公开(公告)号：US09114098B2

公开(公告)日：2015-08-25

申请号：US12996236

申请日：2009-05-27

申请人： Makoto Moriyama ,  Kazuyoshi Kaminaka ,  Junichi Matsuda ,  Chikateru Nozaki

发明人： Makoto Moriyama ,  Kazuyoshi Kaminaka ,  Junichi Matsuda ,  Chikateru Nozaki

IPC分类号： C07K14/18 ,  A61K39/00

CPC分类号： A61K39/00 ,  A61K2039/5252 ,  A61K2039/55588 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/464 ,  Y02A50/466 ,  Y02A50/472 ,  Y02A50/484

摘要： A method for using inactivated Japanese encephalitis virus particles as an adjuvant of a vaccine is provided. A method for using inactivated Japanese encephalitis virus (JEV) particles as an adjuvant of various vaccines or a mixed vaccine, said JEV particles being obtained by inoculating JEV Beijing-1 strain to Vero cells, culturing said JEV-infected cells to give cultured cells or culture supernatant, purifying JEV particles from said cultured cells or culture supernatant and inactivating said JEV particles with formalin, a method for preparing a (mixed) vaccine which comprises a step of letting inactivated Japanese encephalitis virus be contained, and a mixed vaccine prepared by said method.

摘要翻译： 提供了使用灭活的日本脑炎病毒颗粒作为疫苗佐剂的方法。 使用灭活的日本脑炎病毒（JEV）颗粒作为各种疫苗或混合疫苗的佐剂的方法，所述JEV颗粒通过将JEV Beijing-1菌株接种到Vero细胞获得，培养所述JEV感染的细胞以产生培养的细胞或 培养上清液，从所述培养细胞或培养上清液中纯化JEV颗粒，并用福尔马林灭活所述JEV颗粒，制备包含使灭活的日本脑炎病毒的步骤的（混合）疫苗的方法，以及由所述 方法。

公开(公告)号：US20110081376A1

公开(公告)日：2011-04-07

申请号：US12996236

申请日：2009-05-27

申请人： Makoto Moriyama ,  Kazuyoshi Kaminaka ,  Junichi Matsuda ,  Chikateru Nozaki

发明人： Makoto Moriyama ,  Kazuyoshi Kaminaka ,  Junichi Matsuda ,  Chikateru Nozaki

IPC分类号： A61K39/295 ,  A61K39/12 ,  A61P31/12 ,  A61P37/04 ,  A61P31/04

CPC分类号： A61K39/00 ,  A61K2039/5252 ,  A61K2039/55588 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/464 ,  Y02A50/466 ,  Y02A50/472 ,  Y02A50/484

摘要： A method for using inactivated Japanese encephalitis virus particles as an adjuvant of a vaccine is provided. A method for using inactivated Japanese encephalitis virus (JEV) particles as an adjuvant of various vaccines or a mixed vaccine, said JEV particles being obtained by inoculating JEV Beijing-1 strain to Vero cells, culturing said JEV-infected cells to give cultured cells or culture supernatant, purifying JEV particles from said cultured cells or culture supernatant and inactivating said JEV particles with formalin, a method for preparing a (mixed) vaccine which comprises a step of letting inactivated Japanese encephalitis virus be contained, and a mixed vaccine prepared by said method.

摘要翻译： 提供了使用灭活的日本脑炎病毒颗粒作为疫苗佐剂的方法。 使用灭活的日本脑炎病毒（JEV）颗粒作为各种疫苗或混合疫苗的佐剂的方法，所述JEV颗粒通过将JEV Beijing-1菌株接种到Vero细胞获得，培养所述JEV感染的细胞以产生培养的细胞或 培养上清液，从所述培养细胞或培养上清液中纯化JEV颗粒，并用福尔马林灭活所述JEV颗粒，制备包含使灭活的日本脑炎病毒的步骤的（混合）疫苗的方法，以及由所述 方法。

公开(公告)号：US5484560A

公开(公告)日：1996-01-16

申请号：US378769

申请日：1995-01-26

申请人： Makoto Moriyama ,  Kouichi Kuwano ,  Ikuo Tochizawa

发明人： Makoto Moriyama ,  Kouichi Kuwano ,  Ikuo Tochizawa

IPC分类号： C08J7/00 ,  B29C35/04 ,  B29C35/08 ,  B29C59/10 ,  B29C59/16 ,  B29C71/02 ,  C08J7/04 ,  B29C71/04

CPC分类号： B29C59/16 ,  B29C71/02 ,  B29C2035/0827 ,  B29C35/045 ,  B29C59/10

摘要： A method which includes enhancing effects upon treating the surface of a thermoplastic resin article by a surface-activating treatment such as corona discharge and the like or by a primer treatment and, thereby, improving coating performance, printability, adhesiveness and so forth of the thermoplastic resin article. The resin article is subjected to a surface-heating treatment which comprises heating only surface layer of the resin article up to a melting point of the thermoplastic resin or a higher temperature followed by cooling the surface layer, and then, subjected to the surface-activating treatment or primer coating.

摘要翻译： 通过表面活化处理如电晕放电等或通过底漆处理来提高热塑性树脂制品的表面处理效果的方法，从而提高热塑性树脂制品的涂布性能，印刷性，粘合性等。 树脂制品。 对树脂制品进行表面加热处理，其包括仅将树脂制品的表面层加热至热塑性树脂的熔点或较高温度，然后冷却表面层，然后进行表面活化 处理或底漆涂层。

公开(公告)号：US5371649A

公开(公告)日：1994-12-06

申请号：US72988

申请日：1993-06-07

申请人： Akinori Iwata ,  Makoto Moriyama ,  Kouichi Kuwano ,  Kensuke Akutsu ,  Koji Ueki ,  Ikuo Tochizawa ,  Hirohiko Koge ,  Takanori Hara ,  Yuji Tanaka ,  Masatoshi Fujii

发明人： Akinori Iwata ,  Makoto Moriyama ,  Kouichi Kuwano ,  Kensuke Akutsu ,  Koji Ueki ,  Ikuo Tochizawa ,  Hirohiko Koge ,  Takanori Hara ,  Yuji Tanaka ,  Masatoshi Fujii

IPC分类号： B29C59/10 ,  H01T19/04 ,  B29C35/00

CPC分类号： B29C59/103

摘要： In a method of corona discharge processing of resin formings surface, excellent corona discharge processing is possible, even if there is a distance between the resin formings and the discharge electrode, by generating a high voltage pulse having a pulse width of 1 .mu.s or more, an average electric field strength of 4 to 20 kv/cm denoted by applied voltage (wave height) versus interelectrode distance, and a pulse frequency of 10 pps or more. This processing is performed by the apparatus which comprises arranging a transfer conveyor to transfer the resin formings, a counter-electrode placed in a down side of the transfer conveyor, a dielectric to cover a surface of the counter-electrode, and a number of discharge electrodes which are arranged in a definite distance above the resin formings along the transfer route.

摘要翻译： 在树脂制表面的电晕放电处理方法中，即使树脂构成物与放电电极之间存在距离，也可以通过产生脉冲宽度为1μm以上的高电压脉冲进行优良的电晕放电处理 ，由施加电压（波高）与电极间距离表示的平均电场强度为4〜20kv / cm，脉冲频率为10pps以上。 该处理由包括布置传送输送机以传送树脂结构的装置，放置在转印输送机的下侧的对置电极，覆盖对置电极的表面的电介质和多个放电 沿着传送路线布置在树脂结构上方一定距离上的电极。