/582

摘要： There is provided a method for maintaining the activity of a zeolite catalyst in the catalytic production of methylamines from methanol and ammonia using a zeolite catalyst as at least one of catalysts applied, which comprises controlling the amount of aldehyde compounds as impurities flowing into a zeolite catalyst layer to about 0.15 g/hr.kg-cat. or lower, as calculated in terms of formaldehyde.

公开(公告)号：US20140134683A1

公开(公告)日：2014-05-15

申请号：US14122052

申请日：2012-05-29

申请人： Makoto Kanou ,  Kiyonobu Niwa

发明人： Makoto Kanou ,  Kiyonobu Niwa

IPC分类号： C12P13/02

CPC分类号： C12P13/02 ,  C07C231/06 ,  C07C233/09

摘要： The present invention relates to a method for producing acrylamide comprising: supplying a raw material water to a reactor, supplying acrylonitrile to the reactor, and hydrating acrylonitrile using a biocatalyst, wherein a temperature of the raw material water in the supplying step of the raw material water to the reactor is equal to or more than freezing point of the raw material water and lower than the reaction temperature by 5° C. or more. The present invention can be provided to the method of producing acrylamide which can be removed the reaction heat produced at the hydration reaction of acrylonitrile effectively with a low cost.

摘要翻译： 本发明涉及一种丙烯酰胺的制造方法，其特征在于，将原料水供给反应器，向所述反应器供给丙烯腈，使用生物催化剂使丙烯腈水合，所述原料水的供给工序中的原料水的温度 反应器的水等于或大于原料水的凝固点，低于反应温度5℃以上。 本发明可以提供给制造丙烯酰胺的方法，其可以以低成本有效地除去丙烯腈的水合反应产生的反应热。

公开(公告)号：US08889907B2

公开(公告)日：2014-11-18

申请号：US12922376

申请日：2009-03-13

申请人： Makoto Kanou ,  Kiyonobu Niwa ,  Masahito Oda

发明人： Makoto Kanou ,  Kiyonobu Niwa ,  Masahito Oda

IPC分类号： C07C231/06 ,  C12P13/02

CPC分类号： C12P13/02

摘要： The present invention provides a method for producing an amide compound from a nitrile compound using a biocatalyst that realizes low cost, energy saving and low environmental burdens. The production method of the amide compound of the present invention is a method for producing an amide compound from a nitrile compound using a biocatalyst in a reactor, wherein the nitrile compound is reacted with the biocatalyst to produce the amide compound under such stirring conditions that the stirring power requirement is in the range of 0.08 to 0.7 kW/m3.

摘要翻译： 本发明提供了使用实现低成本，节能和低环境负担的生物催化剂从腈化合物制造酰胺化合物的方法。 本发明的酰胺化合物的制造方法是使用反应器中的生物催化剂从腈化合物制造酰胺化合物的方法，其中使腈化合物与生物催化剂反应以在搅拌条件下制备酰胺化合物， 搅拌功率要求在0.08〜0.7kW / m3的范围内。

公开(公告)号：US06495716B2

公开(公告)日：2002-12-17

申请号：US10083536

申请日：2002-02-27

申请人： Hiroyasu Banba ,  Shigeho Tanaka ,  Kiyonobu Niwa ,  Takakazu Endo

发明人： Hiroyasu Banba ,  Shigeho Tanaka ,  Kiyonobu Niwa ,  Takakazu Endo

IPC分类号： C07C22900

CPC分类号： C07C229/24 ,  C07C227/42

摘要： Crystals of [S,S]-ethylenediamine-N,N′-disuccinic acid which have a bulk density of 0.45 to 1.2 g/cm3, and a process for obtaining these crystals comprising the steps of adjusting an aqueous solution of an [S,S]-ethylenediamine-N,N′-disuccinic acid metal salt to a temperature of 40 to 80° C. and a pH of 1.9 to 4.5, and cooling the solution to a temperature below 40° C. over a period of 0.2 to 10 hours while supplying a mineral acid so as to maintain the pH at 1.9 to 4.5 to precipitate [S,S]-ethylenediamine-N,N′-disuccinic acid in a high yield.

