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    Modified Single-Stranded Polynucleotide
    2.
    发明申请
    Modified Single-Stranded Polynucleotide 有权
    改良单链多核苷酸

    公开(公告)号：US20130253038A1

    公开(公告)日：2013-09-26

    申请号：US13991209

    申请日：2011-12-01

    申请人： Makoto Koizumi ,  Yasuhide Hirota ,  Makiko Nakayama ,  Mika Ikeda

    发明人： Makoto Koizumi ,  Yasuhide Hirota ,  Makiko Nakayama ,  Mika Ikeda

    IPC分类号： C12N15/113

    CPC分类号： C12N15/113 ,  A61K31/7088 ,  C07C235/08 ,  C07C235/34 ,  C07C235/48 ,  C07C235/56 ,  C12N15/111 ,  C12N2310/3183 ,  C12N2310/531 ,  C12N2320/51

    摘要： It is intended to provide a polynucleotide that is resistant to RNase and has an RNA interference effect, etc. The present invention provides a single-stranded polynucleotide that is derived from a double-stranded polynucleotide comprising a sense strand polynucleotide corresponding to a target gene, and an antisense strand polynucleotide having a nucleotide sequence complementary to the sense strand polynucleotide, and has a structure in which the 5′-end of the antisense strand and the 3′-end of the sense strand are linked via a phenyl group-containing linker to form a phosphodiester structure at each of these ends.

    摘要翻译： 旨在提供对RNase具有抗性并具有RNA干扰作用等的多核苷酸。本发明提供衍生自包含对应于靶基因的有义链多核苷酸的双链多核苷酸的单链多核苷酸， 以及具有与有义链多核苷酸互补的核苷酸序列的反义链多核苷酸，并且具有其中反义链的5'末端和有义链的3'-末端通过含苯基的接头连接的结构 以在这些端部的每一端形成磷酸二酯结构。

    Agents for alleviating symptoms accompanied by inflammation
    3.
    发明授权
    Agents for alleviating symptoms accompanied by inflammation 失效
    用于缓解伴有炎症的症状的药剂

    公开(公告)号：US07323442B2

    公开(公告)日：2008-01-29

    申请号：US10073297

    申请日：2002-02-13

    申请人： Masako Yajima ,  Makiko Nakayama ,  Yumi Tsukamoto ,  Kaoru Koide ,  Tamotsu Kuwata ,  Takaji Yajima

    发明人： Masako Yajima ,  Makiko Nakayama ,  Yumi Tsukamoto ,  Kaoru Koide ,  Tamotsu Kuwata ,  Takaji Yajima

    IPC分类号： A61K38/16 ,  A61K35/14

    CPC分类号： A61K38/40

    摘要： The present invention provides agents for alleviating symptoms resulting from inflammation, which have an activity to alleviate inflammatory symptoms caused by bacterial infection, particularly accumulation of body fluid such as bronchocavemous plasma exudation, ascites, etc., at the inflammatory site, or excessive increase of blood neutrophils; symptoms resulting from inflammation caused by bacterial infection, particularly accumulation of body fluid such as bronchocavemous plasma exudation ascites, etc., at the inflammatory site, or excessive increase of blood neutrophils, can be alleviated effectively by ingesting or administering orally or parenterally a composition containing human-type lactoferrin as an effective component.

    摘要翻译： 本发明提供减轻由炎症引起的症状的药剂，其具有减轻细菌感染引起的炎性症状的活性，特别是在炎性部位积累体液如支气管血浆渗出物，腹水等，或过度增加 血液中性粒细胞; 通过摄取或口服或非肠道给药可以有效地减轻由细菌感染引起的炎症，特别是炎症部位的支气管血浆渗出性腹水等体积积累或嗜中性粒细胞过度增加引起的炎症症状， 人型乳铁蛋白作为有效成分。