摘要翻译： 具有堆积密度为0.45〜1.2g / cm 3的[S，S] - 乙二胺-N，N'-二琥珀酸的晶体以及获得这些结晶的方法，包括以下步骤：将[S， S] - 乙二胺-N，N'-二琥珀酸金属盐，温度为40〜80℃，pH为1.9〜4.5，在0.2〜 10小时，同时供给无机酸，以保持pH为1.9〜4.5，以高收率沉淀出[S，S] - 乙二胺-N，N'-二琥珀酸。

公开(公告)号：US06906215B1

公开(公告)日：2005-06-14

申请号：US09959565

申请日：2000-04-28

申请人： Shigeho Tanaka ,  Hiroyasu Banba ,  Kiyonobu Niwa

发明人： Shigeho Tanaka ,  Hiroyasu Banba ,  Kiyonobu Niwa

IPC分类号： C07C227/38 ,  C07C227/42 ,  C07C229/24 ,  C07C229/76 ,  C07F15/02 ,  G03C5/44 ,  G03C7/42 ,  D06L3/00

CPC分类号： C07C229/76 ,  C07C227/38 ,  C07C227/42 ,  C07C229/24 ,  C07F15/025 ,  G03C5/44 ,  G03C7/42

摘要： There is provided a powdery S,S-EDDS iron complex improved in its caking property. An S,S-ethylenediamine-N,N′-disuccinic acid iron complex, which is crystalline and has an average particle diameter of from 10 to 1000 μm and a water content of not more than 7% by weight, a powdery S,S-ethylene-N,N′-disuccinic acid (S,S-EDDS) iron complex having a compressive strength of not more than 1 kg/cm2, the compressive strength being measured according to JIS A 1108 after a lapse of 2 months under conditions of a temperature of 50° C. and a load of 300 g/cm2, and a process for producing the same.

摘要翻译： 提供粉末状S，S-EDDS铁络合物，其结块性能得到改善。 S，S-乙二胺-N，N'-二琥珀酸铁络合物，其结晶，平均粒径为10〜1000μm，水含量为7重量％以下，粉末状S，S 亚乙基-N，N'-二琥珀酸（S，S-EDDS）铁络合物，抗压强度不超过1kg / cm 2，抗压强度根据JIS A 1108 在温度为50℃，负荷为300g / cm 2的条件下经过2个月及其制造方法。

公开(公告)号：US5688854A

公开(公告)日：1997-11-18

申请号：US712886

申请日：1996-09-12

申请人： Takeyuki Fujita ,  Kiyonobu Niwa ,  Kazumoto Ogura ,  Michio Fukatsu

发明人： Takeyuki Fujita ,  Kiyonobu Niwa ,  Kazumoto Ogura ,  Michio Fukatsu

IPC分类号： C07C209/16 ,  C07C211/04

CPC分类号： C07C209/16 ,  Y02P20/582

摘要： Disclosed is an improvement in a process for catalytic production of methylamines from methanol and NH.sub.3, or methanol, a mixture of methylamines and NH.sub.3, or a mixture of methylamines and NH.sub.3, in a gaseous phase, over a bed of a zeolite catalyst, where the improvement is that the catalyst bed is divided into two or more sub-beds, and the difference between the inlet and outlet temperatures of each catalyst sub-bed is kept in the range of approximately 5.degree. C. to approximately 70.degree. C. while the reaction is carried out.

摘要翻译： 公开了在沸石催化剂床上在气相中从甲醇和NH 3或甲醇，甲胺和甲胺，甲胺和NH 3的混合物或甲胺和NH 3的混合物催化制备甲胺的方法的改进，其中 改进之处在于催化剂床分为两个或更多个床层，每个催化剂床层的入口和出口温度之间的差别保持在约5℃至约70℃的范围内，而 进行反应。

公开(公告)号：US09181569B2

公开(公告)日：2015-11-10

申请号：US14122052

申请日：2012-05-29

申请人： Makoto Kanou ,  Kiyonobu Niwa

发明人： Makoto Kanou ,  Kiyonobu Niwa

IPC分类号： C07C231/06 ,  C07C233/09 ,  C12P13/02

CPC分类号： C12P13/02 ,  C07C231/06 ,  C07C233/09

摘要： The present invention relates to a method for producing acrylamide comprising: supplying a raw material water to a reactor, supplying acrylonitrile to the reactor, and hydrating acrylonitrile using a biocatalyst, wherein a temperature of the raw material water in the supplying step of the raw material water to the reactor is equal to or more than freezing point of the raw material water and lower than the reaction temperature by 5° C. or more. The present invention can be provided to the method of producing acrylamide which can be removed the reaction heat produced at the hydration reaction of acrylonitrile effectively with a low cost.

摘要翻译： 本发明涉及一种丙烯酰胺的制造方法，其特征在于，将原料水供给反应器，向所述反应器供给丙烯腈，使用生物催化剂使丙烯腈水合，所述原料水的供给工序中的原料水的温度 反应器的水等于或大于原料水的凝固点，低于反应温度5℃以上。 本发明可以提供给制造丙烯酰胺的方法，其可以以低成本有效地除去丙烯腈的水合反应产生的反应热。

公开(公告)号：US20110021819A1

公开(公告)日：2011-01-27

申请号：US12922376

申请日：2009-03-13

申请人： Makoto Kanou ,  Kiyonobu Niwa ,  Masahito Oda

发明人： Makoto Kanou ,  Kiyonobu Niwa ,  Masahito Oda

IPC分类号： C07C231/06

CPC分类号： C12P13/02

摘要： The present invention provides a method for producing an amide compound from a nitrile compound using a biocatalyst that realizes low cost, energy saving and low environmental burdens. The production method of the amide compound of the present invention is a method for producing an amide compound from a nitrile compound using a biocatalyst in a reactor, wherein the nitrile compound is reacted with the biocatalyst to produce the amide compound under such stirring conditions that the stirring power requirement is in the range of 0.08 to 0.7 kW/m3.

摘要翻译： 本发明提供了使用实现低成本，节能和低环境负担的生物催化剂从腈化合物制造酰胺化合物的方法。 本发明的酰胺化合物的制造方法是使用反应器中的生物催化剂从腈化合物制造酰胺化合物的方法，其中使腈化合物与生物催化剂反应以在搅拌条件下制备酰胺化合物， 搅拌功率要求在0.08〜0.7kW / m3的范围内。

公开(公告)号：US06414189B1

公开(公告)日：2002-07-02

申请号：US09530964

申请日：2000-05-18

申请人： Hiroyasu Banba ,  Shigeho Tanaka ,  Kiyonobu Niwa ,  Takakazu Endo

发明人： Hiroyasu Banba ,  Shigeho Tanaka ,  Kiyonobu Niwa ,  Takakazu Endo

IPC分类号： C07C22900

CPC分类号： C07C229/24 ,  C07C227/42

摘要： Crystals of [S,S]-ethylenediamine-N,N′-disuccinic acid which have a bulk density of 0.45 to 1.2 g/cm3, and a process for obtaining these crystals comprising the steps of adjusting an aqueous solution of an [S,S]-ethylenediamine-N,N′-disuccinic acid metal salt to a temperature of 40 to 80° C. and a pH of 1.9 to 4.5, and cooling the solution to a temperature below 40° C. over a period of 0.2 to 10 hours while supplying a mineral acid so as to maintain the pH at 1.9 to 4.5 to precipitate [S,S]-ethylenediamine-N,N′-disuccinic acid in a high yield.

摘要翻译： 具有堆积密度为0.45〜1.2g / cm 3的[S，S] - 乙二胺-N，N'-二琥珀酸的晶体以及获得这些结晶的方法，包括以下步骤：将[S， S] - 乙二胺-N，N'-二琥珀酸金属盐，温度为40〜80℃，pH为1.9〜4.5，在0.2〜 10小时，同时供给无机酸，以保持pH为1.9〜4.5，以高收率沉淀出[S，S] - 乙二胺-N，N'-二琥珀酸。